Anti-Obesity Potential of Heritiera Fomes Leaves Methanolic Extract in a Preclinical Model

Mirza, M.; Ali, Sayed Ayaz; Sanghvi, I S

doi:10.9790/3008-1204010105

Cited by 2 publications

(3 citation statements)

References 18 publications

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“…[9] Previous studies have revealed that it had beneficial effects in treating T2DM [10] and that its bark and leaves had antidiabetic activity. [11,12] In this study, we intended to investigate the in vitro and in vivo antihyperglycemic activity of ethanol extract of H. fomes (EEHF) bark to further understand the mechanisms contributing to such activity [7] and provide additional scientific evidence to support the ethnomedicinal use of this plant as an antidiabetic agent.…”

Section: Discussionmentioning

confidence: 99%

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In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules

Ansari

Azam

Seidel

et al. 2022

Journal of Pharmacy and Pharmacology

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Objective This study aimed to demonstrate the mechanistic basis of Heritiera fomes, which has traditionally been used to treat diabetes. Methods Clonal pancreatic β-cells and primary islets were used to measure insulin release. 3T3-L1 cells were used to analyse insulin action, and in vitro systems were used to measure further glucose-lowering activity. In vivo assessment was performed on streptozotocin (STZ)-induced type-2 diabetic rats and reversed-phase-HPLC followed by liquid chromatography mass spectrometry (LC-MS) to detect bioactive molecules. Key findings Ethanol extract of Heritiera fomes (EEHF) significantly increased insulin release with stimulatory effects comparable to 1 µM glucagon-like peptide 1, which were somewhat reduced by diazoxide, verapamil and calcium-free conditions. Insulin release was stimulated by tolbutamide, isobutyl methylxanthine and KCl. EEHF induced membrane depolarization and increased intracellular Ca2+ levels. EEHF enhanced glucose uptake in 3T3L1 cells and decreased protein glycation. EEHF significantly inhibited postprandial hyperglycaemia following sucrose loading and inversely elevated unabsorbed sucrose concentration in the gut. It suppressed glucose absorption during in situ gut perfusion. Furthermore, EEHF improved glucose tolerance, plasma insulin and gut motility, and decreased plasma dipeptidyl peptidase IV activity. Procyanidins, epicatechin and proanthocyanidins were some of the identified bioactive constituents that may involve in β-cell actions. Conclusions This study provides some evidence to support the use of H. fomes as an antidiabetic traditional remedy.

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Section: Discussionmentioning

confidence: 99%

“…[10] Other studies on the bark and leaves have demonstrated antidiabetic and cardioprotective activity. [11,12] The plant also has remarkable antioxidant, [9] antinociceptive, antimicrobial [13] and anticancer activity. [14] However, the specific mechanisms behind the glucose-lowering effects remain uncertain.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules

Ansari

Azam

Seidel

et al. 2022

Journal of Pharmacy and Pharmacology

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“…[111] An experimental study on albino rats, reported that dose-dependent administration of H. fomes leaf extract significantly reduces body and organ weight with management of cholesterol. [138] The ethanolic extract of the leaf of E. agallocha was found to be a potential inhibitor of elastage and collagenase activity at a concentration of 80 μg/mL. [139]…”

Section: Other Therapeutic Activitiesmentioning

confidence: 99%

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Das

Jena

et al. 2022

Chemistry & Biodiversity

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Bhitarkanika National Park is the second largest contiguous mangrove forest of India. Approximately 0.15 million mangrove depending population are found residing in and around 307 villages within the National Park. Despite being one of the most diverse mangrove habitations of India, the ethnopharmacological practices are meager in comparison to the other mangrove regions of India and Southeast Asia. The present review is aimed to congregate information on the therapeutic potential and ethnopharmacology of nine dominant mangrove species of the National Park, such as Aegiceras corniculatum, Avicenia marina, Avicenia officinalis, Ceriops decandra, Excoecaria agallocha, Heritiera fomes, Lumnitzera racemosa, Rhizophora mucronata, and Sonneratia apetala. Our aim is to generate social awareness among the mangrove dwellers to promote uses of folklore medicine using these tremendously potential mangrove plants, as a complementary step to strengthen community health. Further, we also want to grab the attention of researchers working in related disciplines, for their holistic and extensive studies towards bio-prospectation of the dominant mangrove plants of Bhitarkanika National Park.

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Anti-Obesity Potential of Heritiera Fomes Leaves Methanolic Extract in a Preclinical Model

Cited by 2 publications

References 18 publications

In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules

In vitro and in vivo antihyperglycemic activity of the ethanol extract of Heritiera fomes bark and characterization of pharmacologically active phytomolecules

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

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