Anti-obesity property of the brown seaweed, Sargassum polycystum using an in vivo animal model

Awang, Afzan Naquiah; Ng, Ju Lynn; Matanjun, Patricia; Sulaiman, Mohd Rosni; Tan, Tek Song; Ooi, Yasmin Beng Houi

doi:10.1007/s10811-013-0149-6

Cited by 29 publications

(15 citation statements)

References 29 publications

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“…It has also been reported to have antioxidant and antiinflammatory properties (Peng, Yuan, Wu, & Wang, 2011;Sachindra et al, 2007) as well as anti-cancer activity (Kumar, Hosokawa, & Miyashita, 2013;Moghadamtousi et al, 2014). Moreover, recent studies have reported anti-obesity and antidiabetic properties associated with the consumption of fucoxanthin (Awang et al, 2014;Maeda, Hosokawa, Sashima, Murakami-Funayama, & Miyashita, 2009). Fucoxanthin therefore has considerable potential as a nutraceutical ingredient that could be incorporated into functional food and beverage products.…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo study of fucoxanthin bioavailability from nanoemulsion-based delivery systems: Impact of lipid carrier type

Salvia‐Trujillo

Sun

et al. 2015

Journal of Functional Foods

106

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Available online A B S T R A C TThe impact of carrier oil type on the functionality of a lipophilic nutraceutical (fucoxanthin) encapsulated within nanoemulsions was investigated. Three carrier oils were investigated: long chain triacylglycerols (LCT); medium chain triacylglycerols (MCT); and indigestible oil (orange/mineral oil). Nanoemulsions containing LCT and MCT were completely digested under simulated gastrointestinal conditions, whereas those containing indigestible oil were not digested. Fucoxanthin solubility in mixed micelles formed by in vitro digestion decreased in the following order: LCT > MCT > indigestible oil. Animal feeding studies revealed that fucoxanthin was absorbed into the intestinal epithelial cells in the same order as observed for the in vitro solubility. However, the concentration of fucoxanthin in the serum of the rats was similar for all carrier oils. The present work highlights the importance of contrasting in vitro and in vivo experiments to assess the biological fate of functional ingredients incorporated in emulsion-based delivery systems.

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Section: Introductionmentioning

confidence: 99%

In vitro and in vivo study of fucoxanthin bioavailability from nanoemulsion-based delivery systems: Impact of lipid carrier type

Salvia‐Trujillo

Sun

et al. 2015

Journal of Functional Foods

106

View full text Add to dashboard Cite

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“…For example, feeding of seaweed powder of Sargassum polycystum suppressed weight gain in rats fed with high fat diet and reduced the plasma levels of cholesterol and triacylglycerols [20]. In another study, feeding of the brown seaweed Undaria pinnatifida showed positive effects on body weight gain, energy consumption, and serum levels of glucose and insulin in diet-induced obese mice [21].…”

Section: Seaweeds As Food and Their Potential Anti-obesity Effectsmentioning

confidence: 99%

Marine Algae as a Potential Source for Anti-Obesity Agents

2016

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Obesity is a major epidemic that poses a worldwide threat to human health, as it is also associated with metabolic syndrome, type 2 diabetes and cardiovascular disease. Therapeutic intervention through weight loss drugs, accompanied by diet and exercise, is one of the options for the treatment and management of obesity. However, the only approved anti-obesity drug currently available in the market is orlistat, a synthetic inhibitor of pancreatic lipase. Other anti-obesity drugs are still being evaluated at different stages of clinical trials, while some have been withdrawn due to their severe adverse effects. Thus, there is a need to look for new anti-obesity agents, especially from biological sources. Marine algae, especially seaweeds are a promising source of anti-obesity agents. Four major bioactive compounds from seaweeds which have the potential as anti-obesity agents are fucoxanthin, alginates, fucoidans and phlorotannins. The anti-obesity effects of such compounds are due to several mechanisms, which include the inhibition of lipid absorption and metabolism (e.g., fucoxanthin and fucoidans), effect on satiety feeling (e.g., alginates), and inhibition of adipocyte differentiation (e.g., fucoxanthin). Further studies, especially testing bioactive compounds in long-term human trials are required before any new anti-obesity drugs based on algal products can be developed.

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“…We are particularly concerned with the presence of photosynthetic pigments which have curative effect against leading cause of death such as cardiovascular disease (CVD). Some studies have obviously indicated the healing power of both macroalgae [7][8][9][10][11][12] and microalgae [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Hypocholesterolemic Effect and Pigments Composition of Herbal Medicine Containing Higher and Lower Plants

Limantara

Indrawati

Wijaya

et al. 2017

Int J Pharm Pharm Sci

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Objective: The objective of this research was to investigate the antihypercholesterolemic activity of herbal medicine which consisted of pigmentrich simplicia from higher and lower plants, as well as to determine its pigments composition.Methods: Sprague-Dawley male rats were randomly divided into five cholesterol-rich diet groups as well as one negative control group with a normal diet, in order to investigate its effect on plasma lipid. The new herbal formulation was administered orally to induced-rats at three dosage levels, whereas simvastatin was used as a comparable generic drug. Pigments composition was determined by means of reversed-phase highperformance liquid chromatography (HPLC) using gradient protocol, monitored with diode array detector at 430 nm. Results:The administration of herbal medicine was able to significantly reduce total plasma cholesterol and low-density lipoprotein-cholesterol (p<0.05) at a dose of 312.5 mg/kg of body weight/day compared to positive control group, and hence the atherogenic index was also lowered. The chromatographic analysis of pigments determination and quantification are reported correspondingly to support the possible active compounds data of hypocholesterolemic property. Conclusion:The results obtained in this research work indicated the potency of pigment-rich lower plants to substitute the obtrusive exploration and dominant use of higher plants for treating dyslipidemia.

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Anti-obesity property of the brown seaweed, Sargassum polycystum using an in vivo animal model

Cited by 29 publications

References 29 publications

In vitro and in vivo study of fucoxanthin bioavailability from nanoemulsion-based delivery systems: Impact of lipid carrier type

In vitro and in vivo study of fucoxanthin bioavailability from nanoemulsion-based delivery systems: Impact of lipid carrier type

Marine Algae as a Potential Source for Anti-Obesity Agents

Hypocholesterolemic Effect and Pigments Composition of Herbal Medicine Containing Higher and Lower Plants

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