Anti‐obesity activity of anthocyanin and carotenoid extracts from color‐fleshed sweet potatoes

Abstract

The anti-obesity effects of anthocyanin and carotenoid extracts from color-fleshed potatoes were studied with 3T3-L1 cells in vitro and high-fat diet (HFD)-induced obese mice in vivo. Treatment of 3T3-L1 adipocytes with anthocyanin and carotenoid extracts, respectively, after differentiation induction significantly inhibited fat accumulation by 63.1 and 83.5%. Studies of adipogenesis inhibition showed that the anthocyanin extract acts at intermediate stages, whereas the carotenoid extract influences all the stages. The extracts significantly diminished triglyceride (TG) content and peroxisome proliferator-activated receptor gamma (PPARγ) protein expression during adipogenesis of the intermediate stage. Oral administration of anthocyanin and carotenoid extracts, respectively, to HFD-fed mice significantly reduced weight gain and restored TG levels to normal or lower as compared to the HFD-fed group with improvement of a lipid profile, TG to HDL-C ratio. Histological differences in liver tissues revealed that the extracts protected the liver tissue from adipogenesis by HFD fed. This research presents the first direct demonstration that the two pigment extracts from sweet potato exhibit anti-obesity activities. Practical applications Anthocyanins and carotenoids are the main pigments of purple-and orange-fleshed sweet potatoes, respectively, which are highly nutritious foods with antidiabetic and antioxidant properties. Obesity is a rapidly growing health problem that increases major risk factors of several serious diseases including cardiovascular diseases, diabetes, and cancer. The results of this research suggest that anthocyanin and carotenoid-rich extracts from color-fleshed sweet potatoes may be useful as supplementary ingredients for the treatment of obesity and related diseases.

Protective Effect of Carotenoid Extract from Orange-Fleshed Sweet Potato on Gastric Ulcer in Mice by Inhibition of NO, IL-6 and PGE2 Production

“…For the analysis of carotenoid composition in orange-fleshed sweet potato, HPLC-DAD method was applied according to our previous report [20]. Briefly, 1 mg of each standard was dissolved in CH 2 Cl 2 (0.01% BHT, 10 mL) to make stock solution.…”

“…A medium level of orangefleshed sweet potato variety (100 g) can meet the daily needs of vitamin A for an early age generation [16]. Orange-fleshed sweet potato is known for its anti-oxidative, antidiabetic [17][18][19], and anti-obesity activities [20]. Regardless of the therapeutic effects of orange-fleshed sweet potatoes, the gastro-protective effects of carotenoid extract (CE) from orange-fleshed sweet potato have not been investigated.…”

Anti‐obesity effect of Auricularia heimuer fruiting body alcohol extraction on obese mice and crucial metabolite pathway analysis by liquid chromatography‐tandem mass spectrometry

“…Obesity is an abnormal condition that increases the risk of health problems by causing excessive accumulation of body fat (Guo et al., 2020). It is a high‐risk factor for a number of severe diseases including diabetes, arteriosclerosis, high blood pressure, circulatory diseases, and respiratory diseases (Kim, Koo, et al., 2020; Kim, Kim, et al., 2020; Terao et al., 2020). Among the various causes of obesity, the imbalance between energy storage and consumption is crucial (Gan et al., 2020; Wu, Guo, et al., 2020; Wu, Sun, et al., 2020).…”

“…Currently, obesity therapy depends on lifestyle interventions, such as diet control and exercise, but it is often difficult for patients to carry out (Joo et al., 2020; Zheng et al., 2020). However, a few drugs or surgical therapies, with certain risks, are suitable for severely obese patients (Behl et al., 2021), such as Orlistat, which has side effects, such as angioedema, bronchospasm, and allergic reactions (Kim, Koo, et al., 2020; Kim, Kim, et al., 2020). Therefore, there is an urgent need to investigate a safer and more effective strategy to prevent obesity (Ken and Samantha 2020), finding a promising natural product to treat obesity and metabolic disease has received increasing attention.…”

Intestinal Epithelial Monolayer Permeability of Sweet Potato-Derived Anthocyanin and Carotenoid Extracts in Caco-2 Cells

“…(C) An LC chromatogram of carotenoid extract obtained from 10 µL of the transport buffer prepared to be 0.5 mg/mL carotenoid extract. The peaks in the chromatogram were identified with external standards corresponding to each peak (Kim et al, 2020…”