Anti-Müllerian Hormone Is a Marker for Chemotherapy-Induced Testicular Toxicity

Levi, Mattan; Hasky, Noa; Stemmer, Salomon M.; Shalgi, Ruth; Ben‐Aharon, Irit

doi:10.1210/en.2015-1310

Cited by 40 publications

(36 citation statements)

References 30 publications

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“…Methotrexate has been documented to cause testicular toxicity in human and animal studies [4]. It is considered as the most widely used antimetabolite agent in the young age, [9] which raises the concern for alleviating its potential risk on fertility of males in the reproductive age [33,34]. So, this study was designed to elucidate the possible protective effect of ginseng against MTX-induced testicular histopathological changes and apoptosis via measuring testicular caspase-3 levels in rats and whether using ginseng nanoparticles has better protective effect than ginseng.…”

Section: Discussionmentioning

confidence: 99%

Ginseng Nanoparticles Protect Against Methotrexate-Induced Testicular Toxicity in Rats

Kamel¹,

Mohammad²,

Maurice³

et al. 2019

Egyptian Journal of Basic and Clinical Pharmacology

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Testicular toxicity of methotrexate (MTX) is a clinically important adverse effect. Ginseng has been demonstrated to stimulate spermatogenesis, prevent chemotherapy-induced testicular injury and to possess antiapoptotic and antioxidant actions. Owing to its low bioavailability, ginseng was formulated to nanoform in the current study. As there is no available data about the protective effects of ginseng or ginseng nanoparticles against MTX-induced testicular toxicity, this study was initiated. Seventytwo male rats were enrolled. Rats were given either ginseng (5oo mg/kg/day), or ginseng nanoparticles (125 and 250 mg/kg/day) orally for 28 consecutive days. Rats received a single dose of MTX (20 mg/kg) intraperitoneally on day 25. Ginseng and ginseng nanoparticles pre-treatment in rats significantly alleviated the testicular histopathological effects induced by MTX. Also, they significantly restored the impaired spermatogenesis induced by MTX via significantly increasing the Johnsen's tubular biopsy score (JTBS). Ginseng and ginseng nanoparticles treatment prior to MTX administration in rats significantly ameliorated MTXinduced testicular apoptosis by significantly decreasing the percentage of caspase-3-immunostained testicular area. Ginseng and ginseng nanoparticles pretreatment caused nonsignificant increase in serum testosterone levels that were significantly decreased by MTX. The results indicate that ginseng and ginseng nanoparticles protect against MTX-induced testicular toxicity in rats, which is suggested to be through inhibition of MTX-induced testicular apoptosis. The protective effect of ginseng nanoparticles was supposed to be better than ginseng in the given doses.

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Section: Discussionmentioning

confidence: 99%

Ginseng Nanoparticles Protect Against Methotrexate-Induced Testicular Toxicity in Rats

Kamel¹,

Mohammad²,

Maurice³

et al. 2019

Egyptian Journal of Basic and Clinical Pharmacology

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“…An estimated threshold dose of 15 Gy induce ovarian dysfunction between 20 and 30 years [6]. Chemotherapy as capecitabine is not a gonadotoxic chemotherapy and did not add ovarian damage [7,8]. Colorectal surgery provides postoperative pelvic adhesions.…”

Section: Discussionmentioning

confidence: 99%

Fertility Preservation Strategies for Rectal Cancer in Reproductive-Age Women

Khiat¹,

Bottin²,

Saïas-Magnan³

et al. 2019

Future Oncol.

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Despite rectal cancer being unusual before 40, fertility preservation (FP) remains a major concern for these reproductive-age women. Treatment usually involves pelvic radiotherapy, neoadjuvant chemotherapy, and surgery of rectum and mesorectum resection, at high risk of impairing fertility in women with risks of premature ovarian failure and radio-induced uterus damage. To date, there is no consensus on FP strategy for rectal cancer. We shared experiences between oncofertility experts from a French research network Groupe de Recherche et d'Etude en Cryoconservation Ovarienne et Testiculaire about a case of rectal cancer in a young woman. Indications, advantages and disadvantages of different FP strategies were discussed: ovarian transposition, cryopreservation of ovarian cortex and oocyte vitrification. This case was the starting point that led to the development of a French multidisciplinary e-meeting for sharing experiences and for suggesting the best strategy when faced with a complex oncofertility case.

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“…5d and 6d ). The inhibin B levels would be higher in presence of germ cells as they are also considered to be the source and involved in the secretion of inhibin B [ 36 , 37 ]. Correspondingly, significant increase of positive signals of MVH in Response group 2 indicated the proliferation and meiosis of the germ cells after the treatment (Fig.…”

Section: Discussionmentioning

confidence: 99%

Spermatogenesis improved by suppressing the high level of endogenous gonadotropins in idiopathic non-obstructive azoospermia: a case control pilot study

Ding

Hong

et al. 2018

Reprod Biol Endocrinol

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BackgroundElevated plasma gonadotropins were associated with desensitization of Sertoli and Leydig cells in the male testis. Testis spermatogenesis ability would be improved via inhibiting high endogenous gonadotropin in patients with severe oligozoospermia. Whether it would be beneficial for non-obstructive azoospermia (NOA) patients was still unclear.MethodsGoserelin, a gonadotropin releasing hormone agonist (GnRHα) was used to suppress endogenous gonadotropin levels (gonadotropin reset) in the NOA patients, improving the sensitization of the Sertoli and Leydig cells. Then human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG) were injected to stimulate them to ameliorate the ability of testicular spermatogenesis. The main outcome measure was the existence of spermatozoa in the semen or by testicular sperm extraction (TESE). Elevation of inhibin B and/or ameliorative expression pattern of ZO-1 was the secondary objective.ResultsA total of 35 NOA men who failed to retrieve sperm via TESE were enrolled. Among these, 10 patients without treatment were selected as control group and secondary TESE was performed 6 months later. Of the 25 treated men, inhibin B was elevated in 11 patients in the first 4 weeks (Response group), while only 5 patients had constant increase in the following 20 weeks (Response group 2). Of the 5 men, 2 men acquired sperm (Response group 2B), while 3 failed (Response group 2A). Immunofluorescence of mouse vasa homologue (MVH) and ZO-1 showed that both positive MVH signals and ZO-1 expression were significantly increased in the Response group 2, but only Response group 2B showed ameliorative ZO-1 distribution.ConclusionsGonadotropin reset, a new therapeutic protocol with GnRHα, was able to improve the ability of testicular spermatogenesis in the NOA patients through restoring the sensitivity of Sertoli and Leydig cells, which were reflected by elevated inhibin B and ameliorative ZO-1 expression and distribution.Trial registrationClinicalTrials.gov identifier: NCT02544191.Electronic supplementary materialThe online version of this article (10.1186/s12958-018-0401-7) contains supplementary material, which is available to authorized users.

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Anti-Müllerian Hormone Is a Marker for Chemotherapy-Induced Testicular Toxicity

Cited by 40 publications

References 30 publications

Ginseng Nanoparticles Protect Against Methotrexate-Induced Testicular Toxicity in Rats

Ginseng Nanoparticles Protect Against Methotrexate-Induced Testicular Toxicity in Rats

Fertility Preservation Strategies for Rectal Cancer in Reproductive-Age Women

Spermatogenesis improved by suppressing the high level of endogenous gonadotropins in idiopathic non-obstructive azoospermia: a case control pilot study

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