Anti‐Monkeypox Infection Approaches: From Prevention to Therapeutic Lines

Ghafari, Somayeh; Rukerd, Mohammad Rezaei Zadeh; Bashash, Davood; Nakhaie, Mohsen; Charostad, Javad; Zarei, Mohammad; Dehghani, Azam

doi:10.1002/cpdd.1275

Cited by 4 publications

(1 citation statement)

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“…12 MPXV is categorized within the Poxviridae family, specifically under the subfamily Chordopoxvirinae and the genus Orthopoxvirus, which also includes vaccinia virus (VACV), variola virus (VARV) and cowpox virus (CPXV). [13][14][15] Poxviruses are characterized by their brick-shaped appearance, housing a linear dsDNA genome, and they are enveloped by a lipoprotein membrane. Apart from their dependence on host ribosomes for mRNA translation, poxvirus genomes encompass all the necessary proteins essential for replication, transcription, assembly and release of new viral particles.…”

Section: Introductionmentioning

confidence: 99%

From Entry to Evasion: A Comprehensive Analysis of Host-Virus Interactions for Monkeypox

Sofiani,

Rukerd,

Charostad

et al. 2024

Infect Microb Dis

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Monkeypox (Mpox) has posed a novel challenge and emerged as a threat to global public health since the onset of its outbreak in 2022. Mpox is spreading throughout the world in both endemic and non-endemic countries, indicating that its behavior is evolving. The prevalence of Mpox and the risk of a global pandemic necessitate a better understanding of Mpox virus replications and interactions with the host. Here, we attempted to provide a detailed comprehensive review of Mpox virus behavior at the molecular level from the entry level to the establishment of a successful infection, including attachment and entry, DNA replication, protein expression, and viron assembly and egress. This review also describes its strategies to evade host immune responses and inhibit apoptosis, and uncovers underlying molecular mechanisms such as subverted signaling pathways and cellular factors behind host-viral interactions.

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