Anti-Parkinson’s Activity of Uncaria Rhynchophylla Extract on Rotenone Induced Parkinsonism Model in Male Albino Rats

Abstract

Present study investigated the curative effects of Uncaria rhynchophylla aqueous extract (URE) on v) S.c for 20 days. Group V, received S.c injection of rotenone (1.5 mg/kg/ 48h) in DMSO/saline 20% (w/v) interval for 20 days and gavaged URE 500 mg/kg daily for the left 15 days. Brain homogenate dopamine (DA), tyrosine hydroxylase (TH), tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-6 (IL-6), Total oxidant status (TOS), nitric oxide (NO) and total antioxidant capacity (TAC) were estimated. URE exerts anti-Parkinson's activity via increasing DA, TH, and TAC as well as reducing TNF-α, IL1-β, IL-6, TOS and NO. URE possesses neurotherapeutic properties against Parkinson's disease.