2018
DOI: 10.1016/j.ijpam.2018.03.001
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Anti-NMDA receptor encephalitis in a toddler

Abstract: Anti N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder and is considered to be one of the most common causes of encephalitis in children. Despite the fact that around half of all reported cases are of children, the number of studies that report infants and toddlers is very small. Furthermore, reports on children from the Middle East particularly are extremely rare.We report a 21-month-old Jordanian female toddler with NMDAR encephalitis, who initially presented with behavioral change… Show more

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Cited by 9 publications
(7 citation statements)
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“…Later studies reported patients afflicted without tumor involvement 2,3. Although available data suggest the disease is more prevalent in adult women, and in the non-Caucasian population, the condition has been described in both genders, in multiple races, and throughout the lifespan 4,5. However, increasing case reports of anti-NMDAR encephalitis in the psychiatric literature have demonstrated the significant overlap between neurologic and psychiatric pathology associated with autoimmune encephalitis 610.…”
Section: Introductionmentioning
confidence: 99%
“…Later studies reported patients afflicted without tumor involvement 2,3. Although available data suggest the disease is more prevalent in adult women, and in the non-Caucasian population, the condition has been described in both genders, in multiple races, and throughout the lifespan 4,5. However, increasing case reports of anti-NMDAR encephalitis in the psychiatric literature have demonstrated the significant overlap between neurologic and psychiatric pathology associated with autoimmune encephalitis 610.…”
Section: Introductionmentioning
confidence: 99%
“…In another case report, a 21‐month‐old toddler who presented with prolonged fever and behavioral deterioration with features of an autism spectrum disorder was later diagnosed with anti‐NMDAR encephalitis. This patient also had a concurrent urinary tract infection and gastroenteritis 6 . Fever early in the course of anti‐NMDAR encephalitis is usually the result of a prodromal illness, commonly a respiratory illness or gastroenteritis, and precedes the neurological symptoms 3 .…”
Section: Discussionmentioning
confidence: 96%
“…This patient also had a concurrent urinary tract infection and gastroenteritis. 6 Fever early in the course of anti-NMDAR encephalitis is usually the result of a prodromal illness, commonly a respiratory illness or gastroenteritis, and precedes the neurological symptoms. 3 Persisting fever occurring later in the illness is more likely a result of temperature dysregulation from autonomic dysfunction as a feature of the encephalitis.…”
Section: Discussionmentioning
confidence: 99%
“…Definición de encefalitis por anticuerpos contra el receptor de nmda La encefalitis por anticuerpos contra el receptor de N-metil-D-aspartato (nmda) es una condición autoinmune mediada por anticuerpos antineuronales, caracterizada por presentar manifestaciones graves de la esfera mental, predominantemente, como alteraciones de la conducta, del afecto, estados de catatonia y psicosis, además de trastornos del movimiento y convulsiones (7)(8)(9).…”
Section: Revisión De La Literaturaunclassified