Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patch in high-fat diet-induced obese C57BL/6J mice

Dangol, Manita; Kim, S.; Li, Cheng Guo; Lahiji, Shayan Fakhraei; Jang, Mingyu; Ma, Yu-Seung; Huh, Inyoung; Jung, Hyungil

doi:10.1016/j.jconrel.2017.03.400

Cited by 91 publications

(58 citation statements)

References 23 publications

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“…Obesity usually accompanied with increase of total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) and a decrease of high-density lipoprotein cholesterol (HDL-C) in serum [5]. These four indicators had been widely used to validate obesity symptoms in various studies related to obesity [6–9]. Several pharmacotherapeutic agents, such as phentermine, have been employed to alleviate this complex disorder in recent decades.…”

Section: Introductionmentioning

confidence: 99%

Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice

Cui

Gao

et al. 2017

PLoS ONE

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Previous studies confirmed that dietary supplements of fish oil and krill oil can alleviate obesity in mice, but the underlying mechanism remains unclear. This study aims to discern whether oil treatment change the structure of the gut microbiota during the obesity alleviation. The ICR mice received high-fat diet (HFD) continuously for 12 weeks after two weeks of acclimatization with a standard chow diet, and the mice fed with a standard chow diet were used as the control. In the groups that received HFD with oil supplementation, the weight gains were attenuated and the liver index, total cholesterol, triglyceride and low-density lipoprotein cholesterol were reduced stepwise compared with the HFD group, and the overall structure of the gut microbiota, which was modulated in the HFD group, was shifted toward the structure found in the control group. Moreover, eighty-two altered operational taxonomic units responsive to oil treatment were identified and nineteen of them differing in one or more parameters associated with obesity. In conclusion, this study confirmed the effect of oil treatment on obesity alleviation, as well as on the microbiota structure alterations. We proposed that further researches are needed to elucidate the causal relationship between obesity alleviation and gut microbiota modulation.

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Section: Introductionmentioning

confidence: 99%

Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice

Cui

Gao

et al. 2017

PLoS ONE

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“…Articles demonstrating caffeine-caused weight loss are presented in Table 3. An already well-known mechanism of caffeine-mediated weight loss is also associated with its capacity of adenosine receptors antagonism [65] Thus, it increases energy expenditure [66,67] and promotes alertness [68,69]. Since T2DM has increased over recent decades [70], caffeine, owing to the abovementioned abilities [71,72], might be a part of the treatment.…”

Section: Dual Beneficial Role Of Caffeine For Obese Peoplementioning

confidence: 99%

Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO

2020

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Obesity is a worldwide prevalent metabolic disorder that is associated with diabetes, among many other diseases. Bearing this in mind, prevention and treatment ways need to be improved. Notably, activity of the enzyme semicarbazide-sensitive amine oxidase (SSAO) is found to be elevated in overweight subjects. Moreover, SSAO inhibition has resulted in an increase of histamine activity in adipose tissue and the limitation of body fat. The current review aims to overview the risks of obesity, rationalize the molecular ways of SSAO activity, and outline the strategies of inhibiting upregulated enzyme levels. It describes the differences between SSAO inhibitors and advances the prospective agents. Based on evidence, caffeine is proposed as an effective, safe, and reliable choice to inhibit SSAO activity. Furthermore, the histamine in adipocytes has been associated with SSAO activity. Therefore, it is suggested as one of the key compounds to be studied for obesity management. To conclude, inhibiting SSAO may attenuate weight gain and prevent related diseases.

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“…Peripheral administration of caffeine (by gavage) in diet-induced obese (DIO) mice reduced their food intake, increased wheel running activities, consumption of O 2 , and CO 2 production [ 26 ]. Other recent study demonstrated that C57BL6 mice that received caffeine showed a lipolysis improve which resulted in considerable weight loss [ 29 ]. Furthermore, the administration of caffeine to the mouse brain increased the number of c-Fos + cells in regions of the hypothalamus, such as the paraventricular nucleus (PVN), arcuate (Arc), and ventromedial and dorsomedial (DMH) nuclei.…”

Section: Resultsmentioning

confidence: 99%

Guarana (Paullinia cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet

et al. 2018

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The aim of this study was to evaluate the effects of guarana on mitochondrial biogenesis in a high-fat diet (HFD)-fed mice. C57BL6J mice were divided in two groups: high-fat diet HFD and high-fat diet + guarana (HFD-GUA). Both groups received HFD and water ad libitum and the HFD-GUA group also received a daily gavage of guarana (1 g/kg weight). Body weight and food intake was measured weekly. Glycemic, triglyceride, and cholesterol levels were determined. VO2 and energy expenditure (EE) were determined by indirect calorimetry. Gene expression was evaluated by real-time PCR and protein content by western blotting. The HFD-GUA group presented lower body weight, subcutaneous, retroperitoneal, visceral, and epididyimal adipose tissue depots, and glycemic and triglyceride levels, with no change in food intake and cholesterol levels. Furthermore, the HFD-GUA group presented an increase in VO2 and basal energy expenditure (EE), as well as Pgc1α, Creb1, Ampka1, Nrf1, Nrf2, and Sirt1 expression in the muscle and brown adipose tissue. In addition, the HFD-GUA group presented an increase in mtDNA (mitochondrial deoxyribonucleic acid) content in the muscle when compared to the HFD group. Thus, our data showed that guarana leads to an increase in energetic metabolism and stimulates mitochondrial biogenesis, contributing to control of weight gain, even when associated with high-fat diet.

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Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patch in high-fat diet-induced obese C57BL/6J mice

Cited by 91 publications

References 23 publications

Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice

Modulation of the gut microbiota by the mixture of fish oil and krill oil in high-fat diet-induced obesity mice

Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO

Guarana (Paullinia cupana) Stimulates Mitochondrial Biogenesis in Mice Fed High-Fat Diet

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