Anti-oxidative effects of 4-hydroxybenzyl alcohol in astrocytes confer protective effects in autocrine and paracrine manners

Luo, Lidan; Kim, Seung-Woo; Lee, Hye Kyung; Kim, Il‐Doo; Lee, Hahnbie; Lee, Ja-Kyeong

doi:10.1371/journal.pone.0177322

Cited by 25 publications

(20 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Modern pharmacological studies have shown that RGE extract has neuroprotective, antioxidant, anti-anxiety, anti-depressant, sedative, anti-inflammatory and anti-angiogenic effects [4,5,6,7,8,9,10]. Gastrodin (GAS) and p -hydroxybenzyl alcohol (HBA) have been considered to be the active ingredients for a long time, due to their significant pharmacological activities [11,12,13,14,15]. Therefore, they were listed as the quality evaluation indicators of RGE in the Chinese Pharmacopoeia all along.…”

Section: Introductionmentioning

confidence: 99%

Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume

Liu

et al. 2019

Molecules

View full text Add to dashboard Cite

To explore the transformation mechanisms of free gastrodin and combined gastrodin before and after steaming of Gastrodia elata (G. elata), a fresh G. elata sample was processed by the traditional steaming method prescribed by Chinese Pharmacopoeia (2015 version), and HPLC-ESI-TOF/MS method was used to identify the chemical composition in steamed and fresh G. elata. Finally, 25 components were identified in G. elata based on the characteristic fragments of the compounds and the changes of the 25 components of fresh and steamed G. elata were compared by the relative content. Hydrolysis experiments and enzymatic hydrolysis experiments of 10 monomer compounds simulating the G. elata steaming process were carried out for the first time. As a result, hydrolysis experiments proved that free gastrodin or p-hydroxybenzyl alcohol could be obtained by breaking ester bond or ether bond during the steaming process of G. elata. Enzymatic experiments showed that steaming played an important role in the protection of gastrodin, confirming the hypothesis that steaming can promote the conversion of chemical constituents of G. elata—inhibiting enzymatic degradation. This experiment clarified the scientific mechanism of the traditional steaming method of G. elata and provided reference for how to apply G. elata decoction to some extent.

show abstract

Section: Introductionmentioning

confidence: 99%

Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume

Liu

et al. 2019

Molecules

View full text Add to dashboard Cite

show abstract

“…4HYBZOH is a colourless liquid with a mild and pleasant scent with authorised used as food additive in restricted amounts by the "regulation (EU) No 872/2012 of 1 October 2012". It has been identified in small amounts in Arcangelisia gusanlung (a small shrub from China) and has little industrial use beyond the food industry, with specialty applications in the pharmaceutical (Luo et al, 2017) and materials (Tao et al, 2017) industries. Chlorinated benzyl alcohols have never, to the best of the author's knowledge, been reported to occur naturally, thus are exclusively anthropogenic.…”

Section: Benzyl Alcoholsmentioning

confidence: 99%

Development of new oil/water partitioning tracers for the determination of residual oil saturation in the inter-well region of water-flooded reservoirs

Silva¹

2021

View full text Add to dashboard Cite

is credited to have said "the value of achievement lies in the achieving." This is true for everything in life, and I feel very lucky and thankful for all the people I worked with in the path leading to this thesis. It is also their achievement, as it would not be possible without them. I learned and was trained by the best in the field, who also showed me that an open-mind, humility, and hard-work pave the way forward. I would like to thank my supervisors, Professor Tor Bjørnstad and Professor Svein Magne Skjaeveland. Thank you, Tor, for all the insights, trust, freedom, patience, and advice! You truly are a role model, and I will be happy if I become half of what you are, both as a researcher and as a person. I could not have done this without you! Thank you Svein for all the kind and motivating words, for the example, and for the rigor with flexibility. This would not happen without you! I want to thank the team of the "Tracer Technology department" at IFE, particularly Sissel Opsahl Viig for sharing her knowledge, time, patience, and good humour, as well as for the help in disassembling and assembling instrumentation! Per Arne Hubred, one of the best humoured and cleverest engineers I ever met, who made the "magic happen" whenever experimental needs would hit a wall. Are Haugen, for all the trouble and help in welcoming me to a new workplace and a new country. Laura Ferrando-Climent, for all the small talk in coffee breaks, confidences, incentive, the friendship, and the sharing of insights about good scientific work. A special thank you to Helge Stray, my office colleague, "informal supervisor", for all the fruitful discussions and exchange of ideas, reviews, motivation, friendship, and help with personal and logistic issues upon my arrival in Norway. I would also like to thank the National IOR Centre of Norway for employing me and all its fantastic members, past and present colleagues at UiS, IFE and NORSE, especially Mahmoud Ould Metidji for the fantastic comradeship, friendship, and collaboration, Thomas Brichart vi for introducing me to the "nano-world" and for the comradeship, Jaspreet Singh Sachdeva for the optimism, motivation, and the insights about pore-scale phenomena, Eystein Opsahl for the warmth, good humour, good discussions, and excellent collaboration. Additionally, I want to thank Aksel Hiorth, Jan Ludvig Vinningland, Merete Madla Vadland, Randi Valestrand, for all the gatherings, discussions, and insights always with lots of fun! Many more are left out, each with valuable contributions. Working with the National IOR Centre of Norway was an exciting and challenging experience, filled with excellent scientific discussions, exchange of ideas and fun, without forgetting our industry partners and their valuable input. Finally, my biggest thank you to my family! To Sofia, for the strength and constant support throughout all the challenges I faced even while facing her own! None of my achievements would be possible without you as my partner and inspiration! To Maria João and Francisca, for being t...

show abstract

“…In addition, it can upregulate and can activate Nrf2 and consequently stimulate the expression of some antioxidative enzymes including HO‐1, NAD(P)H quinone dehydrogenase 1 (NQO1), and GCLM. Other signaling pathways such as extracellular signal‐regulated kinase (ERK) and Akt also were activated by gastrodigenin (Luo et al, ).…”

Section: Neurotoxicitymentioning

confidence: 99%

The neuroprotective activities of natural products through the Nrf2 upregulation

Tavakkoli

Iranshahi

Hasheminezhad

et al. 2019

Phytotherapy Research

View full text Add to dashboard Cite

Nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) is a basic‐region leucine zipper transcription factor that regulates the expression of many Phase II detoxifying/antioxidant enzymes. Many natural products act on the Nrf2 pathway and exhibit their preventive and/or therapeutic effects by activating Nrf2 and subsequently antioxidant enzymes. In this article, we reviewed the research literature that described Nrf2 activation as a mechanism for the neuroprotective effect of natural products. Our results showed that the inhibition of Kelch‐like ECH‐associated protein 1 and the activation of different intracellular kinases that lead to Nrf2 phosphorylation were the main mechanisms of Nrf2 upregulation suggested for these the natural products. Although some natural compounds such as terpenoids and alkaloids were reported to protect the nervous system by Nrf2 activating, flavonoids and phenolic compounds represent the majority of the reported neuroprotective natural substances that activate Nrf2. We also evaluated the physiochemical properties of some of the same substances to predict their oral bioavailability and central nervous system penetration. The results showed that sulforaphane and berberine have good oral bioavailability and would be predicted to cross through blood–brain barrier (BBB) easily, whereas the flavonoids in general would be predicted to be less effective in BBB transition because of their relatively high polar surface area.

show abstract

Anti-oxidative effects of 4-hydroxybenzyl alcohol in astrocytes confer protective effects in autocrine and paracrine manners

Cited by 25 publications

References 40 publications

Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume

Transformation Mechanisms of Chemical Ingredients in Steaming Process of Gastrodia elata Blume

Development of new oil/water partitioning tracers for the determination of residual oil saturation in the inter-well region of water-flooded reservoirs

The neuroprotective activities of natural products through the Nrf2 upregulation

Contact Info

Product

Resources

About