Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice

Kim, Hye-Lin; Ahn, You Mee; Lee, So Min; Seo, Chang‐Seob; Park, Seonghwan; Bang, Ok‐Sun; Jung, Jeeyoun

doi:10.3390/nu14142929

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…However, moderation is vital, and it's essential to combine sweet potatoes with other nutrient-rich foods and engage in regular physical activity to achieve and maintain a healthy weight. Consult a healthcare professional or a registered dietitian for personalized advice regarding individual nutrient needs and dietary restrictions [220][221][222][223][224].…”

Section: Obesitymentioning

confidence: 99%

Sweetpotatoes: The Super Food of the Next Century? An Intensive Review on Their Potential as a Sustainable and Versatile Food Source for Future Generations

Islam

2024

Preprint

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This review article aims to delve into several aspects of sweetpotatoes and their leaves, including their nutritional composition, health benefits, culinary uses, and potential future implications as a superfood. It suggests an in-depth exploration of sweet potatoes' history, status, and prospects, highlighting their significance and potential economic value. Sweetpotatoes, often referred to as a powerhouse of nutrients, have gained popularity recently due to their remarkable nutritional composition and versatile culinary uses. This starchy root vegetable comes from the Convolvulaceae family and is consumed worldwide, playing a significant role in diverse cultures and cuisines. Besides their vibrant colors ranging from orange to purple, sweetpotatoes offer many health benefits, making them an essential addition to a well-balanced diet. Its extraordinary nutritional profile and numerous health benefits make it a superfood. Incorporating it into the diet can improve digestion, strengthen immunity, and reduce the risk of chronic diseases. With their versatility in the kitchen, there is no deficiency of charming and healthy recipes to explore. So, make room for sweet potatoes on your plate and unlock their vast potential to enhance your overall health and well-being. Overall, the future of sweetpotatoes looks bright as research and innovation aim to improve their nutritional value, adapt them to changing climate conditions, develop new varieties and products, and promote sustainable production practices. These developments can contribute to food security, economic growth, and healthier diets. Future research should focus on nutritional composition, health benefits, sustainable farming practices, cultivar development, and industrial applications to ensure sustainable and efficient production. By prioritizing research in these areas, we can enhance the utilization of sweet potatoes in various fields and secure their future for the next century.

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Section: Obesitymentioning

confidence: 99%

Sweetpotatoes: The Super Food of the Next Century? An Intensive Review on Their Potential as a Sustainable and Versatile Food Source for Future Generations

Islam

2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Abdominal obesity patients are often associated with pathological conditions such as X-syndrome and act as a powerful risk factor for early arteriosclerosis, ischemic cardiovascular disease and cerebrovascular disease [4][5][6]. The high-fat and high-sugar diet is related to cause of hyperlipidemia [7]. Kang et al reported that high-fat-induced obesity altered cognition and anxiety related behavior.…”

Section: Introductionmentioning

confidence: 99%

Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice

Park

Lee

et al. 2022

IJERPH

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Background: Chitoglucan (CG) is a bioactive component obtained from Flammulina velutipes Sing, an edible mushroom, which is known to have an anti-obesity effect. However, its biological and hormonal activities in alleviating obesity through regulation of adipocyte-derived proteins have not been examined yet. Purpose: The present study aimed to investigate the anti-obesity effects of chitoglucan and its hormonal mechanisms in high-fat diet (HFD)-induced mice. Methods: The mice were fed either a normal diet (Normal group) or a high fat diet (HFD group) over 6 weeks. The HFD fed mice were administered with saline (HFD group), adipex (HFD + adipex group), chitoglucan 50, 150, or 300 mg/kg/day for 3 weeks (HFD + CG groups). The food consumption, body weight, fat contents, and the levels of serum leptin and resistin were assessed after treatment of chitoglucan. Results: the HFD produced a marked increase in body and fat weights after 6 weeks of feeding compared with the Normal group. Administration of chitoglucan for 3 weeks tended to reduce body weight and significantly decreased parametrical adipose tissues in HFD groups. The level of serum leptin in the HFD group was markedly higher than that in the Normal group, whereas the level of leptin in the chitoglucan treated groups was significantly decreased in comparison with the HFD group. In addition, the level of serum resistin in high-fat diet group tended to be more increased than Normal group. However, the serum resistin level was significantly reduced in HF diet groups after treatment with chitoglucan (50 mg/kg or 150 mg/kg). Conclusion: Collectively, these data suggest that chitoglucan from the Flammulina velutipes may be useful in the treatment of high diet-induced obesity and metabolic syndrome.

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Two Triterpenoids, ARM‐2 and RA‐5, From Protorhus longifolia Exhibit the Potential to Modulate Lipolysis and Lipogenesis in Cultured 3T3‐L1 Adipocytes

Ndlovu,

Serem,

Bester

et al. 2024

Journal of Lipids

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Triterpenoids have been identified as potential novel lipid‐lowering drugs for the treatment of hypertriglyceridemia. This study investigated the potential antilipogenic and/or antilipolytic effects of two triterpenoids (ARM‐2 and RA‐5) isolated from the stem bark of Protorhus longifolia (Benrh.) Engl. Employing a combination of in silico predictions and in vitro assays, the interactions between these triterpenoids and key proteins involved in lipogenesis and lipolysis were investigated. In silico molecular docking analysis predicted a favourable binding affinity of both triterpenoids to PPARγ, SREBP‐1, and AMPK, with lower binding affinity to C/EBPα, pancreatic lipase, and hormone‐sensitive lipase (HSL). Both triterpenoids exhibited in vitro inhibition of pancreatic lipase with Ki and IC50 values ranging from 28.7 to 52.9 μM and 27.6 to 35.8 μM, respectively. Total and neutral lipid accumulation in differentiated 3T3‐L1 adipocytes and the oleic acid–induced HepG2 cell model was inhibited, with ARM‐2 showing better inhibition than RA‐5. In the HepG2 model, the inhibitory activity of the two triterpenoids (at 25 and 100 μM) was comparable to 50 μM lovastatin, although the latter was cytotoxic, whereas both ARM‐2 and RA‐2 lacked cytotoxicity. Associated gene expression was similar to the effect of simvastatin where the expression of SREBP‐1, PPARγ, C/EBPα, and HSL was reduced and that of AMPK was unchanged. In vitro studies confirmed that ARM‐2 and RA‐5 also inhibited adipocyte lipolysis, where the reduction in glycerol release by 25 and 100 μM was similar to 50 μM lovastatin and simvastatin. This study identifies that the triterpenoids, ARM‐2 and RA‐5, have the potential to modulate lipogenesis and lipolysis.

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Anti-Obesity Effects of Aqueous Extracts of Sunbanghwalmyung-Eum in High-Fat- and High-Cholesterol-Diet-Induced Obese C57BL/6J Mice

Cited by 4 publications

References 28 publications

Sweetpotatoes: The Super Food of the Next Century? An Intensive Review on Their Potential as a Sustainable and Versatile Food Source for Future Generations

Sweetpotatoes: The Super Food of the Next Century? An Intensive Review on Their Potential as a Sustainable and Versatile Food Source for Future Generations

Anti-Obesity Effect of Chitoglucan in High-Fat-Induced Obesity Mice

Two Triterpenoids, ARM‐2 and RA‐5, From Protorhus longifolia Exhibit the Potential to Modulate Lipolysis and Lipogenesis in Cultured 3T3‐L1 Adipocytes

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