Anti-obesity Effect of Halophyte Crop, &lt;i&gt;Limonium tetragonum&lt;/i&gt; in High-Fat Diet-Induced Obese Mice and 3T3-L1 Adipocytes

Kim, Nahyun; Heo, Jeong‐Doo; Rho, Jung‐Rae; Yang, Min; Jeong, Eun Ju

doi:10.1248/bpb.b17-00296

Cited by 18 publications

(13 citation statements)

References 38 publications

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“…However, during T2DM, the metabolic regulation of WAT results in impaired adipogenesis and lipolysis, eventually leading to WAT over‐expansion and excessive lipid accumulation . Both adipogenesis and lipolysis are driven by the regulatory networks of transcription factors, involving peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), CCAAT/enhancer binding protein‐α (C/EBP‐α) and sterol regulatory element‐binding protein 1 c (SREBP‐1 c) . There is a growing body of evidence indicating that chronic low‐grade inflammation in adipose tissue is associated with obese T2DM, particularly insulin resistance .…”

Section: Introductionmentioning

confidence: 99%

A novel berberine‐metformin hybrid compound exerts therapeutic effects on obese type 2 diabetic rats

Jia

Li²,

Zhou

et al. 2019

Clin Exp Pharma Physio

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Summary In this study, we investigated the biological activities of a novel berberine‐metformin hybrid compound (BMH473) as an anti‐diabetic agent. BMH473 exhibited significant anti‐hyperglycaemic and anti‐hyperlipidaemic effects on T2DM rats. In white adipose tissue, BMH473 reduced the perirenal and epididymal adipose tissue mass and modulated the lesions in perirenal adipose tissue, by inhibiting the protein expressions of PPAR‐Ɣ, C/EBP‐α and SREBP‐1c as well as the mRNA expressions of lipogenic genes. Moreover, BMH473 downregulated the levels of pro‐inflammatory cytokines in perirenal adipose tissue through the suppression of p‐NF‐κB. In liver, BMH473 reduced liver ectopic fat accumulation, by regulating the protein expression levels of SREBP‐1c and PPAR‐α as well as the mRNA expression levels of lipogenic genes. In addition, BMH473 inhibited hepatic gluconeogenesis by promoting the phosphorylation levels of AMPK α and ACC, and down‐regulating the mRNA expression levels of FBPase, G6Pase and PEPCK. Furthermore, BMH473 exhibited significant inhibitory effects on lipogenesis and lipid accumulation in 3T3‐L1 adipocytes by modulating the protein expression levels of PPAR‐Ɣ, C/EBP‐α and SREBP‐1 c as well as the mRNA expression levels of lipogenic genes. In conclusion, our results suggest that the newly synthesized BMH473 is beneficial for maintaining glucose and lipid homeostasis in type 2 diabetic rats, and exhibits better anti‐hyperlipidaemic effects compared to metformin and berberine.

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Section: Introductionmentioning

confidence: 99%

A novel berberine‐metformin hybrid compound exerts therapeutic effects on obese type 2 diabetic rats

Jia

Li²,

Zhou

et al. 2019

Clin Exp Pharma Physio

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“…Pancreatic lipase performs the hydrolysis of 50–70% of total dietary fats. Thus, inhibiting pancreatic lipases will reduce the number of fats absorbed by the intestine [ 12 , 47 ]. Obesity, a chronic metabolic disease, is caused by excessive fat intake and accumulation.…”

Section: Resultsmentioning

confidence: 99%

“…Bioactivity studies have shown that various Limonium species possess free radical scavenging, antioxidant, antimicrobial, antiviral, anti-inflammatory, anticancer, immunomodulatory, hepatoprotective, anti-melanogenic, anti-obesity and enzyme inhibitor activities, and so on. [ 8 , 9 , 10 , 11 , 12 , 13 ]. In addition to the therapeutic importance of the genus Limonium , some species have ornamental value because of attractive flowers, some are consumed as foods and some are used as antioxidants in cosmetic products [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Phenolic Compounds by LC-MS/MS and Evaluation of Bioactive Properties of Two Edible Halophytes: Limonium effusum and L. sinuatum

et al. 2021

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This work aimed to evaluate the phenolic content and in vitro antioxidant, antimicrobial and enzyme inhibitory activities of the methanol extracts and their fractions of two edible halophytic Limonium species, L. effusum (LE) and L. sinuatum (LS). The total phenolic content resulted about two-fold higher in the ethyl acetate fraction of LE (522.82 ± 5.67 mg GAE/g extract) than in that of LS (274.87 ± 1.87 mg GAE/g extract). LC-MS/MS analysis indicated that tannic acid was the most abundant phenolic acid in both species (71,439.56 ± 3643.3 µg/g extract in LE and 105,453.5 ± 5328.1 µg/g extract in LS), whereas hyperoside was the most abundant flavonoid (14,006.90 ± 686.1 µg/g extract in LE and 1708.51 ± 83.6 µg/g extract in LS). The antioxidant capacity was evaluated by DPPH and TAC assays, and the stronger antioxidant activity in ethyl acetate fractions was highlighted. Both species were more active against Gram-positive bacteria than Gram negatives and showed considerable growth inhibitions against tested fungi. Interestingly, selective acetylcholinesterase (AChE) activity was observed with LE and LS. Particularly, the water fraction of LS strongly inhibited AChE (IC50 = 0.199 ± 0.009 µg/mL). The ethyl acetate fractions of LE and LS, as well as the n-hexane fraction of LE, exhibited significant antityrosinase activity (IC50 = 245.56 ± 3.6, 295.18 ± 10.57 and 148.27 ± 3.33 µg/mL, respectively). The ethyl acetate fraction and methanol extract of LS also significantly inhibited pancreatic lipase (IC50 = 83.76 ± 4.19 and 162.2 ± 7.29 µg/mL, respectively). Taken together, these findings warrant further investigations to assess the potential of LE and LS as a bioactive source that can be exploited in pharmaceutical, cosmetics and food industries.

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“…Limonium tetragonum is a salt-tolerant biennial halophyte of the Plumbaginaceae family that grows widely in salt marshes and on muddy seashores along the southwestern coastal areas of South Korea. L. tetragonum possesses anti-oxidative properties and has been reported to have multiple beneficial effects against various pathologies such as high-fat diet-induced obesity [ 24 ] and alcohol-induced liver damage in mice [ 25 ], and diethylnitrosamine-induced liver fibrosis in rats [ 26 ]. In vitro studies have demonstrated that L. tetragonum extract suppresses the melanogenesis of B16-F10 melanoma cells [ 27 ] and the proliferation of HSC-T6 hepatic stellate cells, and inhibits matrix metalloproteinase activity in HT1080 fibrosarcoma cells [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Limonium tetragonum Promotes Running Endurance in Mice through Mitochondrial Biogenesis and Oxidative Fiber Formation

et al. 2022

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The purpose of this study was to examine whether Limonium tetragonum, cultivated in a smart-farming system with LED lamps, could increase exercise capacity in mice. C57BL/6 male mice were orally administered vehicle or Limonium tetragonum water extract (LTE), either 30 or 100 mg/kg, and were subjected to moderate intensity treadmill exercise for 4 weeks. Running distance markedly increased in the LTE group (100 mg/kg) by 80 ± 4% compared to the vehicle group, which was accompanied by a higher proportion of oxidative fibers (6 ± 6% vs. 10 ± 4%). Mitochondrial DNA content and gene expressions related to mitochondrial biogenesis were significantly increased in LTE-supplemented gastrocnemius muscles. At the molecular level, the expression of PGC-1α, a master regulator of fast-to-slow fiber-type transition, was increased downstream of the PKA/CREB signaling pathway. LTE induction of the PKA/CREB signaling pathway was also observed in C2C12 cells, which was effectively suppressed by PKA inhibitors H89 and Rp-cAMP. Altogether, these findings indicate that LTE treatment enhanced endurance exercise capacity via an improvement in mitochondrial biosynthesis and the increases in the formation of oxidative slow-twitch fibers. Future study is warranted to validate the exercise-enhancing effect of LTE in the human.

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Anti-obesity Effect of Halophyte Crop, <i>Limonium tetragonum</i> in High-Fat Diet-Induced Obese Mice and 3T3-L1 Adipocytes

Cited by 18 publications

References 38 publications

A novel berberine‐metformin hybrid compound exerts therapeutic effects on obese type 2 diabetic rats

A novel berberine‐metformin hybrid compound exerts therapeutic effects on obese type 2 diabetic rats

Identification of Phenolic Compounds by LC-MS/MS and Evaluation of Bioactive Properties of Two Edible Halophytes: Limonium effusum and L. sinuatum

Limonium tetragonum Promotes Running Endurance in Mice through Mitochondrial Biogenesis and Oxidative Fiber Formation

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