Anti-neurodegenerative Activity of Anthocyanin Extract from Endemic Plant Species in the Philippines: A Systematic Review

Lacorte, Laarni Hannah; Asis, Sophia; Buenaventura, Jan Lance Buenaventura to Jan Lance; Bulanhagui, Angelic; Male, Reianna Mae; Maniquis, Kristel Faith; Olandez, Joaquin; Samulde, Keneth Dayle Samulde to Keneth Dayle; Nas, John Sylvester

doi:10.5530/ajbls.2021.10.35

Cited by 3 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the female cohort, the lack of a significant extension in lifespan upon P3G supplementation is a noteworthy finding. Despite the antioxidant properties attributed to anthocyanins, which could potentially confer longevity benefits, the results did not reveal such an effect in female flies (Nas et al, 2021;Nas & Medina, 2023;Nas, 2023). This emphasizes the intricate interactions between bioactive compounds and gender-specific biological systems.…”

Section: Sex-specific Effects Of P3g On Lifespanmentioning

confidence: 85%

“…The number of live fruit flies was recorded every 24 hours for five days of supplementation. The sublethal concentration was determined at which ≥ 90% of the fruit flies were alive after three days (Nas et al, 2021). With this, 50 µg/mL was selected as the high dosage concentration of P3G for the experiment.…”

Section: Sublethal Assaymentioning

confidence: 99%

“…Petunidin-3-glucoside (P3G), an anthocyanin found in various dietary sources, including vegetables, fruits, and wine, exhibits a notable free-radical scavenging capacity attributed to its distinctive ring orientation, which mitigates oxidative stress (Lacorte et al, 2021). While previous research speculates that P3G has the potential to preserve, enhance, and restore motor function by promoting axonal regeneration, there is still no study conducted to prove this .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Petunidin-3-glucoside supplementation causes sex-specific effects on the lifespan and motor function in \(\textit{Drosophila melanogaster}\)

Bernardo,

Delos Santos,

Mabalot

et al. 2024

AJB

View full text Add to dashboard Cite

Petunidin-3-glucoside (P3G), an anthocyanin prevalent in vegetables, fruits, and wine, possesses noteworthy antioxidant properties attributed to its capacity to scavenge free radicals. This property has sparked interest in the potential for anthocyanins to confer benefits on longevity and age-related motor dysfunctions. In this study, the impact of petunidin-3-glucoside (P3G) on the lifespan and motor function in Drosophila melanogaster was examined, both in the presence and absence of neurotoxic substances, such as glyphosate or ethanol. Varying concentrations of P3G were incorporated into the flies' diet immediately after hatching. Subsequently, distinct sets of flies were subjected to diverse conditions, including a stress-free environment, ethanol exposure, and glyphosate exposure. The survival rate of the flies was monitored daily, and their motor function was assessed using a negative geotaxis assay on days 1, 5, 10, and 15 post-eclosion. Only male flies exhibited an extended lifespan under normal and ethanol-exposed conditions. While P3G did not induce significant alterations in overall motor function for male and female flies across various conditions, intriguing variations were observed at different time points. In female flies, low concentrations of P3G seemed to exacerbate motor function decline during mid to late adulthood, particularly in the presence of glyphosate. Conversely, middle P3G concentration improved motor function in male flies during early to mid-adulthood, a trend consistent regardless of neurotoxic exposures. Taken together, the findings underscore the potential sex-specific effects of P3G on both lifespan and motor function, with observed benefits predominantly applicable to male flies. Nonetheless, while suggestive, a more in-depth investigation is imperative to comprehensively determine whether the advantageous impact of P3G on motor function is exclusive to the early to mid-adult stage. As such, this study presents a foundation that warrants further investigation.

show abstract

Section: Sex-specific Effects Of P3g On Lifespanmentioning

confidence: 85%

Section: Sublethal Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Petunidin-3-glucoside supplementation causes sex-specific effects on the lifespan and motor function in \(\textit{Drosophila melanogaster}\)

Bernardo,

Delos Santos,

Mabalot

et al. 2024

AJB

View full text Add to dashboard Cite

show abstract

Cyanidin-3-glucoside Enhances Longevity and Heat Stress Resilience in Drosophila melanogaster

Doringo,

Gapayao,

Medina

et al. 2023

Biomedical and Biotechnology Research Journal (BBRJ)

View full text Add to dashboard Cite

Background: Anthocyanins have gained significant attention in recent years due to their diverse physiological benefits, which include antioxidant and anti-inflammatory properties. However, research on the impact of pure anthocyanin compounds on lifespan under different stress conditions, remains a relatively unexplored area. This study aimed to investigate the influence of cyanidin-3-glucoside (C3G), a pure anthocyanin compound found in common plants, on the lifespan of Drosophila melanogaster (fruit flies) subjected to stress (i.e. energy deprivation and heat stress) and nonstress conditions. Methods: Flies were exposed to various concentrations of C3G from the time of hatching until natural death for the lifespan assay. For stress assays, a separate cohort of male and female flies was subjected to daily heat stress or food deprivation, and their survival was monitored. Results: We found out that C3G prolonged the lifespan of fruit flies in the presence or absence of heat stress. Interestingly, under energy-deprived conditions, lifespan extension was not evident, and a high dose of C3G even led to a shorter lifespan. Moreover, we observed that the sex of the flies did not significantly influence the lifespan modulation by C3G, regardless of whether they were subjected to stress or nonstress conditions. Conclusion: Overall, these findings suggest that C3G may offer promising benefits in enhancing lifespan under certain conditions, while caution should be exercised in dosage selection, especially in energy-deprived scenarios. Further investigations are required to elucidate the underlying mechanisms responsible for the multifaceted effects of C3G on lifespan, thereby exploring its potential applications in promoting longevity and mitigating stress-related challenges.

show abstract

Identification of Anthocyanin Protein Targets in Neisseria gonorrhoeae through Virtual Molecular Docking and Protein Network Analysis

Nas

2024

Journal of Preventive, Diagnostic and Treatment Strategies in Medicine

View full text Add to dashboard Cite

BACKGROUND: Anthocyanins are naturally occurring compounds recognized for their antioxidant properties and potential therapeutic effects. While previous studies have documented their antibacterial activity, their impact on Neisseria gonorrhoeae has not been explored. This study aims to identify the primary protein targets of anthocyanins in N. gonorrhoeae and assess the implications of these interactions within the broader protein network. MATERIALS AND METHODS: We employed molecular docking studies to evaluate the binding affinities of various anthocyanins to key N. gonorrhoeae proteins involved in metabolism, protein degradation, and DNA/RNA modification. In addition, we analyzed protein-protein interactions and gene co-occurrence patterns to elucidate the functional significance of the identified protein targets. RESULTS: Our findings indicate that anthocyanins exhibit high binding affinities for bamE, a protein crucial for maintaining structural integrity and facilitating protein assembly. Network analysis further demonstrates bamE’s integration into a complex protein network, revealing conserved functional relationships across bacterial species. Notably, while direct co-expression of bamE with other proteins was not observed in N. gonorrhoeae, similar patterns in related bacteria suggest conserved regulatory mechanisms. CONCLUSION: The results of this study underscore the potential of anthocyanins to modulate bacterial protein interactions, particularly with bamE, thereby opening avenues for therapeutic interventions against bacterial infections. Further research is essential to fully elucidate these interactions and their implications for bacterial physiology and treatment strategies.

show abstract

Anti-neurodegenerative Activity of Anthocyanin Extract from Endemic Plant Species in the Philippines: A Systematic Review

Cited by 3 publications

References 0 publications

Petunidin-3-glucoside supplementation causes sex-specific effects on the lifespan and motor function in \(\textit{Drosophila melanogaster}\)

Petunidin-3-glucoside supplementation causes sex-specific effects on the lifespan and motor function in \(\textit{Drosophila melanogaster}\)

Cyanidin-3-glucoside Enhances Longevity and Heat Stress Resilience in Drosophila melanogaster

Identification of Anthocyanin Protein Targets in Neisseria gonorrhoeae through Virtual Molecular Docking and Protein Network Analysis

Contact Info

Product

Resources

About