Anti-NMDA receptor encephalitis in Japan

Iizuka, Takahiro; Sakai, Fumihiko; Ide, Takashi; Monzen, Tatsuya; Yoshii, Shin; Iigaya, M.; Suzuki, Kazuhiro; Lynch, David R.; Suzuki, Norihiro; Hata, Takashi; Dalmau, Josep

doi:10.1212/01.wnl.0000278388.90370.c3

Cited by 501 publications

(452 citation statements)

References 19 publications

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“…Los síntomas son de instauración aguda o subaguda (9), con fases identificables (10,11). En el 70 % de los pacientes se inicia con una fase prodrómica de síntomas inespecíficos, como náuseas, diarrea, fiebre y cefalea.…”

Section: Discussionunclassified

Autoinmune encephalitis associated to antibodies against the receptor N-methyl-D-aspartate: report of two cases

Sánchez¹,

Sánchez²,

Olivieri³

et al. 2016

biomedica

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La encefalitis asociada a anticuerpos contra receptores N-metil-D-aspartato es un síndrome neurológico que se presenta más comúnmente en mujeres jóvenes y frecuentemente se asocia al teratoma de ovario. Se caracteriza por un cuadro clínico agudo con síntomas generales inespecíficos que evoluciona hacia deterioro neurológico, psicosis y convulsiones; en su etapa más avanzada, se asocia con movimientos anormales y disautonomía. Se reportan dos casos en mujeres de 23 y 12 años. Dada su baja incidencia, se explica el proceso clínico que llevó a su diagnóstico y las opciones de tratamiento empleadas.Palabras clave: encefalitis; receptores de glutamato; N-metilaspartato; autoinmunidad; inmunoterapia; anticuerpos.doi: http://dx.doi.org/10.7705/biomedica.v37i2.2909 Autoimmune encephalitis associated to antibodies against the N-methyl-D-aspartate receptor: Report of two casesAnti-N-methyl-D-aspartate receptor encephalitis is a neurological syndrome that is more common in young women and is often associated with ovarian teratoma. It is characterized by acute general unspecific symptoms that evolve to neurological deterioration, psychosis and seizures. In its more advanced stage it is associated with abnormal movements and dysautonomia. We report two cases in women of 23 and 12 years of age. Given its low incidence, we present the clinical exercise that led to their diagnoses and the treatment options employed.

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Section: Discussionunclassified

Autoinmune encephalitis associated to antibodies against the receptor N-methyl-D-aspartate: report of two cases

Sánchez¹,

Sánchez²,

Olivieri³

et al. 2016

biomedica

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“…This is clear in paraneoplastic cases where a cross-reactive immune response to neural antigens expressed by a tumour leads to neuronal dysfunction. In idiopathic cases it is possible that an occult tumour may have been eliminated by immune surveillance mechanisms that subsequently generate a neurological syndrome or even that a tumour may not be detectable until much later: anti-NMDAR encephalitis may precede by years the detection of an ovarian teratoma ( (Iizuka et al 2008). A preceding infection may also provoke an antibody-mediated autoimmune response as demonstrated in patients with Guillain Barré syndrome (Willison et al 2002).…”

Section: Discussionmentioning

confidence: 99%

The role of humoral autoimmunity in gastrointestinal neuromuscular diseases

Hubball

Martin

Lang

et al. 2009

Progress in Neurobiology

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Dysfunction of the gastrointestinal neuromuscular apparatus (including interstitial cells ofCajal) is presumed to underlie a heterogeneous group of disorders collectively termed gastrointestinal neuromuscular diseases (GINMDs). Humoral (antibody)-mediated autoimmunity directed against ligand-or voltage-gated ion channels or associated proteins involved in neuromuscular transmission is associated with several acquired neuromuscular diseases of the periphery and is now implicated in an increasing number of less well-characterised diseases. Anti-channel antibodies have been reported in small numbers of patients with GINMD, particularly in those with GI dysfunction secondary to an underlying disease such as neoplasia or infection. However, little is known of humoral autoimmunity in primary GINMDs.This thesis investigated the association between anti-channel antibodies and GINMD, and the human GI tract as a potential target of anti-channel antibodies. The presence of antivoltage-and ligand-gated antibodies was investigated in the serum of patients with primary achalasia, enteric dysmotility and intestinal pseudo-obstruction, and in those with GINMD secondary to Chagas' disease. The functional effect of sera from some of these patients on colonic smooth muscle contractility was also characterised. Finally, the distribution of six voltage-gated potassium channels (VGKCs), which serve essential roles in the peripheral and central nervous systems and are known targets of pathological autoantibodies, were investigated in all layers of the human GI tract.Our findings suggest that currently recognised anti-channel antibodies are not a common pathogenic factor in primary GINMDs. Anti-channel antibodies, in particular anti-VGKC antibodies, were however found in a significant number of individuals with Chagas' disease. Furthermore, circulating factors in patients with chagasic GI disease altered GI smooth muscle contractility in vitro which may have pathological relevance to GI

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“…Varying rates of tumour presence at diagnosis of NMDAR encephalitis have been recorded. Dalmau et al reports this to be about 25% 9 while others report much lower rates 21,22 . Florence et al studying 81 patients found that 30% of women younger than 18 years, and less than 10% of girls younger than 14 years had tumours 12 .…”

Section: Association With Neoplasmsmentioning

confidence: 94%

Autoimmune encephalitis: An emerging entity

Ratnayake

2013

Sri Lanka J Child Health

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Anti-NMDA receptor encephalitis in Japan

Cited by 501 publications

References 19 publications

Autoinmune encephalitis associated to antibodies against the receptor N-methyl-D-aspartate: report of two cases

Autoinmune encephalitis associated to antibodies against the receptor N-methyl-D-aspartate: report of two cases

The role of humoral autoimmunity in gastrointestinal neuromuscular diseases

Autoimmune encephalitis: An emerging entity

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