Anti-Mullerian Hormone (AMH) and adenomyosis: Mini-review of literature of the last 5 years

Gulino, Ferdinando Antonio; Dilisi, Valentina; Capriglione, Stella; Cannone, Francesco; Catania, Francesco; Martire, Francesco Giuseppe; Tuscano, Attilio; Gulisano, Marianna; D’Urso, Valentina; Stefano, A. Di; Cimino, Monia Caterina; Filippini, Maurizio; Latella, S.; Sammarini, Margaret; Musmeci, Giulia; Palumbo, Marco

doi:10.3389/fendo.2022.1014519

Cited by 4 publications

(1 citation statement)

References 25 publications

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“…After adjusting for age, no significant differences were observed between individuals with or without coexisting adenomyosis. The relationship between adenomyosis and AMH concentration remains uncertain ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Risk factors associated with changes in serum anti-Müllerian hormone levels before and after laparoscopic cystectomy for endometrioma

Zhang,

Li,

Dai

et al. 2024

Front. Endocrinol.

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BackgroundThe objective of our study was to investigate the risk factors for a decrease in ovarian reserve in patients with endometriomas after standardized laparoscopic procedures and evaluation to provide corresponding clinical guidance for patients with fertility requirements.MethodsAnti-Müllerian hormone (AMH) levels and other clinical data from 233 patients with endometriomas and 57 patients with non-endometrioma ovarian cysts admitted to the Peking Union Medical College Hospital between January 2018 and September 2023 were prospectively analysed. The pretreatment AMH levels of the study groups were compared to assess the impact of endometrioma on ovarian reserve, and the decrease in AMH after treatment was analysed to determine potential risk factors contributing to this change.ResultsPretreatment AMH levels did not significantly differ between patients with endometriomas and those with non-endometrioma ovarian cysts. Within the endometrioma group, older age, higher body mass index (BMI), and shorter menstrual cycles were found to be associated with decreased AMH levels prior to treatment (p<0.05). Participants presenting with bilateral cysts, advanced surgical staging, or a completely enclosed Douglas pouch demonstrated significantly lower levels of AMH prior to treatment compared to those without these conditions (p<0.05). Furthermore, their AMH levels further declined within one year after undergoing laparoscopic cystectomy (p<0.05). However, there was no difference in AMH levels after surgery between patients who successfully became pregnant and those who did not (p>0.05).ConclusionLaparoscopic removal of endometriomas can adversely affect ovarian reserve, especially during bilateral cysts removal and when patients are diagnosed as having a higher stage of endometriosis, further impacting ovarian function. It should be noted that a decrease in AMH levels may not necessarily indicate an absolute decline in fertility. Therefore, it is crucial to conduct thorough patient evaluations and provide comprehensive patient education to offer appropriate guidance for fertility preservation.

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Section: Discussionmentioning

confidence: 99%

Risk factors associated with changes in serum anti-Müllerian hormone levels before and after laparoscopic cystectomy for endometrioma

Zhang,

Li,

Dai

et al. 2024

Front. Endocrinol.

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Progress in High Intensity Focused Ultrasound Ablation for Fertility Preservation Therapy of Uterine Fibroids and Adenomyosis

Zhang,

Li,

Sun

et al. 2024

Reprod. Sci.

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High intensity focused ultrasound (HIFU) is an effective and safe non-invasive treatment method, widely used in the treatment of uterine fibroids and adenomyosis in the field of gynecology. The side effects in HIFU is low in incidence and mild. HIFU can significantly alleviate the symptoms of patients, reduce lesion volumes, improve quality of life, and has good cost-effectiveness. HIFU can accurately ablate the uterine fibroids and adenomyosis lesions, without destroying normal myometrium and endometrium, and thus HIFU is a promising alternative to myomectomy in uterine fibroids patients with fertility desire. Several studies have shown that in terms of ovarian endocrine function protection, HIFU treatment is superior to uterine artery embolization, and similar to myomectomy. Existing limited researches show that patients with uterine fibroids have a favorable pregnancy rate and live birth rate, as well as a lower natural abortion rate after HIFU treatment. Pregnancy rate after HIFU treatment for uterine fibroids is not lower than myomectomy, and higher than uterine artery embolization. HIFU may have significant advantages in shortening pregnancy interval compared with myomectomy. However, the proportion of cesarean section delivery after HIFU treatment is relatively high, and gestational uterine rupture after HIFU treatment exist in literature. Higher quality clinical data is needed to confirm the pregnancy outcomes and safety after HIFU treatment in future.

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Meclizine improves endometrial repair and reduces simulated menstrual bleeding in mice with induced adenomyosis

Mao,

Liu,

Guo

2024

American Journal of Obstetrics and Gynecology

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Anti-Mullerian Hormone (AMH) and adenomyosis: Mini-review of literature of the last 5 years

Cited by 4 publications

References 25 publications

Risk factors associated with changes in serum anti-Müllerian hormone levels before and after laparoscopic cystectomy for endometrioma

Risk factors associated with changes in serum anti-Müllerian hormone levels before and after laparoscopic cystectomy for endometrioma

Progress in High Intensity Focused Ultrasound Ablation for Fertility Preservation Therapy of Uterine Fibroids and Adenomyosis

Meclizine improves endometrial repair and reduces simulated menstrual bleeding in mice with induced adenomyosis

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