Anti-oxidant potential of plants and probiotic spp. in alleviating oxidative stress induced by H2O2

Kumar, Harsh; Dhalaria, Rajni; Guleria, Shivani; Cimler, Richard; Sharma, Ruchi; Siddiqui, Shahida Anusha; Valko, Marián; Nepovimová, Eugenie; Dhanjal, Daljeet Singh; Singh, Reena; Kumar, Vijay; Pathera, Ashok Kumar; Verma, Narinder; Kaur, Talwinder; Manickam, Sivakumar; Alomar, Suliman Yousef; Kuča, Kamil

doi:10.1016/j.biopha.2023.115022

Cited by 26 publications

(4 citation statements)

References 149 publications

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“…As one of the most important oxidants, the level of reactive oxygen species (ROS) can indirectly reflect the degree of oxidation of the body’s cells, and its accumulation can cause oxidative damage to the body [ 32 ]. As shown in Figure 4 A, low, medium and high concentrations of Lpb.…”

Section: Resultsmentioning

confidence: 99%

Lactiplantibacillus plantarum A72, a Strain with Antioxidant Properties, Obtained through ARTP Mutagenesis, Affects Caenorhabditis elegans Anti-Aging

Zou,

Wu,

et al. 2024

Foods

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This research endeavored to elucidate the antioxidant attributes of lactic acid bacteria, specifically their impact on anti-aging and lifespan augmentation in Caenorhabditis elegans. The study focused on Lactiplantibacillus plantarum A72, identified through ARTP mutagenesis for its potent antioxidant properties. In vitro analysis affirmed its free radical neutralizing capacity. In C. elegans, the strain not only extended the lifespan by 25.13% and amplified motility 2.52-fold, but also maintained reproductive capabilities. Remarkably, Lpb. plantarum A72 diminished reactive oxygen species (ROS) and malondialdehyde (MDA) levels in C. elegans by 34.86% and 69.52%, respectively, while concurrently enhancing its antioxidant enzyme activities. The strain also bolstered C. elegans survival rates by 46.33% and 57.78% under high temperature and H2O2 conditions, respectively. Transcriptomic scrutiny revealed that Lpb. plantarum A72 could retard C. elegans aging and extend lifespan by upregulating the sod-5 and hsp-16.1 genes and downregulating the fat-6 and lips-17 genes. These findings propose Lpb. plantarum A72 as a potential antioxidant and anti-aging lactic acid bacteria.

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Section: Resultsmentioning

confidence: 99%

Lactiplantibacillus plantarum A72, a Strain with Antioxidant Properties, Obtained through ARTP Mutagenesis, Affects Caenorhabditis elegans Anti-Aging

Zou,

Wu,

et al. 2024

Foods

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“…It also creates the initial line of defense against oxidative damage, serves as the primary intracellular redox buffer, and is a cosubstrate in the GSH peroxidase-catalyzed reaction of H2O2 or lipid peroxidation that depletes it [76]. The oxidation of biological components, including DNA, proteins, and lipids, directly results from superoxides, hydroxyls, hydrogen peroxide, and other oxygen radicals among ROS [77], [78]. Under normal physiological circumstances, antioxidative enzymes and non-enzymatic molecules, including catalases, superoxide dismutase, glutathione peroxidase, tocopherol, glutathione, and ascorbic acid present in the cell control damages brought on by ROS [79].…”

Section: Possible Side Effects Of Copper Nanoparticlesmentioning

confidence: 99%

Development of copper nanoparticles and their prospective uses as antioxidants, antimicrobials, anticancer agents in the pharmaceutical sector

Tyagi

Arya

Mazumder

et al. 2023

Precision Nanomedicine

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In this study, we review the synthesis of copper nanoparticles (CuNPs) and their prospective uses as antioxidants, antimicrobials, and anticancer agents in the pharmaceutical sector. Copper nanoparticles could be created through a variety of methods, including chemical reduction, green synthesis, physical methods, electrochemical deposition, and the microemulsion method. These methods make it possible to precisely create nanoparticles with the necessary shapes, sizes, and surface properties, which in turn affect how well they perform biologically. CuNPs have strong antioxidant properties because they can scavenge reactive oxygen species (ROS) and prevent oxidative damage. In addition to their antioxidant properties, CuNPs show antibacterial activity against a number of microbes, including bacteria, fungi, and viruses. The potential of CuNPs as an anticancer agent has also been extensively investigated. These nanoparticles have toxic effects on a variety of cancer cell lines by inducing apoptosis, inhibiting cell proliferation, and preventing tumour angiogenesis. Because of their specific toxicity towards cancer cells while protecting normal cells, they provide the fascinating potential for tailored therapy to overcome multidrug resistance. CuNPs have also been studied in relation to their usage in medications. They may be utilised to improve drug delivery systems, wound healing, diagnostic imaging, immunotherapy, and anti-inflammatory and antioxidant effects. They can also be used to improve pharmaceutical stability, bioavailability, and provide controlled release. More research is needed to ensure their safety, enhance their synthesis processes, and explore their full potential in therapeutic situations

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“…Probiotic bacteria, such as Lactobacillus spp., have been well reported for their antioxidant potential [55]. We performed an assay of oxygen radical absorbance capacity (ORAC), a method that measures the fluorescent signal from a probe that is quenched in the presence of ROS to determine whether probiotic bacteria-derived EVs (LpEVs) exhibit antioxidant effects.…”

Section: Antioxidant Effect Of Lpevsmentioning

confidence: 99%

Human Probiotic Lactobacillus paracasei-Derived Extracellular Vesicles Improve Tumor Necrosis Factor-α-Induced Inflammatory Phenotypes in Human Skin

Lee,

Kim,

Lee

et al. 2023

Cells

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Lactic acid bacteria (LAB), a probiotic, provide various health benefits. We recently isolated a new Lactobacillus paracasei strain with strong anti-inflammatory effects under lipopolysaccharide-induced conditions and proposed a new mode of action—augmenting the endoplasmic reticulum stress pathway for anti-inflammatory functions in host cells. The beneficial effects of the L. paracasei strains on the skin have been described; however, the effects of L. paracasei-derived extracellular vesicles (LpEVs) on the skin are poorly understood. Herein, we investigated whether LpEVs can improve inflammation-mediated skin phenotypes by determining their effects on primary human skin cells and a three-dimensional (3D) full-thickness human skin equivalent under tumor necrosis factor (TNF)-α-challenged inflammatory conditions. LpEVs were efficiently taken up by the human skin cells and were much less cytotoxic to host cells than bacterial lysates. Furthermore, low LpEV concentrations efficiently restored TNF-α-induced cellular phenotypes, resulting in increased cell proliferation and collagen synthesis, but decreased inflammatory factor levels (matrix metalloproteinase 1, interleukin 6, and interleukin 8) in the human dermal fibroblasts, which was comparable to that of retinoic acid, a representative antiaging compound. The beneficial effects of LpEVs were validated in a 3D full-thickness human skin equivalent model. LpEV treatment remarkably restored the TNF-α-induced epidermal malformation, abnormal proliferation of keratinocytes in the basal layer, and reduction in dermal collagen synthesis. Additionally, LpEVs penetrated and reached the deepest dermal layer within 24 h when overlaid on top of a 3D full-thickness human skin equivalent. Furthermore, they possessed superior antioxidant capacity compared with the human cell-derived EVs. Taken together, the anti-inflammatory probiotic LpEVs can be attractive antiaging and antioxidant substances for improving inflammation-induced skin phenotypes and disorders.

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Anti-oxidant potential of plants and probiotic spp. in alleviating oxidative stress induced by H2O2

Cited by 26 publications

References 149 publications

Lactiplantibacillus plantarum A72, a Strain with Antioxidant Properties, Obtained through ARTP Mutagenesis, Affects Caenorhabditis elegans Anti-Aging

Lactiplantibacillus plantarum A72, a Strain with Antioxidant Properties, Obtained through ARTP Mutagenesis, Affects Caenorhabditis elegans Anti-Aging

Development of copper nanoparticles and their prospective uses as antioxidants, antimicrobials, anticancer agents in the pharmaceutical sector

Human Probiotic Lactobacillus paracasei-Derived Extracellular Vesicles Improve Tumor Necrosis Factor-α-Induced Inflammatory Phenotypes in Human Skin

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