Anti-muscarinic drugs as preventive treatment of exercise-induced bronchoconstriction (EIB) in children and adults

Bonini, Matteo; Cilluffo, Giovanna; Grutta, Stefania La; Boccabella, Cristina; Usmani, Omar; Viegi, Giovanni; Palange, Paolo

doi:10.1016/j.rmed.2020.106128

Cited by 8 publications

(7 citation statements)

References 74 publications

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“…Some clinicians may opt to use anticholinergic inhaler therapy,32 and mast cell stabilising agents such as cromoglicate or nedocromil33 34 have also been used in the treatment of EIB 12. In patients with EIB and allergies, an antihistamine may also be helpful in improving overall asthma control but does not appear to have an effect on EIB 12 35.…”

Section: Section 3: Clinical Assessment and Management Of Commonly En...mentioning

confidence: 99%

BTS clinical statement for the assessment and management of respiratory problems in athletic individuals

Hull

Burns

Carre

et al. 2022

Thorax

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Section: Section 3: Clinical Assessment and Management Of Commonly En...mentioning

confidence: 99%

BTS clinical statement for the assessment and management of respiratory problems in athletic individuals

Hull

Burns

Carre

et al. 2022

Thorax

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“…The MEF 25–75 % is a potentially sensitive marker of obstruction of peripheral airflow [ 56 ], and it is reduced in early bronchial impairment, which is associated with small airway disease [ 57 ]. The role of small airways in EIB still needs to be clarified and more studies are needed to assess if small airway function and inflammation may be considered reliable predictive markers of EIB in elite athletes [ 58 ]. In our study, there is a strong correlation between hydration status and improvement in MEF 25–75 % among elite cyclists.…”

Section: Discussionmentioning

confidence: 99%

“…VO 2 max is a measure of an individual’s maximum capacity to utilize oxygen during intense exercise. Proper hydration helps regulate body temperature during exercise [ 57 , 58 ]. When the body is dehydrated, it struggles to dissipate heat efficiently, leading to an increase in core body temperature [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Hydration on Pulmonary Function and Development of Exercise-Induced Bronchoconstriction among Professional Male Cyclists

Pigakis,

Stavrou,

Pantazopoulos

et al. 2023

Advances in Respiratory Medicine

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Background: Exercise-induced bronchoconstriction (EIB) is a common problem in elite athletes. Classical pathways in the development of EIB include the osmotic and thermal theory as well as the presence of epithelial injury in the airway, with local water loss being the main trigger of EIB. This study aimed to investigate the effects of systemic hydration on pulmonary function and to establish whether it can reverse dehydration-induced alterations in pulmonary function. Materials and Methods: This follow-up study was performed among professional cyclists, without a history of asthma and/or atopy. Anthropometric characteristics were recorded for all participants, and the training age was determined. In addition, pulmonary function tests and specific markers such as fractional exhaled nitric oxide (FeNO) and immunoglobulin E (IgE) were measured. All the athletes underwent body composition analysis and cardiopulmonary exercise testing (CPET). After CPET, spirometry was followed at the 3rd, 5th, 10th, 15th, and 30th min. This study was divided into two phases: before and after hydration. Cyclists, who experienced a decrease in Forced Expiratory Volume in one second (FEV1) ≥ 10% and/or Maximal Mild-Expiratory Flow Rate (MEF25–75) ≥ 20% after CPET in relation to the results of the spirometry before CPET, repeated the test in 15-20 days, following instructions for hydration. Results: One hundred male cyclists (n = 100) participated in Phase A. After exercise, there was a decrease in all spirometric parameters (p < 0.001). In Phase B, after hydration, in all comparisons, the changes in spirometric values were significantly lower than those in Phase A (p < 0.001). Conclusions: The findings of this study suggest that professional cyclists have non-beneficial effects on respiratory function. Additionally, we found that systemic hydration has a positive effect on spirometry in cyclists. Of particular interest are small airways, which appear to be affected independently or in combination with the decrease in FEV1. Our data suggest that pulmonary function improves systemic after hydration.

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“…Other effective pharmacological therapies for EIB include leukotriene receptor antagonists, 80,81 anticholinergics 82 and mast cell stabilizing agents 83 . Allergen immunotherapy may also be considered as a potential therapeutic option in appropriately selected athletes (i.e., akin to the approach currently adopted in patients with allergic asthma) and should align with recommendations in the general population 84 .…”

Section: Diagnosis and Management Of Respiratory Disordersmentioning

confidence: 99%

Diagnosis and management of allergy and respiratory disorders in sport: An EAACI task force position paper

Price

Walsted

Bonini

et al. 2022

Allergy

Self Cite

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Allergy and respiratory disorders are common in young athletic individuals. In the context of elite sport, it is essential to secure an accurate diagnosis in order to optimize health and performance. It is also important, however, to consider the potential impact or consequences of these disorders, in recreationally active individuals engaging in structured exercise and/or physical activity to maintain health and well-being across the lifespan. This EAACI Task Force was therefore established, to develop an up-to-date, research-informed position paper, detailing the optimal approach to the diagnosis and management of common exercise-related allergic and respiratory con- ditions. The recommendations are informed by a multidisciplinary panel of expertsThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Anti-muscarinic drugs as preventive treatment of exercise-induced bronchoconstriction (EIB) in children and adults

Cited by 8 publications

References 74 publications

BTS clinical statement for the assessment and management of respiratory problems in athletic individuals

BTS clinical statement for the assessment and management of respiratory problems in athletic individuals

Effect of Hydration on Pulmonary Function and Development of Exercise-Induced Bronchoconstriction among Professional Male Cyclists

Diagnosis and management of allergy and respiratory disorders in sport: An EAACI task force position paper

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