Anti‐Parasitic Activity of Essential Oils and their Active Constituents against Plasmodium, Trypanosoma and Leishmania

Béro, Joanne; Kpoviessi, Salomé; Quetin-Leclercq, Joëlle

doi:10.1002/9781118460566.ch33

Cited by 18 publications

(21 citation statements)

References 58 publications

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“…β-caryophyllene (8.04 ± 0.03%), the fourth compound of this oil, showed moderate activity (IC 50 = 13.76 g/ml), while caryophyllene oxide (2.20%; IC 50 = 17.67 g/ml), α-cedrene (1.01%; IC 50 = 4.06 g/ml) and limonene (0.13%; IC 50 = 4.24 g/ml) were more effective. (E)-nerolidol (2.38 %) showed an interesting activity with an IC 50 value of 1.70 g/ml (Bero et al, 2014) similar to that (IC 50 =1.16 g/ml) obtained from the oil. Furthermore, Figure 1.…”

Section: Correlation Of Activity and Chemical Composition Of Essentiasupporting

confidence: 64%

“…The essential oil of Sb contains active compounds as myrcene (IC 50 = 2.24 g/ml), limonene (IC 50 = 4.24 g/ml), α-pinene (IC 50 = 4.09 g/ml), while sabinene (IC 50 = 17.67 g/ml), aromadendrene (IC 50 = 18.77 g/ml), βcaryophyllene (IC 50 = 13.76 g/ml) and caryophyllene oxide (IC 50 = 17.67 g/ml) had moderate activity. Other compounds as β-pinene (IC 50 = 47.37 g/ml), p-cymene (IC 50 = 76.32 g/ml), linalool (IC 50 = 39.26 g/ml) and thymol (IC 50 = 22.83 g/ml) had low activities (Bero et al, 2014). All these compounds do not explain the interesting activity (IC 50 = 0.46 g/ml) of this essential oil.…”

Section: Correlation Of Activity and Chemical Composition Of Essentiamentioning

confidence: 79%

“…and L. M. Perry Cheel and Kunzea ericoides (A. Rich) Joy Thomps, showed anti-trypanosomal activities, respectively with IC 50 values of 16.90, 0.50, 1.90 and 13.60 µg/ml (Bero et al, 2014). It was also reported that the ethanolic extract of Pg leaf was able to produce alterations in the biochemical parameters in the kidney and liver of rats experimentally infected with T. brucei brucei (Adeyemi and Akanji, 2011).…”

Section: Samplementioning

confidence: 93%

“…These oils show an interesting anti-trypanosomal activity, the most interesting being Pg (IC 50 = 1.16 ± 0.16 g/ml) and Sb (IC 50 = 0.46 ± 0.28 g/ml). According to Bero et al (2014), Ec oil has a moderate antitrypanosomal activity (2 ≤ IC 50 ≤ 20 g/ml). While the other oils exhibited good activities (IC 50 ≤ 2 g/ml) and could be of interest for future development (Bero et al, 2014).…”

Section: Anti-trypanosomal Anti-plasmodial Activities and Cytotoxicitymentioning

confidence: 99%

“…According to Bero et al (2014), Ec oil has a moderate antitrypanosomal activity (2 ≤ IC 50 ≤ 20 g/ml). While the other oils exhibited good activities (IC 50 ≤ 2 g/ml) and could be of interest for future development (Bero et al, 2014). The activity of Sb oil was not significantly different (P value = 0.1628> 0.1) than that of suramin (IC 50 = 0.11 ± 0.02 µg/ml), the standard compound used against this parasite.…”

Section: Anti-trypanosomal Anti-plasmodial Activities and Cytotoxicitymentioning

confidence: 99%

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Chemical composition, in vitro antioxidant and antiparasitic properties of the essential oils of three plants used in traditional medicine in Benin.

Kpadonou¹,

Kpoviessi²,

Béro³

et al. 2019

J. Med. Plants Res.

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Sclerocarya birrea (Sb), Psidium guajava (Pg) and Eucalyptus camaldulensis (Ec) are widely used in traditional medicine for the treatment of many diseases, some of which were related to oxidative stress and parasitic diseases. Their essential oils (EO) were analyzed by GC/MS and FID and tested in vitro for their antioxidant activities (DPPH), their anti-trypanosomal and anti-plasmodial activities against Trypanosoma brucei brucei (Tbb) (strain 427) and Plasmodium falciparum (Pf) (strain 3D7), respectively. Cytotoxicity was evaluated in vitro against CHO and WI38 cells (MTT) to evaluate the selectivity. They were shown to possess low antioxidant but a strong anti-trypanosomal and a good antiplasmodial activity with a good selectivity, except Ec oil whose anti-plasmodial activity was less interesting. Sb oil was the most active against Tbb(IC 50 = 0.46 ± 0.28 µg/ml) and Pf (5.21 ± 1.12 µg/ml). All tested oils had low or no cytotoxicity against CHO and WI38 cells. GC/MS and GC/FID analysis revealed that composition of Sb (49 compounds) was characterised by the presence as main constituents of 7-epi-αselinene, α-muurolene and valencene; Pg (60 compounds) by β-bisabolene, ar-curcumene and βbisabolol; Ec (43 compounds) by γ-terpinene and p-cymene. The activity of these oils seems to be the result of a synergistic action of all their constituents, including minor ones. This study shows that essential oils of Sb and Pg can be good sources of anti-trypanosomal and anti-plasmodial agents.

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Section: Correlation Of Activity and Chemical Composition Of Essentiasupporting

confidence: 64%

Section: Correlation Of Activity and Chemical Composition Of Essentiamentioning

confidence: 79%

Section: Samplementioning

confidence: 93%

Section: Anti-trypanosomal Anti-plasmodial Activities and Cytotoxicitymentioning

confidence: 99%

Section: Anti-trypanosomal Anti-plasmodial Activities and Cytotoxicitymentioning

confidence: 99%

See 3 more Smart Citations

Chemical composition, in vitro antioxidant and antiparasitic properties of the essential oils of three plants used in traditional medicine in Benin.

Kpadonou¹,

Kpoviessi²,

Béro³

et al. 2019

J. Med. Plants Res.

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Cholecalciferol combined with Satureja rechingeri essential oils improves growth performance and immune response of broiler chickens

Taghizadeh,

Esmaeili,

Vakili

2024

Veterinary Medicine & Sci

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BackgroundVitamin D possesses an important role in the maintenance and health of broiler chickens. Herbal essential oils (EOs) have been proposed as a suitable alternative to chemical drugs in intensive production management systems for better performance of broilers with slight side effects and admirable therapeutic properties.ObjectivesThis experiment was conducted to investigate the effects of feeding cholecalciferol (VD) in combination of Satureja rechingeri EO (SREO) on growth performance, haematological indicators and immunological response of broilers.MethodsA total of 540 1‐day‐old mixed‐sex broiler chickens (Ross 308) were used in a completely randomized design with a 3 × 3 factorial arrangement of treatments. Experimental treatments included different concentrations of cholecalciferol (VD) (0, 2000 and 4000 IU/kg = 0, 0.05 and 0.1 mg/kg) and SREO (0, 200 and 400 mg/kg) on growth performance, haematological indicators and immunological responses of broiler chickens were investigated.ResultsThe results showed that the chicken fed diet supplemented with 0.1 mg/kg VD (VD0.1) in combination of 200 mg/kg SREO (SREO200) increased the feed intake during the overall and first 14‐day periods of the trial when compared with other dietary treatments. Interaction of VD0.1 × SREO200 led to more body weight gain (BWG) in the grower and finisher phases than all other feed treatment groups. The blood level of lymphocyte at day 42, heterophil at days 28 and 42 and heterophil/lymphocyte (H/L) ratio at 14 and 28 days of age were affected by VD0.1 + SREO200 in comparison with VD0 + SREO0 group. Feeding VD and/or SREO decreased triglyceride, cholesterol and low‐density lipoprotein concentrations at days 28 and 42 of the study, especially in VD0.1 + SREO200 treatment. Feeding VD0.1 + SREO200 also resulted in higher serum status of immunoglobulin M, lysozymes and phagocytic percentage among all treatments.ConclusionConsidering the outcomes, it is suggested that the combination of suitable concentration of VD and EO of the plant had favourable effects on the immune system and performance criteria of broiler chickens.

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Essential Oil as a Source of Bioactive Compounds for the Pharmaceutical Industry

Dias,

Davis,

do Nascimento Remígio

et al. 2023

Drug Discovery and Design Using Natural Products

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Anti‐Parasitic Activity of Essential Oils and their Active Constituents against Plasmodium, Trypanosoma and Leishmania

Cited by 18 publications

References 58 publications

Chemical composition, in vitro antioxidant and antiparasitic properties of the essential oils of three plants used in traditional medicine in Benin.

Chemical composition, in vitro antioxidant and antiparasitic properties of the essential oils of three plants used in traditional medicine in Benin.

Cholecalciferol combined with Satureja rechingeri essential oils improves growth performance and immune response of broiler chickens

Essential Oil as a Source of Bioactive Compounds for the Pharmaceutical Industry

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