Anti-Nociceptive, Anti-Inflammatory and Anti-Oxidant Effects of the Methanol Leaf Extract of Sterculia tragacantha Lindl

EVALUATION OF THE ANTI-ARTHRITIC EFFECT OF <I>STERCULIA TRAGACANTHA</I> (LINDL.) LEAF EXTRACT IN RATS

“…Traditionally, decoctions made from leaves, bark and seeds of Sterculia tragacantha (family: Sterculiaceae) tree are used in the treatment of arthritis, edema, gout and whitlow (Iwu, 1993). Recently the methanol extract of S. tragacantha extract was reported to possess analgesic, anti-inflammatory and in vitro anti-oxidant effects (Udegbunam et al, 2011). Therefore bearing in mind the antioxidant, analgesic and anti-inflammatory effects of S. tragacantha and its use in traditional medicine in the management of arthritis, we considered it worthwhile to investigate its anti-arthritic effect.…”

“…The leaves were air dried, pulverized and cold macerated in 80% methanol for 48 h at 37°C with intermittent shaking every 2 h. After 48 h the extract was filtered and evaporated to dryness in a rotary evaporator to obtain an extract (yield: 12.0%). Previously, phytochemical analysis of methanol extract of this plant revealed the presence of alkaloids, flavonoids, tannins, glycosides and saponins (Udegbunam et al, 2011). Doses used in this study were selected based on previous acute toxicity and anti-inflammatory studies (Udegbunam et al, 2011).…”

Sterculia and Brachychiton: a comprehensive overview on their ethnopharmacology, biological activities, phytochemistry and the role of their gummy exudates in drug delivery

“…In two similar studies, the Asuzu and Mogbojuri groups confirmed that the methanolic extract together with the chloroform and ethyl acetate extracts inhibited acetic acid-induced pain in a dose-dependent manner (100-600 mg/kg) comparable to indomethacin with no signs of toxicity or mortality. [28,38] In another interesting study, the methanolic extract inhibited nerve impulse conduction in the skin of guinea pigs and thus exerted local anaesthetic activity which reached 100% anaesthesia at a dose of 10 mg/ml using lignocaine as a positive control. The effect was due to the presence of alkaloids and saponins in the plant.…”

“…[37] The methanolic extract of S. tragacantha leaves (300 or 600 mg/kg) exhibited significant anti-inflammatory effect which was more potent than indomethacin (10 mg/ kg). [28] The extract effectively suppressed carrageenaninduced oedema in rats via the suppression of inflammatory mediators and inhibition of granuloma formation induced by cotton pellets in rats. Such findings indicated the significant anti-inflammatory activity of S. tragacantha leaves against acute and chronic inflammation which was also confirmed by another study carried out by Mogbojuri et al [38] The ethanolic extract of S. villosa bark was found to be beneficial in alleviating both acute and chronic inflammatory responses in a dose-dependent manner.…”

“…It also reduced ferric oxide with FRAP values of 1.34 and 1.63. The extract showed activity in a dose-dependent manner, and the results were compared to ascorbic acid, [28] whereas the activity of the aqueous acetone extract of S. setigera leaves and barks was compared to ascorbic acid used as the positive standard in FRAP assay. The activity of extract was 13.5 mmol AAE/g (ascorbic acid equivalent per gram of extract), which is higher than the reference ascorbic acid 5.58 mmol AAE/g.…”