Anti-parasitic activity of Annona muricata L. leaf ethanolic extract and its fractions against Toxoplasma gondii in vitro and in vivo

Miranda, Natália Carnevalli; Araújo, Ester Cristina Borges; Justino, Allisson Benatti; Cariaco, Yusmaris; Mota, Caroline Martins; Costa-Nascimento, Layane Alencar; Espíndola, Foued Salmen; Silva, Neide Maria

doi:10.1016/j.jep.2021.114019

Cited by 15 publications

(12 citation statements)

References 44 publications

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“…In A. muricata extracts, Coria-Téllez et al [ 70 ] found 212 bioactive chemicals. Traditional medicine uses different plant parts to cure a range of diseases and ailments, including inflammation [ 77 ], rheumatism, diabetes [ 42 ], hypertension [ 107 ], and parasite infestation [ 82 ]. The fruit is often used to treat arthritis and fever, whereas the seed is used to treat worms.…”

Section: Ethnomedicinal Usesmentioning

confidence: 99%

A Review on Annona muricata and Its Anticancer Activity

Ilango

Sahoo

Paital

et al. 2022

Cancers

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The ongoing rise in the number of cancer cases raises concerns regarding the efficacy of the various treatment methods that are currently available. Consequently, patients are looking for alternatives to traditional cancer treatments such as surgery, chemotherapy, and radiotherapy as a replacement. Medicinal plants are universally acknowledged as the cornerstone of preventative medicine and therapeutic practices. Annona muricata is a member of the family Annonaceae and is familiar for its medicinal properties. A. muricata has been identified to have promising compounds that could potentially be utilized for the treatment of cancer. The most prevalent phytochemical components identified and isolated from this plant are alkaloids, phenols, and acetogenins. This review focuses on the role of A. muricata extract against various types of cancer, modulation of cellular proliferation and necrosis, and bioactive metabolites responsible for various pharmacological activities along with their ethnomedicinal uses. Additionally, this review highlights the molecular mechanism of the role of A. muricata extract in downregulating anti-apoptotic and several genes involved in the pro-cancer metabolic pathways and decreasing the expression of proteins involved in cell invasion and metastasis while upregulating proapoptotic genes and genes involved in the destruction of cancer cells. Therefore, the active phytochemicals identified in A. muricata have the potential to be employed as a promising anti-cancer agent.

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Section: Ethnomedicinal Usesmentioning

confidence: 99%

A Review on Annona muricata and Its Anticancer Activity

Ilango

Sahoo

Paital

et al. 2022

Cancers

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“…The activity of the essential oil is related to the quality of the active molecules present in it. The presence of active agents in the plant essential oil was determined in the previous studies [ 37 , 38 ]. Kariminik et al [ 16 ] found that D. polychaetum essential oil contains methyl cyclogeranate, limonene, linalool, sabinene, and p-menth-1-en-9-ol.…”

Section: Discussionmentioning

confidence: 99%

Anti-Toxoplasma Effects of Dracocephalum Polychaetum Essential Oil

Khamesipour

Pourmohammad

Jafarian-Dehkordi

2022

Interdisciplinary Perspectives on Infectious Diseases

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Background. Toxoplasma gondii is a common parasitic disease with a cosmopolitan prevalence, causing severe health problems. Although chemotherapy for toxoplasmosis is readily available, most have side effects. Objectives. This study assesses the Dracocephalum polychaetum essential oil against T. gondii activity. In vitro, the anti-Toxoplasma effects of D. polychaetum essential oils with different concentrations were evaluated. Methods. In the present study, T. gondii RH strain tachyzoites were exposed to D. polychaetum essential oil, and their viability effect on the parasite was evaluated. The viability test of tachyzoites was performed by using the staining method trypan blue in vitro. The inhibitory effect of D. polychaetum extract on T. gondii RH strain tachyzoites in the Vero cell line was evaluated. Results. D. polychaetum has valuable efficacy in vitro, outperforming pyrimethamine and sulfadiazine at 30 and 90 minutes after exposure ( p < 0.05 ). D. polychaetum essential oil showed anti-Toxoplasma activity in the cell line (IC50: 241.7 μg/mL). After T. gondii-infected Vero cells had been incubated with different concentrations of the D. polychaetum essential oil, their viability decreased in a dose-dependent manner. Conclusions. In conclusion, D. polychaetum extract as an herbal medicine might be a valuable alternative to routine chemotherapy for toxoplasmosis.

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“…Oral infection with T. gondii can cause immunopathology in a large number of animal species in addition to mice ( Schreiner and Liesenfeld, 2009 ); specifically, C57BL/6 mice develop intestinal, lung and liver pathology when infected orally with the parasite ( Oliveira et al., 2020 ; Miranda et al., 2021 ). In the present work, it was verified that Ext Ts -treatment decreased the liver and intestinal pathology.…”

Section: Discussionmentioning

confidence: 99%