Anti–oxidative role of quercetin derived from Allium cepa on aldehyde oxidase (OX–LDL) and hepatocytes apoptosis in streptozotocin–induced diabetic rat

Bakhshaeshi,, None Mina; Khaki, Arash; Fathiazad, Fatemeh; Khaki, Amir Afshin; Ghadamkheir, Elham

doi:10.1016/s2221-1691(12)60090-2

Cited by 30 publications

(14 citation statements)

References 20 publications

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“…The dietary flavonoid quercetin is thought to promote health, partly due to its ability to act as an antioxidant against ROS (Hertog and Hollman, ; Ramos‐Romero et al ., ) and to inhibit xanthine oxidase (XO; Zhu et al ., ). This compound decreases oxidative stress, improves the antioxidant status and inhibits liver cell apoptosis in STZ‐induced type 1 diabetic rats (Dias et al ., ; Babujanarthanam et al ., ; Bakhshaeshi et al ., ). It also alleviates hepatic fat accumulation in C57/BL6J mice fed a Western‐style diet (Kobori et al ., ).…”

Section: Introductionmentioning

confidence: 97%

Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

Wang

Ding

et al. 2013

British J Pharmacology

169

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Background and Purpose Thioredoxin‐interacting protein (TXNIP), a regulator of cellular oxidative stress, has been associated with activation of NOD‐like receptor 3 (NLRP3) inflammasome, inflammation and lipid metabolism, suggesting it has a role in the pathogenesis of non‐alcoholic fatty liver disease (NAFLD) in diabetes. In this study we investigated whether TXNIP is involved in type 1 diabetes‐associated NAFLD and whether antioxidants, quercetin and allopurinol, alleviate NAFLD by targeting TXNIP. Experimental Approach Diabetes was induced in male Sprague‐Dawley rats by a single i.p. injection of 55 mg·kg−1 streptozotocin. Quercetin and allopurinol were given p.o. to diabetic rats for 7 weeks. Hepatic function, oxidative stress, inflammation and lipid levels were determined. Rat BRL‐3A and human HepG2 cells were exposed to high glucose (30 mM) in the presence and absence of antioxidants, TXNIP siRNA transfection or caspase‐1 inhibitor, Ac‐YVAD‐CMK. Key Results Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down‐regulation of PPARα and up‐regulation of sterol regulatory element binding protein‐1c (SREBP‐1c), SREBP‐2, fatty acid synthase and liver X receptor α, as well as elevation of ROS and IL‐1β in diabetic rat liver. These effects were confirmed in hepatocytes in vitro and it was further shown that TXNIP down‐regulation contributed to the suppression of NLRP3 inflammasome activation, inflammation and changes in PPARα and SREBPs. Conclusions and Implications Inhibition of hepatic TXNIP by quercetin and allopurinol contributes to the reduction in liver inflammation and lipid accumulation under hyperglycaemic conditions. The targeting of hepatic TXNIP by quercetin and allopurinol may have therapeutic implications for prevention of type 1 diabetes‐associated NAFLD.

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Section: Introductionmentioning

confidence: 97%

Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

Wang

Ding

et al. 2013

British J Pharmacology

169

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“…The number of individuals affected by DM is increasing all over the world because of physical inactivity, increased prevalence of obesity, urbanization and population aging. Hyperglycemia is associated with the production of reactive oxygen species (ROS) and with the lowering of antioxidant capacity, which play an important role in the oxidative damage especially in the liver, kidneys, eyes, nerves, pancreas and blood vessels (2,5,7,24,37).…”

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confidence: 99%

Protective effects of Quercetin and chronic moderate exercise (training) against oxidative stress in the liver tissue of streptozotocin-induced diabetic rats

Chiş

Muresan

Oros

et al. 2016

Acta Physiologica Hungarica

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Background: To investigate the protective effects of Quercetin administration associated with chronic moderate exercise (training) on oxidative stress in the liver in streptozotocin-induced diabetic rats. Methods: Diabetic rats that performed exercise training were subjected to a swimming training program (1 hour/day, 5 days/week, 4 weeks). The diabetic rats received natural antioxidant, Quercetin (20 mg/kg body weight/day) for 4 weeks. At the end of the study, all animals were sacrificed and liver samples were collected for estimation: some oxidative stress markers (malondialdehyde, MDA and protein carbonyls groups, PC), the activity of antioxidant enzymes (superoxide dismutase, SOD and catalase, CAT), reduced glutathione (GSH) level and reduced (GSH) and oxidized (GSSG) glutathione ratio. Results: Diabetic rats submitted to exercise training showed significantly increased the oxidative stress markers (MDA and PC) and a reduction of antioxidant enzyme (SOD and CAT) activity, GSH level and GSH/ GSSG ratio in hepatic tissues. A decrease in the levels of oxidative stress markers associated with elevated activity of antioxidant enzymes, the GSH level and GSH/GSSG ratio in the hepatic tissue were observed in Quercetin-treated diabetic trained rats. Conclusions: These findings suggest that Quercetin administration in association with chronic moderate exercise exerts a protective effect in diabetes by attenuating hyperglycemia-mediated oxidative stress in hepatic tissue.

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“…Ansar et al showed that QCT protected the liver against DNA damage induced by acrylamide (29). The QCT inhibits apoptosis in alcohol-induced liver toxicity (30), prevents apoptosis in hepatocytes of diabetic rats (31), and suppresses the apoptosis in mesangial cells of kidney exposed to H 2 O 2 (32). Anti-apoptotic impacts of QCT against traumatic brain injury were also reported by Yang et al (33).…”

Section: Discussionmentioning

confidence: 83%

Quercetin Effects on Hepatotoxicity Induced by Titanium Dioxide Nanoparticles in Rats

Shirani

Khorsandi

Alidadi

2019

Jundishapur J Nat Pharm Prod

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Background: Most nanoparticles have adverse impacts on the liver, which is a vital body organ, by the induction of oxidative stress. Objectives: This study was designed to evaluate the hepatoprotective effects of quercetin (QCT) against the toxicity of nanoscale titanium dioxide (NTiO2) in Wistar rats. Methods: The present study was conducted on 32 adult female Wistar rats assigned into 4 groups of control, NTiO2 (50 mg/kg), NTiO2 + Quercetin (50 + 75 mg/kg), and Quercetin (75 mg/kg). The animals exposed to NTiO2 were administered by 50 mg/kg of NTiO2 for 21 days. The Quercetin + NTiO2 rats received Quercetin before exposing to NTiO2 for 7 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) of serum were considered indicators of the hepatotoxicity. The oxidative stress was assessed by measuring the activity of catalase (CAT) and superoxide dismutase (SOD) as well as the level of malondialdehyde (MDA) in the liver. TUNEL assay and histological changes were also assessed. Results: The NTiO2 significantly elevated the MDA level (P < 0.01), enhanced the serum biomarker levels, reduced the CAT (P < 0.01) and SOD (P < 0.01) activities. The NTiO2 also aggregated the red blood cells, and caused inflammatory cell infiltration, nuclear pyknosis and fat deposit in hepatocytes, as well as induced apoptosis in the liver tissue. Pretreatment with QCT quenched oxidative stress, attenuated the histological changes, elevated the CAT (P < 0.01) and SOD (P < 0.01) activities, normalized the serum biomarker levels and decreased apoptosis (P < 0.001). Conclusions: The QCT has an inhibitory impact on hepatotoxicity induced by nanoparticles in rats.

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Anti–oxidative role of quercetin derived from Allium cepa on aldehyde oxidase (OX–LDL) and hepatocytes apoptosis in streptozotocin–induced diabetic rat

Cited by 30 publications

References 20 publications

Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

Quercetin and allopurinol reduce liver thioredoxin‐interacting protein to alleviate inflammation and lipid accumulation in diabetic rats

Protective effects of Quercetin and chronic moderate exercise (training) against oxidative stress in the liver tissue of streptozotocin-induced diabetic rats

Quercetin Effects on Hepatotoxicity Induced by Titanium Dioxide Nanoparticles in Rats

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