Anti-oxidant, pro-oxidant properties of tannic acid and its binding to DNA

Khan, Nelofer; Ahmad, Aamir; Hadi, S. M.

doi:10.1016/s0009-2797(00)00143-5

Cited by 232 publications

(119 citation statements)

References 24 publications

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“…(24,25). According to unpublished data, NAC increased ROS levels in propyl gallate-treated CPAEC but decreased the level in MG132, a proteasome inhibitor-treated CPAEC.…”

Section: Discussionmentioning

confidence: 93%

Pyrogallol-induced endothelial cell death is related to GSH depletion rather than ROS level changes

Park¹

2009

Oncol Rep

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Abstract. Pyrogallol (PG) as a polyphenol compound induces apoptosis in several types of cells. Here, we evaluated the effects of PG on endothelial cells (ECs), especially calf pulmonary artery endothelial cells (CPAEC) in relation to the cell growth, ROS and glutathione (GSH) levels. PG dosedependently inhibited the growth of CPAEC and human umbilical vein endothelial cells (HUVEC) at 24 h. PG also induced apoptosis in CPAEC, which was accompanied by the loss of mitochondrial membrane potential (MMP; Δae m ). PG decreased ROS level including O 2•-and PG dose-dependently increased GSH depleted cell number in both EC types. Nacetyl-cysteine (NAC; a well-known antioxidant) increased ROS levels in PG-treated CPAEC with the prevention of cell death and GSH depletion. In conclusion, PG inhibited the growth of ECs, especially CPAEC via apoptosis. PG-induced EC death was related to GSH depletion rather than ROS level changes.

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“…(24,25). According to unpublished data, NAC increased ROS levels in propyl gallate-treated CPAEC but decreased the level in MG132, a proteasome inhibitor-treated CPAEC.…”

Section: Discussionmentioning

confidence: 93%

Pyrogallol-induced endothelial cell death is related to GSH depletion rather than ROS level changes

Park¹

2009

Oncol Rep

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“…In a recent study carried out in vitro, it was demonstrated that tannic acid had a free radical sweeping effect and that it increased antioxidant levels while reducing lipid peroxidation (Gulcin et al 2010). On the other hand, tannic acid was reported to have a pro-oxidant capacity by creating hydroxyl radical in the presence of copper (Khan et al 2000). A study reported that there were low SOD activity, high MDA concentration and low level of CAT activity in blood samples of hypertensive individuals compared to normotensive individuals.…”

Section: Discussionmentioning

confidence: 99%

Impact of tannic acid on blood pressure, oxidative stress and urinary parameters in L-NNA-induced hypertensive rats

et al. 2013

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Hypertension is a major health problem with increasing prevalence around the world. Tannic acid is water-soluble polyphenol that is present in tea, green tea, coffee, red wine, nuts, fruits and many plant foods. It has been reported to serve as an antioxidant or a pro-oxidant depending on the type of cells and its concentration. The purpose of our study was to evaluate the effect of tannic acid on systolic blood pressure, oxidative stress and some urinary parameters in the rat model of essential hypertension. Blood pressures of all rats were measured using the tail-cuff method. The nitric oxide synthase inhibitor N (omega)-nitro-L-arginine was administered orally at a dose of 0.5 g/l/day for 15 days to rats in order to create an animal model of hypertension. Tannic acid was intraperitoneally injected at a dose of 50 mg/kg for 15 days. Superoxide dismutase, catalase activity and the concentration of malondialdehyde (MDA) were determined in blood plasma and homogenates of heart, liver and kidney. In order to evaluate renal functions, urine pH, urine volume, urine creatine, uric acid, and urea nitrogen values were measured. Compared with the hypertension group, a decrease in MDA concentrations of heart tissue (p \ 0.01), urea nitrogen values (p \ 0.01) and urine volumes (p \ 0.001) were established in hypertension ? tannic acid group. There was also a decrease in blood pressure values (20th and 30th days) of this group, but there was no a statistical difference according to hypertension group. The findings of our research show the effect of tannic acid in lowering blood pressure in hypertensive rats.

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“…The antioxidant mechanism of tannic acid is still far from being fully understood; therefore, it requires further investigation. For example, in the presence of copper ions, tannic acid acts either as a prooxidant, promoting DNA damage (Ferguson, 2001;Khan et al, 2000), or as an antioxidant, suppressing hydroxyl radical formation (Andrade et al, 2005).…”

Section: Zoology Department College Ofmentioning

confidence: 99%