Anti‐obesity effect of a standardised ethanol extract from Curcuma longa L. fermented with Aspergillus oryzae in ob/ob mice and primary mouse adipocytes

Abstract

These results suggest that supplementation of FTE has potent anti-obesity effects by controlling body weight, fat mass, serum lipids, and hepatic lipids. Moreover, FTE could be considered a potential resource for the treatment of obesity through its promotion of lipolysis via the protein kinase A pathway.

Effect of turmeric on glycemic status, lipid profile, hs‐CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients

“…Animal studies also showed that body weight and adipose tissue decreased with curcumin treatment (Ho et al, ). It seems that turmeric can increase lipolysis via protein kinase‐A pathway (Ho et al, ). Also, curcumin increases fatty acids oxidation.…”

“…In Minpei kuroda et al study, 0.2 or 1.0 g/100 g diet (260 and 1,500 mg/kg body weight) of turmeric extract in the diet of diabetic mice for 4 weeks prevented the blood glucose elevation and improved insulin resistance (Kuroda et al, ). In the study of Ho et al, 200, or 500 mg/kg body weight curcumin ethanol extract in the diet of obese mice for 9 weeks led to weight loss and improved lipid profile (Ho et al, ).…”

Anti-adipogenic effect of a turmeric extract-loaded nanoemulsion in 3T3-L1 preadipocytes and high fat diet-fed mice

“…These findings are consistent with our data demonstrating the anti-adipogenic activity of TENE, which leads to reduced lipid accumulation in a cellular model. The data suggest that TENE may act by regulating cellular differentiation, which makes it suitable as a potential therapeutic agent for obesity (Ho et al, 2012;Song & Choi, 2016).…”

“…When cells were incubated in the presence of a range of concentrations of TENE (0, 1, 2, 5, 10, or 30 μg/mL) for 24 h, a toxic effect of TENE was not observed up to 10 μg/mL; therefore, 10 μg/mL TENE was used in subsequent experiments ( Figure 1A). Because turmeric extract is a potential therapy for obesity (Ho et al, 2012;Septembre-Malaterre et al, 2016), we assessed whether TENE might affect adipogenesis in 3T3-L1 adipocytes. When 3T3-L1 cells were treated with MDO for 8 days, intracellular lipid content was significantly increased, according to Dil Red D staining.…”

A New Germacrane-Type Sesquiterpene from Fermented Curcuma longa L.

“…Currently, fermented C. longa L. is known to reduce bitterness and harsh taste, improving the flavor and taste and providing an increase of consumption. 7 So far, several pharmacological effects of fermented C. longa, including hepatoprotective 8 and anti-obesity 9 have been reported whereas little is known about the chemical components of fermented C. longa extract. In the present study, five compounds, including one new sesquiterpene (1) were isolated from the fermented C. longa extract by application of various chromatographic methods.…”