Anti-Müllerian hormone, testosterone and free androgen index following the dose-adjusted unilateral diathermy in women with polycystic ovary syndrome

Šunj, Martina; Čanić, Tomislav; Jerončić, Ana; Karelović, Dani; Tandara, Marijan; Jurić, Slavica; Palada, Ivan

doi:10.1016/j.ejogrb.2014.05.011

Cited by 14 publications

(40 citation statements)

References 19 publications

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“…of serum AMH was missing as data were presented as median and range (Amer et al 2009, Sunj et al 2014a. The mean ± s.d.…”

Section: Study Selectionmentioning

confidence: 99%

“…The mean ± s.d. was also missing for AFC in two studies (Farzadi et al 2012, Sunj et al 2014a and for FSH in four studies (Weerakiet et al 2007, Sunj et al 2014a, Giampaolino et al 2016, Rezk et al 2016. We obtained the mean ± s.d.…”

Section: Study Selectionmentioning

confidence: 99%

“…of serum AMH and FSH levels from the original data of our previous study (Amer et al 2009). Authors of other studies were contacted and three (Sunj et al 2014a, Giampaolino et al 2016, Rezk et al 2016 responded providing the missing data.…”

Section: Study Selectionmentioning

confidence: 99%

“…Two further studies were excluded, one due to lack of pre-operative serum AMH levels (post-operative AMH levels were compared with a control group) (Weerakiet et al 2007), and the other one (Sunj et al 2014b) due to duplication of another study (Sunj et al 2014a), which is included in the meta-analysis.…”

Section: Excluded Studiesmentioning

confidence: 99%

“…www.reproduction-online.org Farzadi et al 2012, Sunj et al 2014a, Syam et al 2014, Giampaolino et al 2016, Rezk et al 2016. However, given the relatively small numbers of patients included in these studies, further evidence is required to allow a firm conclusion.…”

Section: Introductionmentioning

confidence: 99%

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The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis

Amer¹,

Shamy²,

James³

et al. 2017

Reproduction

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Laparoscopic ovarian drilling (LOD) has been widely used as an effective treatment of anovulatory women with polycystic ovarian syndrome (PCOS). However, there has been a growing concern over a possible damaging effect of this procedure on ovarian reserve. The objective of this study was to investigate the hypothesis that LOD compromises ovarian reserve as measured by post-operative changes in circulating anti-Müllerian hormone (AMH). This meta-analysis included all cohort studies as well as randomised controlled trials (RCTs) investigating serum AMH concentrations and other ovarian reserve markers in women with PCOS undergoing LOD. Various databases were searched including MEDLINE, EMBASE, Dynamed Plus, ScienceDirect, TRIP database, ClinicalTrials.gov and Cochrane Library from January 2000 to December 2016. Sixty studies were identified, of which seven were deemed eligible for this review. AMH data were extracted from each study and entered into the RevMan software to calculate the weighted mean difference (WMD) between pre-and post-operative values. Pooled analysis of all studies (n = 442) revealed a statistically significant decline in serum AMH concentration after LOD (WMD −2.13 ng/mL; 95% confidence interval (CI) −2.97 to −1.30). Subgroup analysis based on duration of follow-up, AMH kit, laterality of surgery and amount of energy applied during LOD consistently showed a statistically significant fall in serum AMH concentration. In conclusion, although LOD seems to markedly reduce circulating AMH, it remains uncertain whether this reflects a real damage to ovarian reserve or normalisation of the high pre-operative serum AMH levels. Further long-term studies on ovarian reserve after LOD are required to address this uncertainty.Reproduction (2017) 154 R13-R21

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“…of serum AMH was missing as data were presented as median and range (Amer et al 2009, Sunj et al 2014a. The mean ± s.d.…”

Section: Study Selectionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Excluded Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis

Amer¹,

Shamy²,

James³

et al. 2017

Reproduction

View full text Add to dashboard Cite

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Laparoscopic ovarian drilling for ovulation induction in women with anovulatory polycystic ovary syndrome

Rakic

Mol

et al. 2020

Cochrane Database of Systematic Reviews

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The impact of repetitive oocyte retrieval on the ovarian reserve: a retrospective cohort study

Marschalek

Ott

Aitzetmueller

et al. 2019

Arch Gynecol Obstet

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Purpose To investigate a possible influence of repetitive micro-traumata on the ovaries in the course of oocyte retrieval during IVF/ICSI treatment on serum anti-Müllerian hormone (AMH) levels. Methods The study included retrospectively collected data from women who underwent three or more consecutive IVF/ICSI treatments between 2007 and 2017. The primary endpoint of the study was to evaluate changes in serum AMH levels on cycle days 1–3 during the course of repetitive IVF/ICSI treatments. Results A total of 125 patients were included in this study. Median AMH levels before the first, second and third IVF/ICSI cycles were 3.8 ng/mL (IQR 1.8–7.1), 3.3 ng/mL (IQR 1.8–6.1) and 3.0 ng/mL (IQR 1.6–5.3), respectively ( p = n.s.). In patients who underwent IVF/ICSI due to polycystic ovary syndrome (PCOS), we found a significant decrease in AMH serum levels between the first [AMH 9.7 ng/mL (IQR 7.4–14.4)] and the third [AMH 5.3 ng/mL (IQR 3.3–10.4)] IVF/ICSI cycles ( p = 0.026). When performing a generalized linear model, we found PCOS to be an independent predictor for serum AMH decrease during the course of three oocyte retrievals ( p < 0.001). Conclusions When comparing the indications for IVF/ICSI, we observed a significant decrease in AMH serum levels after repetitive oocyte retrievals only in women with PCOS, while the decrease in AMH was not significant in patients with tubal factor, endometriosis, male factor and unexplained infertility. This finding leads us to hypothesize that repetitive micro-traumata on the ovarian cortex might diminish/normalize functional ovarian reserve in women with PCOS. Further prospective studies are highly warranted to allow firm conclusions.

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Anti-Müllerian hormone, testosterone and free androgen index following the dose-adjusted unilateral diathermy in women with polycystic ovary syndrome

Cited by 14 publications

References 19 publications

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis

Laparoscopic ovarian drilling for ovulation induction in women with anovulatory polycystic ovary syndrome

The impact of repetitive oocyte retrieval on the ovarian reserve: a retrospective cohort study

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