Anti-oxLDL antibodies are clinically insignificant for stroke patients

Masztalewicz, Marta; Nowacki, Przemysław; Kotlęga, Dariusz; Bajer-Czajkowska, Anna; Drechsler, Hanna

doi:10.1179/1743132813y.0000000268

Cited by 10 publications

(8 citation statements)

References 21 publications

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“…However, the findings of different studies about the importance of oxLDL antibodies in association or prediction of atherosclerosis are inconsistent and inconclusive. The increased levels of anti‐oxLDL antibodies were predictive of mortality, myocardial infarction occurrence and carotid atherosclerosis progression . The autoantibodies directed against oxLDL are likely belong to two separate families of antibodies .…”

Section: Therapeutic Approachesmentioning

confidence: 99%

“…The increased levels of anti-oxLDL antibodies were predictive of mortality, myocardial infarction occurrence and carotid atherosclerosis progression. 74 The autoantibodies directed against oxLDL are likely belong to two separate families of antibodies. 75 On one side, 'pathogenic' antibodies increase atherosclerosis progression and significantly correlate with atherosclerotic plaque formation.…”

Section: Vaccination Against Atherosclerosis?mentioning

confidence: 99%

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Atherosclerosis and autoimmunity: a growing relationship

et al. 2018

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Atherosclerosis is regarded as one of the leading causes of mortality and morbidity in the world. Nowadays, it seems that atherosclerosis cannot be defined merely through the Framingham traditional risk factors and that autoimmunity settings exert a remarkable role in its mechanobiology. Individuals with autoimmune disorders show enhanced occurrence of cardiovascular complications and subclinical atherosclerosis. The mechanisms underlying the atherosclerosis in disorders like rheumatoid arthritis, systemic lupus erythematosus, antiphospholipid syndrome, systemic sclerosis and Sjögren's syndrome, seem to be the classical risk factors. However, chronic inflammatory processes and abnormal immune function may also be involved in atherosclerosis development. Autoantigens, autoantibodies, infectious agents and pro-inflammatory mediators exert a role in that process. Being armed with the mechanisms underlying autoimmunity in the etiopathogenesis of atherosclerosis in rheumatic autoimmune disorders and the shared etiologic pathway may result in substantial developing therapeutics for these patients.

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Section: Therapeutic Approachesmentioning

confidence: 99%

Section: Vaccination Against Atherosclerosis?mentioning

confidence: 99%

Atherosclerosis and autoimmunity: a growing relationship

et al. 2018

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“…In rheumatoid arthritis, IgG oxLDL‐ab levels have been demonstrated significantly higher compared with healthy controls, being strongly related to inflammation degree and the risk for atherosclerosis . Other studies have demonstrated the local production of IgG oxLDL‐ab levels in patients with aggressive periodontitis, the increased concentration in patients with atherogenic ischemic stroke, and the association with atherogenic indexes in HIV‐infected patients …”

Section: Discussionmentioning

confidence: 94%

“…28 In rheumatoid arthritis, IgG oxLDL-ab levels have been demonstrated significantly higher compared with healthy controls, 29,30 being strongly related to inflammation degree and the risk for atherosclerosis. 31 Other studies have demonstrated the local production of IgG oxLDL-ab levels in patients with aggressive periodontitis, 32 the increased concentration in patients with atherogenic ischemic stroke, 33 and the association with atherogenic indexes in HIV-infected patients. 34 Oxidized low-density lipoprotein antibodies/high-density lipoprotein cholesterol ratio was the best oxLDL-ab-based lipid index regarding all histological features, being strongly associated with NASH in lean patients.…”

Section: Discussionmentioning

confidence: 97%

Oxidized low‐density lipoprotein antibodies/high‐density lipoprotein cholesterol ratio is linked to advanced non‐alcoholic fatty liver disease lean patients

Ampuero

Ranchal

Gallego‐Durán

et al. 2016

J of Gastro and Hepatol

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“…The blood level of assessed antibodies was significantly higher in stroke patients than in control group. However, this phenomenon does not seem to protect patients against cerebrovascular events [34]. Recently a report found that a quiescent population of IgM+ plasma cells including oxLDL-specific IgM antibody secreting cells in bone marrow also sustained the elevated IgM antibody response in circulation [35].…”

Section: Discussionmentioning

confidence: 99%

The association between oxidized low-density lipoprotein antibodies and hematological diseases

et al. 2016

Lipids Health Dis

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BackgroundThe aim of the study is to compare the profiles of antibodies (IgM and IgG) against oxidized low-density lipoprotein (oxLDL) of hematological diseases.MethodsThe serum antibodies of oxLDL-IgM and oxLDL-IgG for 446 cases with hematological diseases and 90 patients with primary hypertension and 90 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA) in a cross-section survey. The association of serum oxLDL-LgM and oxLDL-IgG with hematological diseases was analyzed by multiple linear regression model.ResultsComparing with the hypertension or normal groups, the levels of TCH, TG, LDL-c, HDL-c, oxLDL, and oxLDL-IgG were lower and the levels of ADP and oxLDL-IgM were higher in the hematological diseases group. The levels of oxLDL-IgG antibodies titer were different among hematological diseases group. The results of correlation and multiple regression analysis showed that the seven hematological disease subgroups were positively related to the oxLDL-IgM antibody titer but negatively related to the oxLDL-IgG antibody titer, having been adjusted for potential confounding factors such as age, SBP, DBP, BMI, TCH, TG, ADP, oxLDL, HDL-c, LDL-C.ConclusionsHere we show that oxLDL-IgG antibodies titer were lower and of oxLDL-IgM titer were higher than hypertension and healthy individuals. Also oxLDL-IgG titer were different among hematological diseases group.

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Anti-oxLDL antibodies are clinically insignificant for stroke patients

Abstract: Patients with atherogenic ischemic stroke may have significantly higher anti-oxLDL Abs concentrations. This should be interpreted as an attempt to limit the consequences of oxLDL production; however, this phenomenon does not seem to protect patients against cerebrovascular events.

Cited by 10 publications

References 21 publications

Atherosclerosis and autoimmunity: a growing relationship

Atherosclerosis and autoimmunity: a growing relationship

Oxidized low‐density lipoprotein antibodies/high‐density lipoprotein cholesterol ratio is linked to advanced non‐alcoholic fatty liver disease lean patients

The association between oxidized low-density lipoprotein antibodies and hematological diseases

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