Anti-obesity effects of corn peptide on 3T3-L1 preadipocytes and C57BL/6J obese mice

Corn Oligopeptide Alleviates Nonalcoholic Fatty Liver Disease by Regulating the Sirtuin Signaling Pathway

“…6,8,10 CP may exert a protective effect against NAFLD by reducing hepatic lipid accumulation, improving mitochondrial dysfunction, and ameliorating oxidative stress in HFD-fed mice. 13,14 This evidence strongly indicates that CP is a promising compound for mitigating NAFLD in preclinical disease models. In this study, we comprehensively investigated the protective effects of CP against lipid accumulation, hepatic injury, inflammation, and fibrosis.…”

“…Considerable attention has been devoted to the multiple physiological activities of natural active ingredients. In recent years, accumulating evidence has demonstrated the pharmacological effects of food-derived bioactive peptides in the treatment of metabolic syndrome. , The protective role of CP against other types of liver injury, such as immunological and alcohol-induced damage, has also been well documented. ,, CP may exert a protective effect against NAFLD by reducing hepatic lipid accumulation, improving mitochondrial dysfunction, and ameliorating oxidative stress in HFD-fed mice. , This evidence strongly indicates that CP is a promising compound for mitigating NAFLD in preclinical disease models. In this study, we comprehensively investigated the protective effects of CP against lipid accumulation, hepatic injury, inflammation, and fibrosis.…”

“…CP protects the liver against alcohol-induced oxidative stress by increasing antioxidant levels and preventing lipid peroxidation . Furthermore, CP was recently reported to regulate lipid metabolism and exert therapeutic effects against nonalcoholic fatty liver disease (NAFLD) by ameliorating mitochondrial dysfunction. − Mitochondrial dysfunction has been demonstrated to serve as an upstream factor in liver inflammation and contribute to the progression of NASH . These data suggest that CP is a promising candidate for NAFLD and NASH treatment.…”

Optimising decolourization and nitrogen component properties of corn protein hydrolysate: impact of activated carbon dosage and pH

“…However, its poor solubility and deficiency in essential AA, such as lysine and tryptophan, has confined its usage, mostly for animal feed. In contrast, the enzymatic hydrolysis of CGM presents a promising solution to enhance its solubility, resulting in peptides with diverse functional properties, including antioxidant (Yu et al ., 2023), hepatoprotective (Yao et al ., 2022), antihypertensive (Zhang et al ., 2023), and alcohol metabolism‐promoting activities (Zhu et al ., 2019), and enhanced economic value (He et al ., 2018). However, it is important to note that CGM contains lutein, and Maillard reaction products can be generated during enzymatic hydrolysis when exposed to heat.…”