Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum

Lee, Chia-Lin; Hwang, Tsong‐Long; He, Wan Jung; Tsai, Yi‐Hong; Yen, Chiao Ting; Yen, Hsin Fu; Chen, Chao‐Jung; Wei, Chang; Wu, Yang Chang

doi:10.1016/j.phytochem.2013.06.015

Cited by 26 publications

(19 citation statements)

References 21 publications

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“…Seperately, 85 and 86 presented inflammation inhibitory effects on SAG (IC 50 = 0.62 ± 0.03 and 2.84 ± 0.18 μg/mL, resp.). Compound 85 also inhibited elastase release with IC 50 values of 111.05 ± 7.37 μg/mL [392], while 89 showed anti-neutrophilic inflammatory activity against SAG with an IC 50 value of 3.59 μM [331]. …”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

“…Torvosides J-L ( 95 – 97 ), isolated from the leaves of S. torvum , exhibited substantial anticonvulsant activity in zebrafish seizure assays [323], while 96 also showed considerable antifungal activity against Aspergillus flavus and Fusarium verticillioides with MIC ranging from 31.25 to 250 μg/mL [318]. Compounds 99 and 100 inhibited both inflammatory mediators SAG (IC 50 = 3.49 and 2.87 μM) and elastase release (IC 50 = 2.69 and 0.66 μM) [331], while 123 – 125 convinced cytotoxicities against melanoma A375 [317]. …”

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

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The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

111

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Over the past 30 years, the genus Solanum has received considerable attention in chemical and biological studies. Solanum is the largest genus in the family Solanaceae, comprising of about 2000 species distributed in the subtropical and tropical regions of Africa, Australia, and parts of Asia, e.g., China, India and Japan. Many of them are economically significant species. Previous phytochemical investigations on Solanum species led to the identification of steroidal saponins, steroidal alkaloids, terpenes, flavonoids, lignans, sterols, phenolic comopunds, coumarins, amongst other compounds. Many species belonging to this genus present huge range of pharmacological activities such as cytotoxicity to different tumors as breast cancer (4T1 and EMT), colorectal cancer (HCT116, HT29, and SW480), and prostate cancer (DU145) cell lines. The biological activities have been attributed to a number of steroidal saponins, steroidal alkaloids and phenols. This review features 65 phytochemically studied species of Solanum between 1990 and 2018, fetched from SciFinder, Pubmed, ScienceDirect, Wikipedia and Baidu, using “Solanum” and the species’ names as search terms (“all fields”).

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Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

Section: Chemical Constituents and Their Biological Propertiesmentioning

confidence: 99%

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Kaunda

Zhang

2019

Nat. Prod. Bioprospect.

111

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“…was widely used as a vegetable and food ingredient. It has a wide spectrum of pharmacological activities, such as antimicrobial and antifungal (Balachandran et al 2012), anti-inflammatory (Lee et al 2013), antioxidant (Ramamurthy et al 2012), antihelmintic (Kamaraj et al 2011), antidiabetic (Gandhi et al 2011a;Gandhi et al 2011b) and nephroprotective activities (Mohan et al 2010).…”

Section: Parts Of Plants Utilized For Medicinalmentioning

confidence: 99%

Diversity and distribution of medicinal plants in the Universitas Sumatera Utara Arboretum of Deli Serdang, North Sumatra, Indonesia

et al. 2019

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Abstract. Rahmawaty, Samosir JB, Batubara R, Rauf A. 2019. Diversity and distribution of medicinal plants in the Universitas Sumatera Utara Arboretum of Deli Serdang, North Sumatra, Indonesia. Biodiversitas 20: 1457-1465. The plants found in Universitas Sumatera Utara (USU) Arboretum has the potential to be utilized by the local community to meet their food and medicinal needs. The objectives of this study were to calculate the species diversity, to find out the various parts of plants utilized for medicinal purposes and to map the distribution of medicinal plants in the arboretum. Survey and interview methods were used to collect data. The species diversity was determined using Shannon-Wiener index. Geographic Information System (GIS) was used to map the distribution of medicinal plants. The results showed that there were 17 species of medicinal herbs, 21 species of trees and 12 species of poles in the arboretum. The diversity was classified as moderate based on the calculated value. The most predominant part of plants utilized for medicinal purposes were leaves. The distribution of medicinal plants was mostly clustered and uneven. The condition indicates still there is scope for additional planting of medicinal species to increase the diversity of species, especially in the western and the northern part of the arboretum.

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“…General: Compounds 1−15 and 16−25 were isolated from S. macaonens and S. torvum, respectively [1,2].…”

Section: Methodsmentioning

confidence: 99%

“…In addition, among 16−25 from S. torvum, 18 and 19 could lead to 26.0% and 60.3% healing at 20 g/mL, respectively(Figure 3). Compounds 1−6 and 18−19 which showed antineutrophilic inflammatory effects[1,2], were not able to inhibit immediately allergic degranulation in rat basophilic leukemia RBL-2H3 cells (data not shown), but 2, 4, 5, 6, and 18 could be significantly…”

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confidence: 95%

Saponins from Solanum torvum and S. macaonense with Their Cytotoxic and Anti-allergic Effects

Lee

Yang

Peng

et al. 2017

Natural Product Communications

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Anti-neutrophilic inflammatory steroidal glycosides from Solanum torvum

Cited by 26 publications

References 21 publications

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review

Diversity and distribution of medicinal plants in the Universitas Sumatera Utara Arboretum of Deli Serdang, North Sumatra, Indonesia

Saponins from Solanum torvum and S. macaonense with Their Cytotoxic and Anti-allergic Effects

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