Anti-nemic secondary metabolites produced by Fusarium oxysporum f. sp. ciceris

Kundu, Aditi; Saha, Supradip; Walia, Suresh; Rao, Uma

doi:10.1016/j.aspen.2016.06.003

Cited by 23 publications

(10 citation statements)

References 26 publications

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“…Wang et al (2011) reported anticancer activity against human PC-3 (prostate), PANC-1 (pancreas) and A549 (lung) cells from a secondary metabolite called beauvericin isolated from the endophytic Fusarium oxysporum of the Cinnamomum kanehirae plant. This same endophyte, F. oxysporum, nonpathogenic strains, isolated by Kundu et al (2016), produced , bikaverin (1), (4) and fusarubin (5).…”

Section: Discussionmentioning

confidence: 99%

Secondary metabolites from endophytic fungus from Lippia sidoides Cham.

Ferreira¹,

Santos²,

Soares³

et al. 2017

J. Med. Plants Res.

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Lippia sidoidesCham. (Verbenaceae) is a species native to the Brazilian northeast, widely used in popular medicine. Its leaves were used for the isolation of endophytic fungi and extraction of metabolites. Among them, three were selected according to fungitoxicity tests against the maize phytopathogenic fungus, Curvularia lunata (Wakker). However, the objective of this study was to identify the role of L. sidoides extracts associated with their endophytic fungi, necessary to reduce excess of fungicides applied on the maize crop. Metabolites were evaluated for antioxidant activity by 2.2-diphenyl-1-picrylhydrazyl (DPPH), phenols, total flavonoids and one of it endophytic fungus were evaluated for synergism (Verticilium sp. and plant extracts). The endophytic fungi and plant extracts evaluated for phenolic content ranged from 0.29 ± 0.05 to 96.94 ± 11.86 mgEAG/g, the content of flavonoids from 14.31 ± 1.56 to 192.33 ± 4.58 mgER/g, and antioxidant activity could only be observed for the plant extract with EC 50 81 ± 0.3%. The secondary metabolites identified by HPLC in the plant extract were catechin, quercetin, gallic acid and naringin. Naringenin, catechin, epigallocatechin gallate and quercetin were identified in the extract of the fungi viz. Verticillium sp. and Fusarium sp. Synergistic analysis between a 1:1 proportion of plant and fungal extracts has shown more efficient (79.0%) inhibition of C. lunata. Thus, alternative control of phytopathogenic fungi can be accomplished using plant extracts associated with their endophytic fungi, reducing the excess of fungicides applied on the maize crop.

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Section: Discussionmentioning

confidence: 99%

Secondary metabolites from endophytic fungus from Lippia sidoides Cham.

Ferreira¹,

Santos²,

Soares³

et al. 2017

J. Med. Plants Res.

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“…In fact, endophytic F. oxysporum exhibiting nematocidal activity was found to produce compounds bikaverin (67), 3-O-methyl-8-O-methyl fusarubin (116), 8-O-methyl fusarubin (117), anhydrofusarubin (13), and fusarubin (7), with activity against M. incognita ( Kundu et al 2016). Similarly, chlamydosporin (118) produced by F. chlamydosporum, isolated from the root of Suaeda glauca exhibited significant phytotoxic activity against the radicle growth of Echinochloa crusgalli (Wang et al 2018).…”

Section: Nematicidal Activitymentioning

confidence: 99%

Bioprospecting endophytic fungi from Fusarium genus as sources of bioactive metabolites

Toghueo

2019

Mycology

114

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Endophytic fungi became an attractive source for the discovery of new leads, because of the complexity and the structural diversity of their secondary metabolites. The genus Fusarium comprising about 70 species is extremely variable in terms of genetics, biology, ecology, and consequently, secondary metabolism and have been isolated from countless plants genera from diverse habitats. These endophytic microbes may provide protection and survival strategies in their host plants with production of a repertoire of chemically diverse and structurally unprecedented secondary metabolites reported to exhibit an incredible array of biological activities including antimicrobial, anticancer, antiviral, antioxidants, antiparasitics, immunosuppressants, immunomodulatory, antithrombotic, and biocontrol ability against plants pathogens and nematodes. This review comprehensively highlights over the period 1981-2019, the bioactive potential of metabolites produced by endophytes from Fusarium genus.

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“…Among them, 107 showed the highest potential on both nematodes (LC 50 248.9 µg/mL for M. incognita and LC 50 301.6 µg/mL for R. reniformis), followed by 105 (LC 50 257.6 and 285.3 µg/mL, respectively), compared to carbofuran (LC 50 54.2 and 37.6 µg/mL, respectively). Whilst the methyl-substituted derivatives had moderate activity against M. incognita (LC 50 ranging from 478.5 to 376.4 µg/mL) [88]. Moreover, the EtOAc extracts of F. oxysporum SS46 and SS50 isolated from Smallanthus sonchifolius yielded 105 that showed cytotoxicity against MDA-MB435, HCT-8, and SF295 (IC 50 6.23, 9.85, and 6.32 µg/mL, respectively), compared to doxorubicin (IC 50 0.2, 0.04, and 0.04 µg/mL, respectively) in the MTT assay [84].…”

Section: Quinonesmentioning

confidence: 98%

“…Kundu et al, also purified 119 from F. oxysporum f. sp. ciceris ITCC-3636 EtOAc extract that had a weak anti-nemic potential towards M. incognita (LC 50 392.9 µg/mL) [88]. Additionally, Son et al, reported that 119 isolated from F. oxysporum EF119 showed antimicrobial activities against various phyto-pathogenic oomycetes and fungi.…”

Section: Xanthone Derivativesmentioning

confidence: 99%

Bright Side of Fusarium oxysporum: Secondary Metabolites Bioactivities and Industrial Relevance in Biotechnology and Nanotechnology

Ibrahim

Sirwi

Eid

et al. 2021

JoF

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Fungi have been assured to be one of the wealthiest pools of bio-metabolites with remarkable potential for discovering new drugs. The pathogenic fungi, Fusarium oxysporum affects many valuable trees and crops all over the world, producing wilt. This fungus is a source of different enzymes that have variable industrial and biotechnological applications. Additionally, it is widely employed for the synthesis of different types of metal nanoparticles with various biotechnological, pharmaceutical, industrial, and medicinal applications. Moreover, it possesses a mysterious capacity to produce a wide array of metabolites with a broad spectrum of bioactivities such as alkaloids, jasmonates, anthranilates, cyclic peptides, cyclic depsipeptides, xanthones, quinones, and terpenoids. Therefore, this review will cover the previously reported data on F. oxysporum, especially its metabolites and their bioactivities, as well as industrial relevance in biotechnology and nanotechnology in the period from 1967 to 2021. In this work, 180 metabolites have been listed and 203 references have been cited.

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Anti-nemic secondary metabolites produced by Fusarium oxysporum f. sp. ciceris

Cited by 23 publications

References 26 publications

Secondary metabolites from endophytic fungus from Lippia sidoides Cham.

Secondary metabolites from endophytic fungus from Lippia sidoides Cham.

Bioprospecting endophytic fungi from Fusarium genus as sources of bioactive metabolites

Bright Side of Fusarium oxysporum: Secondary Metabolites Bioactivities and Industrial Relevance in Biotechnology and Nanotechnology

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