Anti-obesity Effects of Tae-Um-Jo-Wee-Tang and Do-Dam-Tang in Female Rats with Diet-induced Obesity

Park, Sunmin; Ahn, Il-Sung; Kim, Dasol; Kang, Suna; Kwon, Dae-Young; Yang, Hye‐Jeong

doi:10.3839/jabc.2010.008

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…Consistent with this histology, marked decreases in hepatic FA, triglyceride, and cholesterol contents, and increased hepatic activities of CPT, were seen after TJ treatment, with simultaneous decreases in HMGCR activity, which is the primary means for controlling cholesterol biosynthesis. Part of this result was consistent with a preceding study that demonstrated that hepatic triglyceride content was significantly lowered by TJ [ 24 ]. Moreover, decreased plasma GOT and GPT levels were measured in TJ-treated mice, indicative of the reduced liver damage induced by HFD.…”

Section: Discussionsupporting

confidence: 92%

Metabolic Effect of an Oriental Herbal Medicine on Obesity and Its Comorbidities with Transcriptional Responses in Diet-Induced Obese Mice

Choi

Kim

Cho

et al. 2017

IJMS

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Taeeumjowuitang (TJ) is an alternative herbal medicine that has been used to treat obesity in Korea. The molecular mechanisms involved in TJ-induced anti-obesity effects have not yet been determined. The aim of the current study was to elucidate the effects of TJ on obesity and metabolic syndrome, by analyzing the transcriptional and metabolic responses to TJ treatment. C57BL/6J mice were fed a high-fat or high-fat + 3% (w/w) TJ diet for 12 weeks. Their phenotypic characteristics were measured and the anti-obesity mechanism was elucidated, based on the RNA sequencing (RNA-seq) transcriptomic profiles in an animal model of obesity. TJ treatment ameliorated insulin resistance, dyslipidemia, and hepatic steatosis in high-fat diet-induced obese mice, with a simultaneous reduction in body weight gain by enhancing energy expenditure and suppressing adiposity. An analysis of the global transcriptional changes by RNA-seq revealed that TJ upregulated mitochondrial oxidative phosphorylation-associated genes in epididymal white adipose tissue (eWAT), suggesting an enhanced mitochondrial function after TJ treatment. Moreover, TJ effectively attenuated the high-fat diet-induced inflammatory response through transcriptional changes in eWAT. Our findings provide some mechanistic insights into the effects of TJ, an alternative oriental medicine, in the treatment of obesity and its comorbidities. They demonstrate that metabolic and transcriptional responses to diet-induced obesity with TJ treatment were desirable in adipose tissue metabolism.

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Section: Discussionsupporting

confidence: 92%

Metabolic Effect of an Oriental Herbal Medicine on Obesity and Its Comorbidities with Transcriptional Responses in Diet-Induced Obese Mice

Choi

Kim

Cho

et al. 2017

IJMS

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“…Among numerous anti-obesity herbal medicines, Taeumjowitang (TH) is a decoction consisting of eight herbal ingredients which has traditionally been used as an herbal medicine in Korea to treat dyspepsia, stuffiness, the sensation of fullness, diarrhea, and wind stroke [27][28][29][30]. Earlier reports have demonstrated effects of TH and its modified prescription on obesity and hyperlipidemia [27][28][29][30][31][32] but mechanistic studies are needed for its therapeutic application.…”

Section: Introductionmentioning

confidence: 99%

Hepatic proteome and its network response to supplementation of an anti-obesity herbal mixture in diet-induced obese mice

Kim

Park

Chaudhari

et al. 2015

Biotechnol Bioproc E

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In the present study, we investigated the effects of multi-herbal water extract mixture, Taeumjowi-tang (TH) on liver proteome alteration in mice using twodimensional electrophoresis combined with MALDI-TOF-MS. Animals were fed high-fat diet with or without TH (0.3% wt/wt) supplement for 12 weeks. At the end of 5 th week of experimental diet, mice fed high-fat diet only were subdivided into 2 groups, obesity-prone (OP) and obesityresistant (OR) mice based on weight gain. OR mice gained less body weight compared to OP mice despite of same food intake. TH significantly suppressed weight gain, and proteomic analysis enabled the identification of 49 liver proteins showing differential regulation between OP and OR/TH mice. Combined results of proteomic and western blot analyses revealed decreased lipogenesis via three fatty acid metabolic targets (AMPK, ACC, and FAS) in livers of OR and TH mice. Using bioinformatic classification and network analysis, most of the identified proteins were classified as hydrolases, oxidoreductases, transferases, defense/immunity proteins, and enzyme modulators based on functional analysis of the PANTHER classification system. Combined results of proteomic and bioinformatic analyses using GeneMANIA identified two proteins (LACTB2 and NIT2) in the liver that potentially interact with fatty acid metabolic proteins. Furthermore, these proteins were included in acetylation, phosphoprotein, and metabolic processes in DAVID classification. These proteins were highly expressed in OP mice; however both their transcription and protein expression were lowered by TH treatment. In conclusion, combined data from proteomic and network analyses suggest that TH exerts anti-obesity effects by modulating fatty acid metabolic proteins/genes, particularly via the AMPK pathway. Most targeted proteins/ genes were modulated toward enhancing lipid metabolism in response to TH treatment.

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“…If the current trend continues, the obese population will be 700 million in 2015 and one-third of the world population in 2025. The most recent Korean National Health and Nutrition Examination Survey (KNHANES) found that 35.2% of male adults, 28.6% of female adults, and 31.9% of adults aged over 19 were overweight according to BMI calculations [2]. Westernized eating habits, such as an increased intake of fat, salt, and sugar, have played a large part in the increasing number of obese individuals in Korea.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults: A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial

Park

Nahmkoong

Cheon

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Objective. The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. Methods. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (n = 57) group or the placebo group (n = 55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition. Results. The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed (P = 0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group (P < 0.0001). There were no significant changes in both within groups and between groups for lipid profile and body fat composition. No adverse event was reported in either group. Conclusion. Although the difference between the groups regarding a rate of subjects who lost 5% or more of initial weight did not show statistical significance, TJ001 appears to be beneficial in safely controlling weight.

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Anti-obesity Effects of Tae-Um-Jo-Wee-Tang and Do-Dam-Tang in Female Rats with Diet-induced Obesity

Cited by 8 publications

References 18 publications

Metabolic Effect of an Oriental Herbal Medicine on Obesity and Its Comorbidities with Transcriptional Responses in Diet-Induced Obese Mice

Metabolic Effect of an Oriental Herbal Medicine on Obesity and Its Comorbidities with Transcriptional Responses in Diet-Induced Obese Mice

Hepatic proteome and its network response to supplementation of an anti-obesity herbal mixture in diet-induced obese mice

Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults: A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial

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