Anti-Müllerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology

Marca, Antonio La; Giulini, Simone; Tirelli, Alessandra; Bertucci, Emma; Marsella, Tiziana; Xella, Susanna; Volpe, Annibale

doi:10.1093/humrep/del421

Cited by 299 publications

(231 citation statements)

References 33 publications

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“…AMH is an established marker of OR, and previous work showed its value in predicting the ovarian response to COS [5,19]. More recently, the accuracy of AMH in predicting live birth was tested by independent groups: some data showed that AMH could be used as a prognostic factor [20][21][22], but its predictive value at low or very low concentrations was not clearly clarified.…”

Section: Discussionmentioning

confidence: 99%

“…Anti-müllerian hormone (AMH) is an established marker of OR and is considered the most reliable predictor of ovarian responsiveness to controlled ovarian stimulation (COS) [4]. A circulating AMH level of 0.7 ng/ml has been claimed to be the threshold value for poor ovarian responsiveness to COS [5,6], whereas levels below 0.1-0.35 ng/ml have been associated with a high risk of cycle cancellation due to extremely poor response [7,8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

IVF results in patients with very low serum AMH are significantly affected by chronological age

Revelli

Biasoni

Gennarelli

et al. 2016

J Assist Reprod Genet

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Purpose The aims of this study were to assess the outcome of in vitro fertilization (IVF) in women with very low circulating anti-müllerian hormone (AMH) and to investigate factors affecting their probability of pregnancy. Methods The outcome of 448 IVF cycles in 361 women with circulating AMH <0.5 ng/ml was retrospectively analyzed. Results Cycle cancellation rate was 14.5 %; patients whose cycle was cancelled had significantly lower AMH than women who reached oocyte pickup (OPU). Among those who reached OPU, age significantly affected the success rate: despite comparable AMH levels, patients below 35 years obtained significantly more oocytes and a better clinical pregnancy rate (CPR)/OPU than patients aged 35-39 or 40-43 (31 % vs. 23.2 % vs. 10.2 %, respectively; p = 0.001). Differently, comparable IVF results were observed stratifying patients for AMH levels in the range 0.14-0.49 ng/ml. Multivariable logistic regression analysis confirmed that the probability of pregnancy was significantly affected by age, but not by small differences in AMH level. Conclusions Women with very low (<0.5 ng/ml) AMH levels undergoing IVF still have reasonable chances of achieving a pregnancy, but their prognosis is significantly affected by chronological age. Very low AMH levels are associated with a relevant risk of cycle cancellation but should not be considered a reason to exclude a couple from IVF.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

IVF results in patients with very low serum AMH are significantly affected by chronological age

Revelli

Biasoni

Gennarelli

et al. 2016

J Assist Reprod Genet

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“…It has been suggested that AMH levels may effectively represent the ovarian follicular pool where recently, several large prospective studies have reported that its measurement may have potential clinical application in the prediction of the quantitative and qualitative ovarian response during assisted reproductive technologies [7,11,14,15,21,23,25]. As a result, AMH is currently being used as a novel clinical marker of ovarian reserve as well as a guide to the response to gonadotropin [8].…”

Section: Introductionmentioning

confidence: 99%

What is the optimal threshold of serum Anti-Müllerian hormone (AMH) necessary for IVM treatments?

Kedem

Yerushalmi

Maman

et al. 2013

J Assist Reprod Genet

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Purpose To assesse circulating levels of Anti-Müllerian hormone (AMH) as a predictor of oocyte number and their potential to mature in vitro in both normo-ovulatory (NO) women and in women with Polycystic Ovary Syndrome (PCOS) undergoing in vitro maturation (IVM) treatments. Methods We prospectively studied NO women and women diagnosed with PCOS, (age range 21-39 years) underwent IVM treatments at our center. Serum AMH levels were quantified before each cycle and correlated to oocytes number, maturation and fertilization during in vitro maturation. Results 104 NO and 30 PCOS IVM cycles were followed with retrieval of a total of 672 and 491 oocytes, respectively. In NO women, the serum AMH level positively correlated with the number of oocytes retrieved, (R=0.6; P <0.0001) the number of M2 oocytes at 24 and 48 h (R=0.4; P <0.01; R=0.26 p<0.007, respectively) and with the total number of M2 oocytes (R=0.47; P<0.0001). In the PCOS group, the serum AMH level positively correlated only with the number of oocytes retrieved (R=0.43; P <0.03). Receiver operating characteristic (ROC) analyses showed that a cutoff AMH level of 1.56 (ng/ml) could identify patients with 5 or more oocytes at OPU with a sensitivity of 83 % and a specificity of 75 %. An AMH level of 1.63 (ng/ml) was the threshold for 5 or more matured oocytes (sensitivity=81 %, specificity=53 %). Conclusions Serum AMH may be used as a marker to identify candidates for IVM treatment in both NO and PCOS women.

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“…This result is in concurrent with that previously reported. 13,20 Ovarian response was diminished with aging, showing poor response (<4 oocytes) at the mean age of 33.4±6.5 23,24 . This inverse relationship between ovarian response and female age was also documented in other studies.…”

Section: Discussionmentioning

confidence: 94%

Impact of Age on Ovarian Response and IVF Outcome during Controlled Ovarian Hyperstimulation in Women from Gaza Strip

et al. 2014

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Anti-Müllerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology

Abstract: For the first time, clinicians may have a reliable serum marker of ovarian response that can be measured independently of the day of the menstrual cycle.

Cited by 299 publications

References 33 publications

IVF results in patients with very low serum AMH are significantly affected by chronological age

IVF results in patients with very low serum AMH are significantly affected by chronological age

What is the optimal threshold of serum Anti-Müllerian hormone (AMH) necessary for IVM treatments?

Impact of Age on Ovarian Response and IVF Outcome during Controlled Ovarian Hyperstimulation in Women from Gaza Strip

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