Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate

Jeong, Yong Seok; Kim, Inhye; Cho, Joon Hyung; Park, Dae Won; Kwon, Jae Wan; Jung, Moon Won; Xue, Meng; Jo, Se Min; Song, Hae Seong; Cho, Young Mi; Song, Sang Mok; Ham, Young-Min; Jung, Yong‐Hwan; Kim, Chang-Sook; Yoon, Weon‐Jong; Kang, Se Chan

doi:10.1371/journal.pone.0134856

Cited by 27 publications

(17 citation statements)

References 30 publications

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“…In the progression of OA, NF-κB is a transcriptional factor that can be triggered by a number of stimuli, such as cytokines, excessive mechanical stress and degradation products of ECM [28]. Activated NF-κB regulates several catabolic enzymes involved in matrix degradation, including MMPs [28, 33]. MMP-3 has been shown to break down a number of ECM proteins, including fibronectin, laminin, denatured collagens and proteoglycans [28].…”

Section: Discussionmentioning

confidence: 99%

New herbal composition (OA-F2) protects cartilage degeneration in a rat model of collagenase induced osteoarthritis

Nirmal

Jagtap

Narkhede

et al. 2017

BMC Complement Altern Med

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BackgroundPrevalence of osteoarthritis (OA) is on rise on the global scale. At present there are no satisfactory pharmacological agents for treating OA. Our previous study showed that Sida cordifolia L. and Zingiber officinale Rosc. had protective effect on cartilage. Here, we describe the effect of OA-F2, a herbal formulation prepared using combination of these two plants in alleviating OA associated symptoms in a rat model of collagenase-induced OA.MethodsOA was induced by intra-articular injection of collagenase type II in wistar rats. Diclofenac (10 mg/kg) was used as a reference control. Rats (n = 6) were divided into 6 groups: Healthy control (HC), osteoarthritic control (OAC), diclofenac (DICLO), OA-F2L (135 mg/kg), OA-F2M (270 mg/kg) and OA-F2H (540 mg/kg). The effects of the 20 days treatment were monitored by parameters like knee diameter, paw volume, paw retraction; serum C-reactive protein (CRP), alkaline phosphatase (ALP) and glycosaminoglycan (GAG). Radiography and histopathology of knee joint were also studied. Additionally, gene expression was studied from isolated synovium tissue proving anti-osteoarthritic potential of OA-F2.ResultsOral administration of OA-F2 has significantly prevented knee swelling compared to OAC; OA-F2 and DICLO, significantly reduced paw volume compared to OAC. Paw latency was remarkably increased by OA-F2 compared to OAC. OA-F2L (−0.670, p < 0.001), M (−0.110, p < 0.05) and H (0.073) has markedly reduced levels of CRP compared to DICLO. OA-F2L (p < 0.05), M (p < 0.001) and H (p < 0.05) significantly reduced ALP levels, compared to DICLO. GAG release in the serum was also significantly lowered in OA-F2 treated group compared to DICLO. Radiological and histopathological observations showed cartilage protection by OA-F2. OA-F2 has upregulated SOD and GPx. Upregulated CAT expression was observed in OA-F2M and H. Considerable down-regulation of expression of MMP-3 and MMP-9 was observed in all the groups. Up-regulation of TIMP-1 was observed in rats treated with OA-F2L, H and DICLO.ConclusionOA-F2 has shown therapeutic effects in rat model of collagenase induced OA by demonstrating cartilage protection through controlling MMPs and improving anti-oxidant levels in arthritic synovium and is a potent candidate for further drug development and treatment for OA.

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Section: Discussionmentioning

confidence: 99%

New herbal composition (OA-F2) protects cartilage degeneration in a rat model of collagenase induced osteoarthritis

Nirmal

Jagtap

Narkhede

et al. 2017

BMC Complement Altern Med

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“…OA resulted in destruction of articular cartilage which ends with impaired joint motion and disability (Arjmandi et al, 2014). Many causative aspects contributed in OA development; some of them are inflammation, proteinases and reactive oxygen or nitrogen species (ROS/RNS) generation which ultimately led to synovitis (Berenbaum, 2013;Narayani et al, 2014;Ferrándiz et al, 2015;Jeong et al, 2015). Most commonly prescribed pharmaceuticals modalities used for treating OA are symptomatic; however, it is not block or reverse the cartilage and joint destructions besides their side effects (Akhtar and Haqqi, 2012).…”

Section: Discussionmentioning

confidence: 99%

Prospective Effect of Red Algae,actinotrichia Fragilis, Against Some Osteoarthritisaetiology

Sayed¹,

Sadek²,

Soliman³

et al. 2016

AJTCAM

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Background: Osteoarthritis (OA) is a progressive disease characterized by joints pain and articular cartilage destruction. Most of the current treatment strategies for OA are effective for symptoms relief but are accompanied with adverse side effect. Thus, the present investigation aims to evaluate the potential influence of red algae, Actinotrichia fragilis, in the dry powder form (AFP) or gel form (AFG) on some relevant factors of OA progression as well as assess its safety through in vitro and in vivo experiments. Materials and Methods: In vitro, AFP was analyzed for its chemical constituents screening, amino acid, proteinase inhibitory activity, HRBC membrane stabilization activity, free radical scavenging activity, total antioxidant potency, nitric oxide radical scavenging power. In vivo, Organization for Economic Co-operation and Development (OECD) toxicity test was performed to test the safety of AFP on rats.Results: The present findings revealed that AFP and AFG can be considered as inflammatory-proteinase-oxidant inhibitor and considered to be safe according to the OECD guideline. Conclusion: AFP and AFG may have the potency to become the therapeutic candidate for OA disease as it prevents the key causes of OA initiation.

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“…The qualities of Litsea (genus of the Laurel family, Lauraceae), mostly in the form of the ethanolic (EtOH) or hexane fragmentations of the plant, as an antioxidant agent with anti-inflammatory characteristics, have been evaluated, inter alia, within the setting of OA [52][53][54][55][56][57][58]. Data reported from in vitro research, investigating the anti-inflammatory assets of a variety of fractions (EtOH or other) of this plant within the context of lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, suggest a considerable inhibitory activity of the intervention on modulators of inflammation (NO and PGE 2 , iNOS, and COX-2), expression levels, along with pro-inflammatory cytokines, IL-1β, IL-6, TNF-α, and NF-κB (p65 and p50) activation, and mitogen-activated protein kinase (MAPK) phosphorylation [52][53][54].…”

Section: Litsea Japonicamentioning

confidence: 99%

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

et al. 2020

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The natural process of aging gradually causes changes in living organisms, leading to the deterioration of organs, tissues, and cells. In the case of osteoarthritis (OA), the degradation of cartilage is a result of both mechanical stress and biochemical factors. Natural products have already been evaluated for their potential role in the prevention and treatment of OA, providing a safe and effective adjunctive therapeutic approach. This review aimed to assess the therapeutic potential of natural products and their derivatives in osteoarthritis via a systematic search of literature after 2008, including in vitro, in vivo, ex vivo, and animal models, along with clinical trials and meta-analysis. Overall, 170 papers were obtained and screened. Here, we presented findings referring to the preventative and therapeutic potential of 17 natural products and 14 naturally occurring compounds, underlining, when available, the mechanisms implicated. The nature of OA calls to initially focus on the management of symptoms, and, in that context, several naturally occurring compounds have been utilized. Underlying a global need for more sustainable natural sources for treatment, the evidence supporting their chondroprotective potential is still building up. However, arriving at that kind of solution requires more clinical research, targeting the implications of long-term treatment, adverse effects, and epigenetic implications.

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Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate

Cited by 27 publications

References 30 publications

New herbal composition (OA-F2) protects cartilage degeneration in a rat model of collagenase induced osteoarthritis

New herbal composition (OA-F2) protects cartilage degeneration in a rat model of collagenase induced osteoarthritis

Prospective Effect of Red Algae,actinotrichia Fragilis, Against Some Osteoarthritisaetiology

Unraveling Natural Products’ Role in Osteoarthritis Management—An Overview

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