Anti-Obesity Effect of Porcine Collagen Peptide in 3T3-L1 Adipocytes and High-Fat Diet-Fed Mice by Regulating Adipogenesis

Lee, Eunji; Bang, Jiyoung; Jun, Woojin; Lee, Yoo‐Hyun

doi:10.1089/jmf.2022.k.0025

Cited by 7 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…41 It has been reported that CPs prevented obesity via modulating gut microbiota, inhibiting adipocyte differentiation, and regulating lipogenesis and lipolysis. 42,43 This study further demonstrated that CPs activated NHR-80/FAT-6 pathway, by which the stored fat was hydrolyzed to stearic acid by lysosomal lipase, and then converted into oleic acid by delta-9 desaturase. As far as the authors are aware knowledge, this was the first demonstration that CPs can delay the aging process by activating the NHR-80/FAT-6 pathway to regulate the lipid metabolism.…”

Section: Nhr-80/fat-6 Pathway Of Cps In C Elegansmentioning

confidence: 61%

Collagen peptides from sturgeon swim bladder prolong the lifespan and healthspan in Caenorhabditis elegans

Wang,

Li,

Zheng

et al. 2024

J Sci Food Agric

View full text Add to dashboard Cite

BACKGROUNDSturgeon is a popular aquaculture species in many countries. Its swim bladder is rich in collagen, but has not been exploited scientifically yet.RESULTSCollagen peptides (CPs) from sturgeon swim bladder by trypsinolysis are 528.5 Da in number‐average molecular weight, and consisted of 407 peptides, of which GFPGADGSAGPK was 16.1% in content. The CPs at 25 mg/mL extended the lifespan of Caenorhabditis elegans by 22.6%, which was significantly higher than other hydrolysis methods and source materials. They also improved the fitness‐related traits (body size, motor capacity, oxidative stress, cell apoptosis and epidermal barrier function), indicating the prolonged healthspan. Further, transcriptome analysis showed that the effect was mediated by MAPK pathway to enhance stress resistance, insulin/IGF‐1 pathway to inhibit protein aggregation, and NHR‐80/FAT‐6 pathway to regulate lipid metabolism.CONCLUSIONCPs from sturgeon swim bladder by trypsinolysis prolonged the lifespan and healthspan in Caenorhabditis elegans, and might be promising anti‐aging agents.This article is protected by copyright. All rights reserved.

show abstract

Section: Nhr-80/fat-6 Pathway Of Cps In C Elegansmentioning

confidence: 61%

Collagen peptides from sturgeon swim bladder prolong the lifespan and healthspan in Caenorhabditis elegans

Wang,

Li,

Zheng

et al. 2024

J Sci Food Agric

View full text Add to dashboard Cite

show abstract

“…This can be possibly explained by mechanisms. Firstly, collagen peptides have an anti-obesity effect (49). Adipogenesis is the process of converting 3T3-L1 preadipocytes into adipocytes (50).…”

Section: Discussionmentioning

confidence: 99%

“…This process is regulated by activators such as C/EBPa and PPARγ (51). Collagen peptide treatment signi cantly downregulated the expression of C/EBPα and PPARγ, leading to a reduction in adipogenic differentiation (49). Secondly, unlike the placebo group, the collagen group was able to maintain their resting energy expenditure (REE) due to the preservation and increase of FFM, which is considered to have played an important role (52).…”

Section: Discussionmentioning

confidence: 99%

Effects of collagen supplementation on body composition and muscle strength in Korean adults aged 50 years and older

Park

2023

Preprint

View full text Add to dashboard Cite

BACKGROUND: Insufficient protein intake can accelerate the loss of muscle mass as one ages. A decrease in muscle mass leads to an increase in fat mass, creating a vicious cycle that can result in sarcopenic obesity. Previous studies that have used collagen as a supplementation, which accounts for about 30% of the body's protein, have combined it with resistance exercise. OBJECTIVE: This study investigated the effects of collagen supplementation on body composition in individuals over the age of 50, while maintaining their daily activity levels constant. DESIGN: Double-blind randomized controlled trial PARTICIPANTS: Participants were assigned to either the collagen group (n=42) or the placebo group(n=42). MEASUREMENTS: Collagen supplementation (14g of collagen) and placebo product (xanthan gum) were offered to collagen group and placebo group respectively, once a day. Body composition was measured by bioelectrical impedance analysis and dual-energy X-ray absorptiometry. Participants were instructed to maintain their dietary intake and physical activity levels, which were evaluated through a 3-day food record analysis and an international physical activity questionnaire (IPAQ) analysis, respectively. RESULTS: 74 participants in the collagen group (n=37) and placebo group (n=37) completed the follow-up, and there was no significant difference between the two groups in terms of physical activity levels. The collagen group showed a significant reduction in total body fat mass compared to the placebo group, as evidenced by both BIA (P=0.021) and DEXA (P=0.041) measurements. However, there was no significant difference between the two groups in terms of muscle mass. Conclusion: From this study, the consumption of collagen supplementation is effective in reducing fat mass, which is significant in preventing sarcopenic obesity after middle age.

show abstract

“…Collagen peptides have an anti-obesity effect (32). Adipogenesis is the process of converting 3T3-L1 preadipocytes into adipocytes (33).…”

Section: Discussionmentioning

confidence: 99%

“…This process is regulated by activators such as C/EBPa and PPARγ (34). Collagen peptide treatment significantly downregulated the expression of C/EBPα and PPARγ, leading to a reduction in adipogenic differentiation (32). The collagen utilized in this study was a hydrolyzed low molecular collagen peptide extracted from porcine, which closely resembles human collagen (7) and comprises functional peptides that demonstrate physiological activity.…”

Section: Discussionmentioning

confidence: 99%

Effects of 12 weeks of low molecular collagen peptide supplementation on body composition in overweight Korean adults aged 50 years and older

Park

2023

Preprint

View full text Add to dashboard Cite

After the age of 50, their muscle mass gradually declines each year, and the lost muscle is often replaced by fat mass. Insufficient protein intake after middle age further accelerates this process. Previous studies that have used collagen as a supplementation, which accounts for about 30% of the body's protein, have combined it with resistance exercise. This study investigated the effects of collagen supplementation on body composition in individuals over the age of 50 (23≤BMI≤32), while maintaining their daily activity levels constant. Participants were assigned to either the collagen group (n=42) or the placebo group(n=42). Collagen supplementation (15g of collagen) and placebo product (xanthan gum) were offered. Bioactive Collagen Peptides, which is a type of low molecular weight collagen extracted from porcine raw materials, was used. Body composition was measured by bioelectrical impedance analysis and dual-energy X-ray absorptiometry. Blood samples were taken for analysis. Physical activities and dietary intake were measured by international physical activity questionnaire and a 3-day food record, respectively. 74 participants in the collagen group (n=37) and placebo group (n=37) were used in the final analysis. Physical activity and dietary intake showed no significant difference between the two groups. The collagen group showed a significant reduction in total body fat mass compared to the placebo group, as evidenced by both BIA (P=0.021) and DEXA (P=0.041) measurements. There were no significant differences in blood measurements between the two groups. Therefore, the intake of collagen supplementation after middle age may be used for preventing age related fat mass accumulation.

show abstract

Anti-Obesity Effect of Porcine Collagen Peptide in 3T3-L1 Adipocytes and High-Fat Diet-Fed Mice by Regulating Adipogenesis

Cited by 7 publications

References 27 publications

Collagen peptides from sturgeon swim bladder prolong the lifespan and healthspan in Caenorhabditis elegans

Collagen peptides from sturgeon swim bladder prolong the lifespan and healthspan in Caenorhabditis elegans

Effects of collagen supplementation on body composition and muscle strength in Korean adults aged 50 years and older

Effects of 12 weeks of low molecular collagen peptide supplementation on body composition in overweight Korean adults aged 50 years and older

Contact Info

Product

Resources

About