Anti-obesity and Hypolipidemic effects of garlic oil and onion oil in rats fed a high-fat diet

Yang, Chao; Li, Lihua; Yang, Ligang; Hui, Lisa; Wang, Shaokang; Sun, Guiju

doi:10.1186/s12986-018-0275-x

Cited by 91 publications

(64 citation statements)

References 31 publications

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“…The animals in the high-fat diet group were considered obese when their body weight was 10% higher than the weight of animals in the control group. 18,19 Treatment Urolithin A and B (97% purity) were purchased from BLD Pharma, China. After the 10 weeks of feeding, animals in group 3 HFDA (HFD + Uro-A) and group 4 HFDB (HFD + Uro-B) were given an intraperitoneal (I.P.)…”

Section: Animalsmentioning

confidence: 99%

<p>Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet</p>

Abdulrahman

Kuerban

Alshehri

et al. 2020

DMSO

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Background: Urolithins are gut microbiota-derived polyphenol metabolites, produced following the consumption of pomegranate, berries, and nuts. Recent studies have shown the potentials of these metabolites on reducing triglycerides accumulation in cultured hepatocytes and adipocytes. In this study, we investigated the ability of both urolithin A (Uro-A) and urolithin B (Uro-B) to attenuate obesity and associated symptoms in a high-fat diet-induced obesity model in rats. Methods: Twenty-four male Wistar rats were randomly assigned to four groups. Group 1 was fed on a normal diet while groups 2, 3, and 4 were fed on a high-fat diet for 10 weeks. After this, groups 3 and 4 were treated with 2.5mg/kg body weight of Uro-A and Uro-B intraperitoneally, respectively. Body weight, serum lipid profile, hepatic antioxidant activity, hepatic lipid accumulation, fecal lipid content, and the expressions of genes involved in lipogenesis and hepatic ER stress were quantified. Results: Indeed, a high-fat diet resulted in increased body weight, visceral adipose tissue mass, and oxidative stress in rats. However, treatment with both Uro-A and Uro-B decreased body weight and visceral adipose tissue mass. These metabolites restored hepatic antioxidant capacity and decreased lipid accumulation in addition to an increase in fecal fat excretion. Moreover, both Uro-A and Uro-B treatment downregulated the expression of LXRα and SREBP1c; involved in de novo lipogenesis while upregulating PPARα expression for increased fatty acid oxidation. Furthermore, Uro-A and Uro-B decreased the expression of PERK and IRE1α; which are involved in hepatic ER stress. Taken together, our results showed the potentials of Uro-A and Uro-B in mitigating obesity symptoms and they could thus provide promising roles in the future as functional anti-obesity candidates.

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Section: Animalsmentioning

confidence: 99%

<p>Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet</p>

Abdulrahman

Kuerban

Alshehri

et al. 2020

DMSO

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“…DATS majorly involved in the activation of the ERK pathway and negatively regulate the adipogenic transcription factor expression during adipogenesis. These findings together suggested that garlic and its compounds could effectively reduce obesity by regulating the adipogenesis process [ 71 ].…”

Section: Biological Activities Of Sulfur Compounds From mentioning

confidence: 99%

Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate

et al. 2020

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Allium sativum (garlic) is widely known and is consumed as a natural prophylactic worldwide. It produces more than 200 identified chemical compounds, with more than 20 different kinds of sulfide compounds. The sulfide compounds particularly are proven to contribute to its various biological roles and pharmacological properties such as antimicrobial, antithrombotic, hypoglycemic, antitumour, and hypolipidemic. Therefore, it is often referred as disease-preventive food. Sulphur-containing compounds from A. sativum are derivatives of S-alkenyl-l-cysteine sulfoxides, ajoene molecules, thiosulfinates, sulfides, and S-allylcysteine. This review presents an overview of the water-soluble and oil-soluble sulphur based phytochemical compounds present in garlic, highlighting their mechanism of action in treating various health conditions. However, its role as a therapeutic agent should be extensively studied as it depends on factors such as the effective dosage and the suitable method of preparation.

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“…It is important to provide fluffy bread in a fermentation process [18]. Garlic has several functional compounds such as flavonoids and antioxidants [19]. In this study, it was suggested that some ingredients of garlic increased the fermentation ability of yeast.…”

Section: Characterization Of Seaweed Breadmentioning

confidence: 93%

Development of Novel Bread by Combining Seaweed Kappaphycus alvarezii from Sri Lanka and Saccharomyces cerevisiae Isolated from Nectarine

Komatsuzaki¹,

Arai²,

Fujihara³

et al. 2019

JAST-B

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Seaweeds are not used as much for edible use although many kinds of seaweed are collected in Sri Lanka. The objective of this study was to develop high quality bread using seaweed, Kappaphycus alvarezii collected from Sri Lanka, and wild yeast, Saccharomyces cerevisiae isolated from nectarine in Japan. Dietary fiber in K. alvarezii, Japanese sea weeds, Wakame and Aosa contained 48.1, 31.7 and 29.1 g/100 g, respectively. The amount of total organic acid increased in garlic bread compared to bread without garlic. The best swelling properties were evident in the bread with K. alvarezii (0.5%) and garlic. The bread including K. alvarezii increased the fermentative power of wild yeast while the addition of garlic increased the degree of swelling of the dough. In the sensory testing, the bread with K. alvarezii (0.5%) and garlic was favored for the fineness of its texture and had the most preferred texture. It is possible to develop seaweed bread that is rich in dietary fiber and has excellent flavor by adding a suitable amount of garlic during the fermentation process.

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Anti-obesity and Hypolipidemic effects of garlic oil and onion oil in rats fed a high-fat diet

Cited by 91 publications

References 31 publications

<p>Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet</p>

<p>Urolithins Attenuate Multiple Symptoms of Obesity in Rats Fed on a High-Fat Diet</p>

Prevailing Knowledge on the Bioavailability and Biological Activities of Sulphur Compounds from Alliums: A Potential Drug Candidate

Development of Novel Bread by Combining Seaweed Kappaphycus alvarezii from Sri Lanka and Saccharomyces cerevisiae Isolated from Nectarine

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