Anti‐obesity and hypolipidemic effect of water extract from <i>Pleurotus citrinopileatus</i> in C57<scp>BL</scp>/6J mice

Sheng, Yao; Zhao, Changhui; Zheng, Shujuan; Mei, Xiaohong; Huang, Kunlun; Wang, Guoyi; He, Xiaoyun

doi:10.1002/fsn3.962

Cited by 43 publications

(26 citation statements)

References 29 publications

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“…The increase in the concentration of mycelial extract and the prolong treatment exposure significantly reduced the food intake of the nematodes, which suggest a loss of appetite and/or suppression of overeating. This observation is consistent with the recent study of Sheng et al [37], who reported that water extract from mushroom Pleurotus citrinopileatus significantly decreased the food intake resulting to the reduction of weight gain and fat accumulation in highfat diet-fed C57BL/6J mice. In addition, Khatun et al [38] reported that feeding of edible mushroom Echigoshirayukidake supplemented chow (5% w/w) significantly reduced the food intake and prevented body weight gain, fat deposition in the viscera, and hyperlipidemia in genetically defined obese model rat.…”

Section: In-vitro Activity Of L Strigosus Mycelial Extract In C Elesupporting

confidence: 93%

In-vitro activity of ethanolic extract of Lentinus strigosus mycelia in N2 wild strain Caenorhabditis elegans – An animal model for obesity and its chemical composition

Benditha¹,

Dulay²,

Arwen³

et al. 2021

J App Biol Biotech

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Lentinus strigosus is an edible and medicinal species of mushroom found in Central Luzon, Philippines. In the current study, the effects of ethanolic extract of L. strigosus mycelia (grown on coconut water in submerged culture) on the food intake and locomotion of Caenorhabditis elegans were investigated. Chemical compositions of the mushroom mycelia were likewise analyzed. Results showed that mycelial extract significantly reduced the food intake and increased the roaming and dwelling activities of extract-treated nematodes. The presently observed positive effects could not be accounted to the toxicity of the mycelial extract since the extract was confirmed safe in the acute lethality assay. In addition, mycelia of L. strigosus contained valuable mycochemicals such as flavonoids, alkaloids, terpenoids, steroids, phenols, saponins, athrones, anthraquinones, and coumarins, which have been reported to play important roles in the different mechanisms of anti-obesity activity. Accordingly, L. strigosus mycelium is a new addition of functional food resources, which has promising potential for the prevention of obesity and associated diseases.

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Section: In-vitro Activity Of L Strigosus Mycelial Extract In C Elesupporting

confidence: 93%

In-vitro activity of ethanolic extract of Lentinus strigosus mycelia in N2 wild strain Caenorhabditis elegans – An animal model for obesity and its chemical composition

Benditha¹,

Dulay²,

Arwen³

et al. 2021

J App Biol Biotech

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“…Fungi are known to produce a wealth of bioactive secondary metabolites and have a wide range of applications in agriculture, industrial, pharmaceuticals, and biomedical sectors (Fouda, Hassan, Eid, & Ewais, ; Sheng et al, ). To date, over 750 new metabolites from fungi have been described between 1993 and 2013, which confirms the tremendous potential of the fungal secondary metabolome (Keller, ).…”

Section: Discussionmentioning

confidence: 99%

Optimized production and safety evaluation of hispidin‐enriched Sanghuangporus sanghuang mycelia

Chen

Sheu

et al. 2020

Food Science & Nutrition

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Phellinus linteus, also known as the sanghuang mushroom, is a medicinal mushroom that has been recognized as beneficial to health for more thousands of years.Among its diverse valuable secondary metabolites, the yellow-brown styrylpyrone pigment hispidin has garnered significant attention due to its various pharmacological effects. However, recently after detailed morphological and molecular phylogenetic studies, the correct scientific name of the true sanghuang strains was shown not to be P. linteus but Sanghuangporus sanghuang. As the incorrect binomial name P. linteus has long been misleadingly referred, there is a need to evaluate the safety of S. sanghuang. Moreover, the growing conditions can impact the secondary metabolite profile of the fungi. Hence, this study is the first to optimize hispidin production and to investigate the genotoxic and oral toxic effects of hispidin-enriched S. sanghuang mycelia. In order to induce the biosynthesis of hispidin, 15 different culture media consisting of five carbon sources, five nitrogen sources, and five initial pH conditions were screened. Glucose and yeast extract at an initial pH of 5 were found to be the most suitable carbon and nitrogen sources, respectively, for the optimal growth and production of hispidin. Moreover, the production of hispidin was 3 mg/g in a 20-ton bioreactor under optimal conditions. Furthermore, the ames test, in vitro chromosome aberration test, acute oral toxicity test, and bone marrow micronucleus test were used to detect toxicological properties of 3 mg/g hispidin-enriched S. sanghuang mycelia. In all tests, there was no statistically significant difference between the mycelia and the negative control. Based on the results obtained, the present study demonstrates that 3 mg/g hispidin-enriched S. sanghuang mycelia has a very low order of toxicity, which supports its safety for human consumption. K E Y W O R D S hispidin, Phellinus linteus, safety assessment, Sanghuangporus sanghuang, toxicity | 1865 LI et aL.

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“…Taking into account that lipid-lowering drugs are the main strategy in treating atherosclerosis and that their side effects are important [7,8,10], the search for new hypolipidemic drugs with fewer side effects has drawn great attention in recent years [11,12]. In this context, some plants have been studied for their lipid-lowering effect in animal and human models [12,13]. The principal reason in interest on plants is their effectiveness in traditional medicine as remedy for dyslipidemia and cardiovascular complications [14].…”

Section: Introductionmentioning

confidence: 99%

Effect of polyphenol, flavonoid, and saponin fractions from Thymus atlanticus on acute and chronic hyperlipidemia in mice

Ramchoun¹,

Khouya²,

Harnafi³

et al. 2020

Futur J Pharm Sci

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Background Thymus atlanticus is an endemic plant of the Mediterranean region, which has been used in the Moroccan mountain area to treat several diseases. This study aimed to investigate the effect of polyphenol, flavonoid, and saponin fractions derived from this plant on acute and chronic hyperlipidemia in male albino mice. Results The results indicated that the injection of Triton WR-1339 (20 mg/100 g body weight (B.wt.)) and 6-week administration of a high-fat diet (which is an 81.8% standard diet supplemented with 2% cholesterol, 16% lard, and 0.2% cholic acid) significantly increased plasma total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C), but did not affect high-density lipoprotein cholesterol (HDL-C) levels in mice. Administration of a single dose (2 mg/kg B.wt.) of polyphenol, flavonoid, or saponin fractions significantly suppressed the effect of Triton injection on plasma total cholesterol, triglycerides, and LDL-C. In addition, the supplementation of the high-fat diet with polyphenol fraction (2 mg/kg B.wt./day) prevented the increase of total cholesterol, triglycerides, and LDL-C, and effectively increased HDL-C level when compared to mice feeding only the high-fat diet. Conclusion In conclusion, phenolic compounds from Thymus atlanticus possess a significant hypocholesterolemic and hypotriglyceridemic effects and, therefore, could have an important role in the management of dyslipidemia.

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Anti‐obesity and hypolipidemic effect of water extract from Pleurotus citrinopileatus in C57BL/6J mice

Cited by 43 publications

References 29 publications

In-vitro activity of ethanolic extract of Lentinus strigosus mycelia in N2 wild strain Caenorhabditis elegans – An animal model for obesity and its chemical composition

In-vitro activity of ethanolic extract of Lentinus strigosus mycelia in N2 wild strain Caenorhabditis elegans – An animal model for obesity and its chemical composition

Optimized production and safety evaluation of hispidin‐enriched Sanghuangporus sanghuang mycelia

Effect of polyphenol, flavonoid, and saponin fractions from Thymus atlanticus on acute and chronic hyperlipidemia in mice

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