Anti‐obesity action of Salix matsudana leaves (Part 1). Anti‐obesity action by polyphenols of Salix matsudana in high fat‐diet treated rodent animals

Abstract

In preliminary experiments, polyphenol fractions prepared from the leaves of Salix matsudana reduced the elevation of the rat plasma triacylglycerol level at 3 and 4 h after oral administration of a lipid emulsion containing corn oil, at a dose of 570 mg/kg. The present study examined the anti-obesity action of polyphenol fractions of S. matsudana leaves by testing whether the polyphenol fractions prevented the obesity induced by feeding a high-fat diet to female mice for 9 weeks. Body weights at 2-9 weeks and the fi nal parametrial adipose tissue weights were significantly lower in mice fed the high-fat diet with 5% polyphenols of S. matsudana leaves than in those fed the high-fat diet alone. The polyphenols of S. matsudana leaves also significantly reduced the hepatic total cholesterol content, which was elevated in mice fed the high-fat diet alone. In addition, the polyphenol fractions of S. matsudana leaves inhibited palmitic acid uptake into brush border membrane vesicles prepared from rat jejunum and alpha-amylase activity, and their fractions enhanced norepinephrine-induced lipolysis in fat cells. In conclusion, it is suggested that the inhibitory effects of the flavonoid glycoside fraction of S. matsudana leaves on high-fat diet-induced obesity might be due to the inhibition of carbohydrate and lipid absorption from small intestine through the inhibition of alpha-amylase and palmitic acid uptake into small intestinal brush border membrane or by accelerating fat mobilization through enhancing norepinephrine-induced lipolysis in fat cells.

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

“…210 To date no human studies have been carried out. 211,212 These studies showed that oral administration of polyphenol fractions to DIO mice reduced adiposity and body weight. In vitro analysis revealed that S. matsudana extract inhibited the enzyme α-amylase.…”

“…The effects of S. matsudana are mainly due to the inhibition of carbohydrate and lipid absorption, and the acceleration of fat mobilization through enhancement of NA-induced lipolysis in adipocytes. 211 Although S. matsudana extracts have been shown to have anti-obesity actions in vitro and in rodents, research in humans, especially on the long term effects, is lacking.…”

Anti-oxidant and anti-inflammatory effects of Salix Koreensis Andersson in DC. leaf methanol extract in vitro models

“…Moreover, Salix species also have anti-oxidant (Alam et al, 2006), anti-inflammatory (Li et al, 2008), antiobesity (Han et al, 2003), and anti-tumor (Sultana et al, 2004) effects. Salix Koreensis Andersson in DC.…”

Anti-hyperglycaemic and Anti-obesity Effects of Capparis spinosa and Chamaemelum nobile Aqueous Extracts in HFD Mice

“…The mechanism underlying the reported therapeutic activity may involve, at least, an improvement of insulin sensitivity which can lead to an increase in peripheral glucose utilization [16][17][18] . Scientific records reveal that plants such Panax ginseng [19,20] , Acanthopanax senticosus [21] , Salix matsudana [22] have been reported to posses insulin sensitizing activities in nutrition induced obese animals. A similar mechanism may operate in the plant extracts-treated HFD mice to improve glucose homeostasis.…”