Anti-Neutrophil Cytoplasmic Antibodies In Systemic Lupus Erythematosus And Lupus Nephritis: An Overlapping Syndrome

Jesmin, Tahmina; Roy, Ranjit Ranjan; Anjum, Md. Firoz; Akter, Muslima

doi:10.9790/0853-1603050608

Cited by 2 publications

(1 citation statement)

References 12 publications

(9 reference statements)

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“…The prevalence of ANCAs is reported to be as high as 31% in lupus patients but its role in SLE has no demonstrable clinical significance [3]. SLE/AAV overlap syndrome is a recently described entity where subjects had SLE and microscopic polyangiitis with rapidly developing glomerulonephritis [4, 5]. Majority of the patients were diagnosed concomitantly with SLE and AAV [5].…”

Section: Introductionmentioning

confidence: 99%

Systemic Lupus Erythematosus (SLE) and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis (AAV) Overlap Syndrome: Case Report and Review of the Literature

Itikyala

Pattanaik

Raza

2019

Case Reports in Rheumatology

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We report here the first case of systemic lupus erythematosus (SLE) and antineutrophil cytoplasmic antibody-associated vasculitis overlap syndrome (SLE/AAV) who had granulomatous polyangiitis (GPA) as the initial presentation. SLE/AAV overlap syndrome is an uncommon entity recently described in the literature. Prior reported patients with SLE/AAV overlap syndrome presented with SLE and microscopic polyangiitis (MPA). Our patient initially presented with granulomatous gastric ulcer and later developed respiratory failure. She was diagnosed with GPA. While on maintenance treatment with azathioprine 150 mg/day, she developed hematuria and proteinuria which turned out to be from class V lupus nephritis instead of relapse of vasculitis. Currently, the patient is doing well after treatment with rituximab. Although rare, this entity should be recognized and need to be treated appropriately.

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Section: Introductionmentioning

confidence: 99%

Systemic Lupus Erythematosus (SLE) and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis (AAV) Overlap Syndrome: Case Report and Review of the Literature

Itikyala

Pattanaik

Raza

2019

Case Reports in Rheumatology

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Overlap syndrome SLE - ANCA associated vasculitis

Skácelová¹,

Horák²,

Janková³

2021

Vnitř Lék

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III. interní klinika -nefrologická, revmatologická a endokrinologická, FN a LF UP Olomouc 2 Ústav klinické a molekulární patologie, LF UP Olomouc Výskyt ANCA protilátek bývá u pacientů se systémovým lupus erytematodes (SLE) popisován asi ve 24-31 % případů, nemají však vztah k distribuci a tíži orgánového postižení u SLE a jejich rutinní monitoring se nedoporučuje. Overlap syndrom systémového lupus erytematodes s ANCA asociovanou vaskulitidou (AAV) bývá popisován zcela vzácně, následující kazuistika pacientky SLE s těžkým postižením ledvin v rámci AAV poukazuje na obtížnou diagnostiku a léčbu tohoto syndromu.Klíčová slova: ANCA asociovaná vaskulitida, overlap syndrom, systémový lupus erytematodes. Overlap syndrome SLE -ANCA associated vasculitisIncidence of ANCA antibodies in patients with systemic lupus erythematosus (SLE) is described in 24-31 %, but they are not related to the distribution and severity of organ involvement in SLE; the routine monitoring is not recommended. Overlap syndrome of systemic lupus erythematosus and ANCA associated vasculitis (AAV) is rare. The difficult diagnosis and treatment of this syndrome is described in this case report of the patient with SLE and severe kidney involvement resulting from AAV.

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Anti-Neutrophil Cytoplasmic Antibodies In Systemic Lupus Erythematosus And Lupus Nephritis: An Overlapping Syndrome

Cited by 2 publications

References 12 publications

Systemic Lupus Erythematosus (SLE) and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis (AAV) Overlap Syndrome: Case Report and Review of the Literature

Systemic Lupus Erythematosus (SLE) and Antineutrophil Cytoplasmic Antibody-Associated Vasculitis (AAV) Overlap Syndrome: Case Report and Review of the Literature

Overlap syndrome SLE - ANCA associated vasculitis

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