Anti-nociceptive and anti-inflammatory properties of the leaf extracts of Hedranthera barteri in rats and mice

Onasanwo, SA; Elegbe, R.A.

doi:10.4314/ajbr.v9i2.48891

Cited by 33 publications

(41 citation statements)

References 17 publications

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“…These finding are in agreement with the reports of several literatures in which Viscum album was found to exhibits antinociceptive and antiinflammatory activities [20,27,28]. Intraperitoneal injection of acetic acid in this experiment produced abdominal contorsions by activating the chemosensitive nociceptors in the animals as reported by Onasanwo and Elegbe [29]. The percentage reduction in the number of abdominal contorsions indicates the level of analgesia in the acetic acid induced writhing reflex model [30].…”

Section: Discussionsupporting

confidence: 82%

Evaluation of Antinociceptive Activity of Ethanol Whole Plant Extract of Viscum Album L. In Rats

Wazis¹,

Sy²,

HB³

et al. 2016

J. Pharm. Sci. Innov.

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Viscum album L is widely distributed in tropical and subtropical Africa, Asia and Europe. They are used in the treatment of nervous complaints, bleeding, tumours, diabetes mellitus and arthritis. The study was conducted to evaluate the antinociceptive activitiy of the ethanol whole plant extract. The Preliminary phytochemical screening and acute toxicity study on the plant extract was carried out based on the outlined standard procedures, whereas the antinociceptive activity was evaluated using acetic acid-induced writhing and tail immersion test. The Preliminary phytochemical screening of the extract revealed the presence of flavonoids, alkaloids, glycosides, tannins, saponins, steriods and triterpenes. The intraperitoneal and oral LD50 was found to be greater than 2000 and 5000 mg/kg respectively. The ethanol extract of the plant produced significant (p<0.05) and dosedependent antinociceptive activity in both methods used. The peak antinociceptive effect occurred at 1000 mg/kg with a percentage inhibition of 88.3% in acetic acid-induced writhing test. Similarly 1000 mg/kg produced maximum increase in pain threshold by 1.91 fold in the tail immersion test at 90 minutes. The results demonstrate that the ethanol whole plant extract of Viscum album was found to be relatively less-toxic and contain some pharmacologically active constituents which might be responsible for the observed antinociceptive activity of the plant extract. These amply justify the traditional use of this plant as an analgesic.

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Section: Discussionsupporting

confidence: 82%

Evaluation of Antinociceptive Activity of Ethanol Whole Plant Extract of Viscum Album L. In Rats

Wazis¹,

Sy²,

HB³

et al. 2016

J. Pharm. Sci. Innov.

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“…Qualitative phytochemical screening showed the presence of flavonoids, tannins, and alkaloids in M. koenigii leaves extract which may be responsible for analgesic activity as all the three constituents are well known for their ability to inhibit pain perception [22][23][24][25][26]. However, qualitative phytochemical screening of C. sativum showed only presence of the flavonoids and polyphenols [27,28].…”

Section: Salwe Et Almentioning

confidence: 99%

“…i.p injection of acetic acid causes pain by liberating endogenous substances such as prostaglandins (PGs), serotonin, histamine, bradykinins, and substance P, which stimulate nerve endings [20]. Local peritoneal receptors are postulated to be involved in the abdominal constrictions response [21].…”

Section: Salwe Et Almentioning

confidence: 99%

Evaluation of Analgesic Activity of Murraya Koenigii and Coriandrum Sativum Leaves Extract in Animal Model.

J¹,

Mirunalini²,

Mano³

et al. 2018

Asian J Pharm Clin Res

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Objective: The objective of the study was to investigate the analgesic activity of hydroalcoholic extract of Murraya koenigii and Coriandrum sativum leaves and compared it with standard drug in an animal model. Methods:Hydroalcoholic extracts of M. koenigii and C. sativum leaves were obtained using Soxhlet apparatus. The central analgesic property was screened by hot plate method in mice and tail flick method in rats. The pain reaction time (PRT) was measured at 30, 60, and 120 min. The peripheral analgesic activity was evaluated by acetic acid induced writhing in mice. Results:In hot plate method M. koenigii leaves extract at both doses and tramadol showed significant increase in PRT at 30, 60, and 120 min compared with control group. C. sativum leaves extract showed significant increase in PRT only at 60 and 120 min compared to control group. In tail flick method M. koenigii leaves extract at both doses, higher dose of C. sativum leaves extract and tramadol showed significant increase in PRT at 30, 60, and 120 min compared with control group. Higher dose of M. koenigii leaves extract (200 mg/kg) was comparable with standard drug tramadol in both the methods. M. koenigii leaves extract at both dose showed significant reduction in the number of writhing but C. sativum leaves extract failed to show any significant reduction in the number of writhing compared with control. Higher dose of M. koenigii leaves extract was comparable with standard drug tramadol. Conclusion:M. koenigii leaves extract showed both peripheral and central analgesic effect while C. sativum leaves extract showed only peripheral analgesic effect.

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“…The chemical constituents of the extract were analyzed qualitatively and screened to detect saponins, flavonoids, alkaloids, and terpenoids by thin layer chromatography. [8,9] The extract was stored at -20ºC until pharmacological tests.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Antinociceptive and anti-inflammatory effects of roots extracts from Actinidia arguta (Sieb.et Zucc.) Planch

Teng¹,

Hong-sheng²,

Zhang³

2014

Phcog J.

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Aims: The roots of Actinidia arguta (Sieb. et Zucc.) Planch (also named tengligen) have medicinal uses as anti-tumour, antinociceptive, and anti-inflammatory agents. In this study, we evaluated the antinociceptive and anti-inflammatory effects of 95% ethanol extract and different fractions of the roots of A. arguta (Sieb.et Zucc.) Planch (Tengligen). Methods: Three conventional methods were used to carry out the antinociceptive effect: acetic acid-induced abdominal writhing, formalin induced hind paw licking, and hot plate test. In addition, the anti-inflammatory effect was investigated by carrageenan-induced paw edema in rats. Conclusion: From the obtained results, we found that the total ethanol extract, ethyl acetate fraction, and n-butanol fraction all significantly inhibited acetic acidinduced writhing and both phases of the formalin induced pain response, increased the time of response to thermal stimulation in hot plate test, and exhibited significant dose-related inhibition of carrageenan induced paw edema volumes when compared with the control group. Based on our findings, we conclude that the flavonoid and saponin contents of tengligen are responsible for the antinociception and anti-inflammatory effects of Actinidia arguta (Sieb. et Zucc.) Planch, respectively.

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Anti-nociceptive and anti-inflammatory properties of the leaf extracts of Hedranthera barteri in rats and mice

Abstract: Hedranthera barteri, HB (Apocynaceae) is a shrub in the closed

Cited by 33 publications

References 17 publications

Evaluation of Antinociceptive Activity of Ethanol Whole Plant Extract of Viscum Album L. In Rats

Evaluation of Antinociceptive Activity of Ethanol Whole Plant Extract of Viscum Album L. In Rats

Evaluation of Analgesic Activity of Murraya Koenigii and Coriandrum Sativum Leaves Extract in Animal Model.

Antinociceptive and anti-inflammatory effects of roots extracts from Actinidia arguta (Sieb.et Zucc.) Planch

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