Anti-microbial photodynamic therapy: useful in the future?

Maisch, Tim

doi:10.1007/s10103-006-0409-7

Cited by 317 publications

(261 citation statements)

References 89 publications

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“…they provide almost instantaneous bacterial response, and there is less chance for the development of bacterial resistance and minimal side effects [1]. It is generally assumed that oxygen and nitrogen-based radicals are the most significant contributors to the sterilizing effects of PACT and TTP [5]. Hence, this review aims to provide an overview of (i) in vitro and in vivo studies of both PACT and TTP therapies to treat oral biofilms, and (ii) additional applications in dentistry, as well as to discuss their mechanisms of action and future directions for the field.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic and Tissue Tolerable Plasma Therapies as Alternatives to Antimicrobials to Control Pathogenic Biofilms

Paschoal

Dantas

Duarte

2015

Curr Oral Health Rep

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The need for novel antimicrobial techniques has become critical for a number of reasons, including the emergence of resistant strains because of excessive prescription and misuse of antibiotics. The mouth is colonized by a large number of microorganisms. When these microorganisms are organized as biofilms they can contribute to chronic diseases in the human population, such as dental caries, candidiasis, and periodontal disease. Hence, alternative antimicrobial approaches have risen to facilitate the treatment of these diseases. As novel therapies, photodynamic antimicrobial chemotherapy and tissue-tolerable plasma are promising methods that offer the possibility of microbial decontamination with decreased odds for the traditional side effects. Thus, the present review aims to offer an overview and future directions of these new approaches to control pathogenic oral biofilms.

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Section: Introductionmentioning

confidence: 99%

Photodynamic and Tissue Tolerable Plasma Therapies as Alternatives to Antimicrobials to Control Pathogenic Biofilms

Paschoal

Dantas

Duarte

2015

Curr Oral Health Rep

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“…Although photodynamic therapy (PDT) is currently being applied in cancer cell elimination (Allison & Sibata, 2010;Ericson et al, 2008), more attention has been paid to its application in antimicrobial treatment (Wood et al, 2006;Donnelly et al, 2007;Maisch, 2007). Due to the growing number of antibiotic-resistant micro-organisms, research is focusing on PDT as an alternative chemotherapy modality (Garcez et al, 2010;Kharkwal et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial photodynamic therapy using visible light plus water-filtered infrared-A (wIRA)

Al‐Ahmad

Tennert

Karygianni

et al. 2013

Journal of Medical Microbiology

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The aim of this study was to investigate the effectiveness of antimicrobial photodynamic therapy (APDT) using visible light together with water-filtered infrared-A (VIS+wIRA) to eradicate single species of planktonic bacteria and micro-organisms during initial oral bacterial colonization in situ. A broadband VIS+wIRA radiator with a water-filtered spectrum in the range 580-1400 nm was used for irradiation. Toluidine blue (TB) was utilized as a photosensitizer at concentrations of 5, 10, 25 and 50 mg ml "1 . The unweighted (absolute) irradiance was 200 mW cm "2 and it was applied for 1 min. Planktonic cultures of Streptococcus mutans and Enterococcus faecalis were treated with APDT. Salivary bacteria harvested by centrifugation of native human saliva were also tested. In addition, initial bacterial colonization of bovine enamel slabs carried in the mouths of six healthy volunteers was treated in the same way. Up to 2 log 10 of S. mutans and E. faecalis were killed by APDT. Salivary bacteria were eliminated to a higher extent of 3.7-5 log 10 . All TB concentrations tested proved to be highly effective. The killing rate of bacteria in the initial oral bacterial colonization was significant (P50.004) at all tested TB concentrations, despite the interindividual variations found among study participants. This study has shown that APDT in combination with TB and VIS+wIRA is a promising method for killing bacteria during initial oral colonization. Taking the healing effects of wIRA on human tissue into consideration, this technique could be helpful in the treatment of peri-implantitis and periodontitis. INTRODUCTIONAlthough photodynamic therapy (PDT) is currently being applied in cancer cell elimination (Allison & Sibata, 2010;Ericson et al., 2008), more attention has been paid to its application in antimicrobial treatment (Wood et al., 2006;Donnelly et al., 2007;Maisch, 2007). Due to the growing number of antibiotic-resistant micro-organisms, research is focusing on PDT as an alternative chemotherapy modality (Garcez et al., 2010;Kharkwal et al., 2011). Since PDT causes damage to different parts of microbial cells and affects different interaction pathways in the micro-organisms, the development of antibiotic resistance against PDT can be excluded (Wainwright et al., 2010).PDT impresses with its excellent target-cell specificity and high efficiency. The photodynamic effect requires a photosensitizer, suitable light and oxygen. The photosensitizer can be transferred to the high-energy triplet state and reacts with oxygen, producing singlet oxygen and other radical species which themselves cause increased target cell damage (Konopka & Goslinski, 2007). The photosensitizer should be non-toxic and show antimicrobial activity only after activation by illumination. In addition it should not be bio-destructible. Light sources used in PDT should produce low-power visible light at a specific wavelength (or range of wavelengths) which itself does not harm human tissues in the absence of the photosensitizer. Additionally, light s...

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“…Assuming groups A and B were homogeneous in age, gender, HSCT protocol, oral care before hospitalization and that low power laser therapy (LPLT) is not bactericide, the relevant difference between the groups was the use of mouthwash with 0,12% chlorhexidine during hospitalization in the GA. It should be highlighted though that LPLT is bactericide when used with photosensitizer (dye) as an anti-microbial photodynamic therapy (20). The excellent results concerning bacteremia α-hemolytic viridans granted to the preparation of the oral cavity before HSCT and the maintenance of oral hygiene with toothbrush during HSCT.…”

Section: Discussionmentioning

confidence: 99%

Streptococcal bacteraemia in patients submitted to hematopoietic stem cell transplantation: The role of tooth brushing and use of chlorhexidine

Antunes

Ferreira²,

Faria³

et al. 2010

Med Oral

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Anti-microbial photodynamic therapy: useful in the future?

Cited by 317 publications

References 89 publications

Photodynamic and Tissue Tolerable Plasma Therapies as Alternatives to Antimicrobials to Control Pathogenic Biofilms

Photodynamic and Tissue Tolerable Plasma Therapies as Alternatives to Antimicrobials to Control Pathogenic Biofilms

Antimicrobial photodynamic therapy using visible light plus water-filtered infrared-A (wIRA)

Streptococcal bacteraemia in patients submitted to hematopoietic stem cell transplantation: The role of tooth brushing and use of chlorhexidine

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