Anti-osteoporosis Effect of 5-Bromo-2-(4-chlorobenzoyl)-(Z)-3-(2-cyano-3-hydroxybut-2-enonyl)aminobenzo[b]furan: a Novel Selective Estrogen Receptor Modulator

Fukuyama, Ryo; Shimokawa, Akio; Kodama, Yasushi; Fujita, Mitsugu; Ohishi, Yoshitaka; Ando, Yumiko; Koida, Masao; Nakamuta, Hiromichi

doi:10.1254/jphs.11049fp

Cited by 4 publications

(2 citation statements)

References 27 publications

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Section: Introductionmentioning

confidence: 99%

“…The chemical structure of MU314 was previously described [9,10]. Although research on the effects of MU314 on bone has been performed in the past, the research focused on actual conditions and the effects on the brain were hardly examined [7][8][9]. Our recent in vitro study using PC12 cells demonstrated that nerve growth factor (NGF)-induced neurite outgrowth was significantly potentiated by the addition of MU314, and that these effects were mediated by not only estrogen receptors, but also the MAPK pathway and Sigma-1 [10].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

MU314, a novel selective estrogen receptor modulator (SERM), improves estrogen-dependent depressive behaviors

Izumo¹,

Ishibashi²,

Ono³

et al. 2017

Glob Drugs Therap

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MU314, a novel selective estrogen receptor modulator (SERM), improves estrogen-dependent depressive behaviors

Izumo¹,

Ishibashi²,

Ono³

et al. 2017

Glob Drugs Therap

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Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model

Saito

Nakamura

Chinen

et al. 2020

Journal of Pharmacological Sciences

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In Vitro and In Vivo Effects of Xanthorrhizol on Human Breast Cancer MCF-7 Cells Treated With Tamoxifen

Noomhorm¹,

Chang²,

Wen³

et al. 2014

J Pharmacol Sci

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IntroductionBreast cancer is the most frequently diagnosed cancer among women internationally and is the second highest cause of cancer-related death. The incidence of breast cancer varies hugely around the world, both in developed and developing countries (1). In Thailand, breast cancer is currently the most common cancer and involves 43% of all cancers diagnosed in women (2).Estrogen receptors, when binding with estrogen, have important physiological roles in cardiovascular protection, the humoral immune response, neuroprotection, and bone remodeling. In breast cancer cells, estrogen and/or progesterone receptor status is highly linked to the patients' prognosis after surgery (3). Although many selective estrogen receptor modulators have been studied (4, 5), at present, hormonal therapy with tamoxifen is considered a gold standard when preventing tumor recurrence in women with hormone-responsive breast cancer. Tamoxifen, a non-steroidal selective estrogen receptor modulator, is commonly used for the hormone therapy of receptors-positive breast cancers in pre- Chang-Gung Memorial Hospital, Taoyuan, 333, Taiwan, ROC Received February 2, 2014; Accepted May 8, 2014 Abstract. This study investigated the herb-drug interaction of xanthorrhizol and tamoxifen in human breast cancer cells. Using MCF-7 cell line as an in vitro model, the herb-drug interaction between xanthorrhizol and tamoxifen was measured by MTT assay, luciferase reporter assay, and cell cycle analysis. The effects of xanthorrhizol on growth/autophagy related signaling were determined by immunostaining, western blotting, and real time RT-PCR. Additionally, the in vivo effect of xanthorrhizol and tamoxifen on athymic nude mice implanted with MCF-7 cells was evaluated. When MCF-7 cells were co-treated with tamoxifen and xanthorrhizol, there were no significant changes in terms of cell number, luciferase activity, percentage S-phase cells and LC3-II expression. However, using the MCF-7 implanted nude mice model, it was possible to detect significantly increased tumor volumes, a larger tumor size, and increased protein expression of P38 and P27(Kip1) in the xanthorrhizol + tamoxifen group compared to the tamoxifen-alone group. It can be concluded that while there is no significant herb-drug interaction between xanthorrhizol and tamoxifen in vitro, there is such an interaction in tumor-bearing mice, which provides important information that affects breast cancer treatment translational research. In Vitro and In Vivo Effects of Xanthorrhizol on Human Breast Cancer MCF-7 Cells Treated With Tamoxifen

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Anti-osteoporosis Effect of 5-Bromo-2-(4-chlorobenzoyl)-(Z)-3-(2-cyano-3-hydroxybut-2-enonyl)aminobenzo[b]furan: a Novel Selective Estrogen Receptor Modulator

Cited by 4 publications

References 27 publications

MU314, a novel selective estrogen receptor modulator (SERM), improves estrogen-dependent depressive behaviors

MU314, a novel selective estrogen receptor modulator (SERM), improves estrogen-dependent depressive behaviors

Effects of anti-osteoporosis drugs against dexamethasone-induced osteoporosis-like phenotype using a zebrafish scale-regeneration model

In Vitro and In Vivo Effects of Xanthorrhizol on Human Breast Cancer MCF-7 Cells Treated With Tamoxifen

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