Anti-Müllerian hormone in children: a ten-year prospective longitudinal study (EarlyBird 39)

Jeffery, Alison N.; Streeter, Adam; Hosking, Joanne; Wilkin, Terence J.; Nelson, Scott M.

doi:10.1515/jpem-2014-0517

Cited by 20 publications

(13 citation statements)

References 37 publications

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“…Hagen reported a 30% decrease in serum AMH over 2 years following the onset of puberty (from 24 to 17 pmol/L, P < 0.001) (3.36 to 2.38 ng/mL, P < 0.001) . A similar decline in serum AMH from 20 pmol/L (2.8 ng/mL) to 14 pmol/L (1.96 ng/mL) with advancing Tanner stages B1‐B5 was reported by Hagen in 2015 and corroborated by Cui in 2016 and Jeffery (Figure ). A negative correlation between serum AMH and serum inhibin was reported by Lashen between 9 and 11 years ( r = 0.52; P < 0.003) .…”

Section: Resultsmentioning

confidence: 55%

“…[16][17][18][19][20][21] Six studies reported this data in a longitudinal study design. 16,17,[22][23][24][25] All studies show a consistent pattern of an increase in AMH in childhood, a slight decrease at puberty followed by constant levels throughout adolescence.…”

Section: Studies Reporting Outcome Data Stratified By Agementioning

confidence: 81%

“…Six cross‐sectional studies used cross‐sectional data to report the mean/median serum AMH with the reference ranges (SD/10th‐90th/5‐95th/2.5‐97.5th centile) from birth into adult life . Six studies reported this data in a longitudinal study design . All studies show a consistent pattern of an increase in AMH in childhood, a slight decrease at puberty followed by constant levels throughout adolescence.…”

Section: Resultsmentioning

confidence: 99%

“…Twenty‐five studies reported serum AMH levels between 10 and 18 years Only five studies reported serum inhibin levels, and only three reported AFC in adolescence . Following a transient decrease at puberty as detailed above, a broad consensus across studies show constant levels of serum AMH during adolescence.…”

Section: Resultsmentioning

confidence: 99%

“…Sixteen studies reported serum AMH levels between 1 and 10 years. 11,12,[16][17][18]20,22,24,25,[27][28][29][30][31][32][33] A single study, Lashen 24 reported on serum inhibin levels but no studies reported AFC in childhood.…”

Section: Childhoodmentioning

confidence: 99%

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Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Bhide

Pundir

Homburg

et al. 2019

Acta Obstet Gynecol Scand

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Introduction Certain medical disorders as well as their management may affect gonadal function. Recent advances in the management of these conditions accompanied by the availability and success of methods of fertility preservation has highlighted the need for assessment of ovarian reserve in childhood and adolescence. Serum anti‐Mullerian hormone (AMH) and antral follicle count are well established markers of ovarian reserve and serum inhibin has also been used. However, literature on reference ranges for ovarian reserve markers in this age‐group is relatively scarce. Thus, our aim was to evaluate published data to estimate reference values of ovarian reserve makers in childhood and adolescence. Material and methods We performed a systematic review of the literature reporting ovarian reserve markers in childhood and adolescence. We included only those studies examining markers of ovarian reserve in the normal healthy population between the ages of 0 and 19 years. PROSPERO registration: CRD42018119064. Results Serum AMH emerged as the most common biomarker assessed. Serum AMH was detectable at birth and, after a transient increase in infancy, increased steadily in childhood. Following a slight decrease at puberty, levels were constant throughout adolescence with a peak in adolescence or early adulthood. The mean serum AMH values during infancy, childhood and adolescence were 10.55, 22.32 and 31.84 pmol/L, respectively. The corresponding median values were 9.85, 24.49 and 26.32 pmol/L. It was not possible to construct age‐specific reference intervals because of methodological heterogeneity, variations in the assay used to measure AMH and differing interval width for age used in included studies. Serum inhibin showed an increase from childhood to adolescence, with median serum inhibin values of 53.86 pg/mL in adolescence. Antral follicle count showed a significant positive correlation with serum AMH and a median value of 30.52 in adolescence. Conclusions We summarize the trends and levels of biomarkers of ovarian reserve from birth until young adulthood. Peak levels of serum AMH are reported in adolescence or early adulthood. We have reported median/mean values for serum AMH in different age‐groups based on data pooled from several studies, which may be used as a reference when evaluating ovarian reserve in childhood and adolescence especially when considering fertility preservation.

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Section: Resultsmentioning

confidence: 55%

Section: Studies Reporting Outcome Data Stratified By Agementioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Childhoodmentioning

confidence: 99%

See 3 more Smart Citations

Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Bhide

Pundir

Homburg

et al. 2019

Acta Obstet Gynecol Scand

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Paediatric Anti‐Müllerian Hormone measurement: Male and female reference intervals established using the automated Beckman Coulter Access AMH assay

Jopling

Yates

Burgoyne³

et al. 2018

Endocrino Diabet & Metabol

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Summary Objective Anti‐Müllerian Hormone (AMH) concentration is high at birth in males, demonstrating the presence of functional testicular tissue in the prepubertal period, and acting as a useful marker in the investigation of paediatric reproductive disorders. AMH also provides a tool in the investigation of female virilization, premature ovarian failure and polycystic ovarian syndrome in childhood. Robust, assay‐specific paediatric AMH reference intervals are therefore required for clinical interpretation of results. The aim of this study was to derive age‐specific AMH reference intervals for males and females aged 0‐18 years. Design and Patients Plasma samples were obtained from patients at Royal Manchester Children's Hospital and analysed for AMH using the automated Beckman Coulter Access AMH Assay. Patients under investigation for paediatric reproductive or endocrine disorders were excluded from the study. Measurements Seven hundred and 2 patient plasma samples (465 male, 237 female) were subject to AMH measurement, and results were analysed in order to derive continuous and discrete reference intervals for the paediatric age range. Results Clear discrimination between male and female AMH results was evident in the prepubertal age range, with some overlap between the genders following pubertal onset. Conclusions We have derived age‐related reference intervals for plasma AMH in the paediatric age range (0‐18 years) using the automated Beckman Coulter Access AMH assay which will aid in the investigation of paediatric endocrine disorders such as disorders of sexual development.

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Hormonal Control of Puberty

Loomba-Albrecht

Styne

2019

Encyclopedia of Endocrine Diseases

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Anti-Müllerian hormone in children: a ten-year prospective longitudinal study (EarlyBird 39)

Cited by 20 publications

References 37 publications

Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Biomarkers of ovarian reserve in childhood and adolescence: A systematic review

Paediatric Anti‐Müllerian Hormone measurement: Male and female reference intervals established using the automated Beckman Coulter Access AMH assay

Hormonal Control of Puberty

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