Anti‐mullerian hormone levels decline with the presence of antiphospholipid antibodies

Vega, Mario; Barad, David H.; Yu, Yong; Darmon, Sarah K.; Weghofer, Andrea; Kushnir, Vitaly A.; Gleicher, Norbert

doi:10.1111/aji.12551

Cited by 26 publications

(18 citation statements)

References 29 publications

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“…10 A 2014 study assessed the ovarian reserve of patients with APS and observed that these women had a lower count of antral follicles than those in the control group. Vega et al, in 2016, 29 demonstrated a strong association between aPL positivity and decreasing levels of antimullerian hormone. Thus, antiphospholipid antibodies may represent the 1 st laboratory markers for early ovarian failure associated with autoimmunity.…”

Section: Antiphospholipid Antibody Syndrome and Primary Infertilitymentioning

confidence: 97%

“…It also can decrease ovarian reserve. 29 The term ovarian reserve, traditionally, has been used to describe the reproductive potential of a woman; in other words, the quantity and quality of the oocytes she possesses. However, ovarian reserve markers serve as a substitute for oocyte quantity, but are poor indicators of oocyte quality.…”

Section: Antiphospholipid Antibody Syndrome and Primary Infertilitymentioning

confidence: 99%

“…The confirmation of this association in future studies, therefore, could lead to the early diagnosis of this condition in many women. 29,31 Antiphospholipid antibody syndrome and obstetrics morbidity…”

Section: Antiphospholipid Antibody Syndrome and Primary Infertilitymentioning

confidence: 99%

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Antiphospholipid Antibody Syndrome and Infertility

Rodrigues

Soligo

Pannain

2019

Rev Bras Ginecol Obstet

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Antiphospholipid antibody syndrome (APS) is a systemic, autoimmune, prothrombotic disease characterized by persistent antiphospholipid antibodies (aPLs), thrombosis, recurrent abortion, complications during pregnancy, and occasionally thrombocytopenia. The objective of the present study was to review the pathophysiology of APS and its association with female infertility. A bibliographic review of articles of the past 20 years was performed at the PubMed, Scielo, and Bireme databases. Antiphospholipid antibody syndrome may be associated with primary infertility, interfering with endometrial decidualization and with decreased ovarian reserve. Antiphospholipid antibodies also have direct negative effects on placentation, when they bind to the trophoblast, reducing their capacity for invasion, and proinflammatory effects, such as complement activation and neutrophil recruitment, contributing to placental insufficiency, restricted intrauterine growth, and fetal loss. In relation to thrombosis, APS results in a diffuse thrombotic diathesis, with global and diffuse dysregulation of the homeostatic balance. Knowing the pathophysiology of APS, which is closely linked to female infertility, is essential for new therapeutic approaches, specialized in immunomodulation and inflammatory signaling pathways, to provide important advances in its treatment.

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Section: Antiphospholipid Antibody Syndrome and Primary Infertilitymentioning

confidence: 97%

Section: Antiphospholipid Antibody Syndrome and Primary Infertilitymentioning

confidence: 99%

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Antiphospholipid Antibody Syndrome and Infertility

Rodrigues

Soligo

Pannain

2019

Rev Bras Ginecol Obstet

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“…39,40 The presence of aPL could be associated with a lower ovarian reserve. 41 The ANA, on the other hand, could impact the embryo development as the development of murine embryos is blocked while incubating with ANA. 42 A recent systematic review shows that the presence of ANA could be correlated to poorer IVF outcomes.…”

Section: Prevalence Of Autoantibodies In Endometriosisassociated Inmentioning

confidence: 99%

Endometriosis with infertility: A comprehensive review on the role of immune deregulation and immunomodulation therapy

Kolańska

Alijotas‐Reig

Cohen

et al. 2020

American J Rep Immunol

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Background: Endometriosis is a multifactorial pathology dependent on intrinsic and extrinsic factors, but the immune deregulation seems to play a pivotal role. In endometriosis-associated infertility, this could raise the benefit of immunomodulatory strategies to improve the results of ART. In this review, we will describe (1) sera and peritoneal fluid cytokines and immune markers; (2) autoantibodies; and (3) immunomodulatory treatments in endometriosis with infertility.

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“…For females, the etiologies can be divided by organs into ovulation disorders [polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI), etc. ], tubal (Vega et al, 2016).…”

Section: Serum Autoantibodies and Female Infertilitymentioning

confidence: 99%

Precise Personalized Medicine in Gynecology Cancer and Infertility

Zhang

Yang

2020

Front. Cell Dev. Biol.

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Since the conception of precision medicine has been put forward in oncology, this idea has been popularized and applied in many specialties. Significant progress has been made toward personalizing the entire process, including diagnosis, treatment planning, and embryo identification, and combining large-scale genetic information data and knowledge discovery can offer better prospects in reproductive medicine. This work reviews the application of precision medicine and possibilities in reproductive medicine and gynecologic cancer diagnosis and treatment. The limitations and challenges of precision medicine in this area remain to be discussed.

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Anti‐mullerian hormone levels decline with the presence of antiphospholipid antibodies

Abstract: APAs but no other immune markers appear associated with decreased levels of AMH, supporting the hypothesis that non-specific autoimmunity may adversely affect ovarian reserve.

Cited by 26 publications

References 29 publications

Antiphospholipid Antibody Syndrome and Infertility

Antiphospholipid Antibody Syndrome and Infertility

Endometriosis with infertility: A comprehensive review on the role of immune deregulation and immunomodulation therapy

Precise Personalized Medicine in Gynecology Cancer and Infertility

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