Anti‐Myelin Basic Protein Autoantibodies in Rats Stressed by Overcrowdinga

Djordjevic, S.; Bukilica, Mirjana; Dimitrijević, Mirjana; Marković, Biljana; Janković, Branislav D.

doi:10.1111/j.1749-6632.1992.tb49141.x

Cited by 12 publications

(4 citation statements)

References 15 publications

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“…In this study, the stress of overcrowding was associated with increased incidence of positive myelin basic protein autoantibodies in Wister rats (Djordjevic et al, 1992). These positive myelin basic protein autoantibodies occur naturally in low titers in these rats and increase with age (Djordjevic et al, 1992) much like the incidence of positive ANA titers in the human population (Fritzler et al, 1985). In adults with combat related posttraumatic stress disorder (PTSD), decreased Natural Killer cell activity in response to antigenic challenge has been observed (Mosnaim et al, 1993).…”

Section: Discussionmentioning

confidence: 81%

“…These results are similar to a recent preclinical study. In this study, the stress of overcrowding was associated with increased incidence of positive myelin basic protein autoantibodies in Wister rats (Djordjevic et al, 1992). These positive myelin basic protein autoantibodies occur naturally in low titers in these rats and increase with age (Djordjevic et al, 1992) much like the incidence of positive ANA titers in the human population (Fritzler et al, 1985).…”

Section: Discussionmentioning

confidence: 88%

“…The presence of plasma ANA is thought to reflect immune system dysregulation (Fritzler, Pauls, Kinsella, & Bowen, 1985). In preclinical investigations, stress has been associated with an increased incidence of autoimmune antibodies (Djordjevic, Bukilica, Dimitrijevic, Markovic, & Jankovic, 1992). Hence, plasma ANA testing is a simple way to screen for alterations in normal immune homeostatic functions, namely hypofunctioning of the immune cells that actively suppress autoimmunity.…”

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confidence: 99%

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Antinuclear antibodies and thyroid function in sexually abused girls

Bellis

Burke

Trickett

et al. 1996

Journal of Traumatic Stress

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Sexually abused girls manifest dysregulation of physiological stress response systems. In this exploratory investigation, 14 sexually abused and 13 control girls, ages 8-15 years, recruited from a prospective, longitudinal study, underwent plasma antinuclear antibody and thyroid function tests. Thyroid function tests and plasma antinuclear antibody titers did not differ between sexually abused and control girls. However, a significantly higher incidence of plasma antinuclear antibody titers was seen in abused subjects when compared with the frequency of positive antinuclear antibody titers in a sample of 22 adult healthy female volunteers, ages 20-58 years. These findings suggest that sexually abused girls may show evidence of an alteration in normal immune homeostatic function.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 88%

mentioning

confidence: 99%

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Antinuclear antibodies and thyroid function in sexually abused girls

Bellis

Burke

Trickett

et al. 1996

Journal of Traumatic Stress

View full text Add to dashboard Cite

show abstract

“…Several studies of rats have indicated effects of grouping and/or group size on behavioural, physiological and pathological measures of stress (e.g. Boranic et al 1983;Armario et al 1984;Gamallo et al 1988;van Bergeijk et al 1990;Djordjevic et al 1992;Rock et al 1997). However, there is little indication as to the functional, and thus welfare Fraser et al 1997), significance of these effects, or the extent to which they are a function of group size per se or the particular combination of individuals and social responses within groups.…”

mentioning

confidence: 99%