Anti-opioid effects of neuropeptide FF receptors in the ventral tegmental area

Kersanté, Flavie; Wang, Jinya; Chen, Jin-Chung; Mollereau, Catherine; Zajac, Jean‐Marie

doi:10.1016/j.neulet.2010.11.052

Cited by 19 publications

(9 citation statements)

References 32 publications

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“…NPFF inhibits morphine‐induced conditioned place preference . Complementary to this, the putative NPFFR2 agonist dNPA completely abolished opiate‐induced dopamine and serotonin release in the nucleus accumbens .…”

Section: Anti‐opioid Effects Of the Npffr Systemmentioning

confidence: 73%

What's in a Name? Roles of RFamide‐Related Peptides Beyond Gonadotrophin Inhibition

Kim

2016

J Neuroendocrinology

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RFamide-related peptides (RFRPs) have been heavily implicated in the control of reproductive function subsequent to their discovery more than 16 years ago. However, recent studies using genetic and pharmacological tools have challenged their importance in regulating the hypothalamic-pituitary-gonadal axis. It is generally accepted that RFRPs act as part of a wider RFamide system, which involves two receptors, called the neuropeptide FF receptors (NPFFR1 and R2), and includes the closely-related neuropeptide NPFF. NPFF has been studied ever since the 1980s and many of the functions of NPFF are also shared by RFRPs. The current review questions whether these functions of NPFF are indeed specific to just NPFF alone and presents evidence from both neuroendocrine and pharmacological perspectives. Furthermore, recently emerging new functions of RFRPs are discussed with the overall goal of clarifying the functions of RFRPs beyond the hypothalamic-pituitary-gonadal axis.

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Section: Anti‐opioid Effects Of the Npffr Systemmentioning

confidence: 73%

What's in a Name? Roles of RFamide‐Related Peptides Beyond Gonadotrophin Inhibition

Kim

2016

J Neuroendocrinology

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“…Nociception is the physiological function in which this interaction between NPFF and opioids has been the most extensively studied; notwithstanding that reward, locomotion, feeding and intestinal motility are also affected. The presence of both NPFF-like immunoreactive material and NPFF binding sites in the mesolimbic structures [ 209 , 220 ] may point toward the involvement of NPFF in drug addiction processes. In fact, it also suggests that NPFF may be a good candidate for directly or indirectly regulating mesocorticolimbic system activity.…”

Section: Anti-opioidsmentioning

confidence: 99%

“…Furthermore, NPFF i.c.v. administration reduces the sensitization to hyperlocomotor effects that is crucial in the development of morphine [ 220 , 222 ], heroin [ 224 ], cocaine [ 225 ], as well as amphetamine [ 223 ] and ethanol dependence [ 222 ]. These data show that NPFF receptors may be involved not only in the rewarding, but also in the motivational effects of many drugs of abuse.…”

Section: Anti-opioidsmentioning

confidence: 99%

Crosstalk between Opioid and Anti-Opioid Systems: An Overview and Its Possible Therapeutic Significance

Gibuła‐Tarłowska

Kotlińska

2020

Biomolecules

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Opioid peptides and receptors are broadly expressed throughout peripheral and central nervous systems and have been the subject of intense long-term investigations. Such studies indicate that some endogenous neuropeptides, called anti-opioids, participate in a homeostatic system that tends to reduce the effects of endogenous and exogenous opioids. Anti-opioid properties have been attributed to various peptides, including melanocyte inhibiting factor (MIF)-related peptides, cholecystokinin (CCK), nociceptin/orphanin FQ (N/OFQ), and neuropeptide FF (NPFF). These peptides counteract some of the acute effects of opioids, and therefore, they are involved in the development of opioid tolerance and addiction. In this work, the anti-opioid profile of endogenous peptides was described, mainly taking into account their inhibitory influence on opioid-induced effects. However, the anti-opioid peptides demonstrated complex properties and could show opioid-like as well as anti-opioid effects. The aim of this review is to detail the phenomenon of crosstalk taking place between opioid and anti-opioid systems at the in vivo pharmacological level and to propose a cellular and molecular basis for these interactions. A better knowledge of these mechanisms has potential therapeutic interest for the control of opioid functions, notably for alleviating pain and/or for the treatment of opioid abuse.

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“…Furthermore, NPFF is known to be involved in water balance [47,53,54] and with NPSF and NPAF affects adipogenesis [55]. Moreover recent investigations in rodents describe NPFF to be involved in locomotion and reward [56-59]. Central injections of NPFF in mice evoked hypothermic effects [60-62] and could be antagonized by BIBP3226 as well as by RF9 [63,64].…”

Section: Physiological Effects Of Rfamide Peptidesmentioning

confidence: 99%

RFamide Peptides: Structure, Function, Mechanisms and Pharmaceutical Potential

2011

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Different neuropeptides, all containing a common carboxy-terminal RFamide sequence, have been characterized as ligands of the RFamide peptide receptor family. Currently, five subgroups have been characterized with respect to their N-terminal sequence and hence cover a wide pattern of biological functions, like important neuroendocrine, behavioral, sensory and automatic functions. The RFamide peptide receptor family represents a multiligand/multireceptor system, as many ligands are recognized by several GPCR subtypes within one family. Multireceptor systems are often susceptible to cross-reactions, as their numerous ligands are frequently closely related. In this review we focus on recent results in the field of structure-activity studies as well as mutational exploration of crucial positions within this GPCR system. The review summarizes the reported peptide analogs and recently developed small molecule ligands (agonists and antagonists) to highlight the current understanding of the pharmacophoric elements, required for affinity and activity at the receptor family. Furthermore, we address the biological functions of the ligands and give an overview on their involvement in physiological processes. We provide insights in the knowledge for the design of highly selective ligands for single receptor subtypes to minimize cross-talk and to eliminate effects from interactions within the GPCR system. This will support the drug development of members of the RFamide family.

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Anti-opioid effects of neuropeptide FF receptors in the ventral tegmental area

Cited by 19 publications

References 32 publications

What's in a Name? Roles of RFamide‐Related Peptides Beyond Gonadotrophin Inhibition

What's in a Name? Roles of RFamide‐Related Peptides Beyond Gonadotrophin Inhibition

Crosstalk between Opioid and Anti-Opioid Systems: An Overview and Its Possible Therapeutic Significance

RFamide Peptides: Structure, Function, Mechanisms and Pharmaceutical Potential

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