Anti-phospholipid antibodies in patients with multiple sclerosis and MS-like                 illnesses: MS or APS?

IJdo, Jacob W.; Conti-Kelly, AM; Greco, Paolo; Abedi, Mohammad Reza; Amos, Michael D.; Provenzale, James M.; Greco, Thomas

doi:10.1191/096120399678847461

Cited by 83 publications

(45 citation statements)

References 34 publications

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“…[5][6][7] There have been some case reports or series linking anticardiolipin antibodies (aCL Ab) and MS, optic neuritis, or trans-verse myelopathy. [8][9][10][11][12][13][14][15] Neuroradiological studies have shown an association between high intensity white matter lesions and the presence of aCL Ab, and some authors have suggested that aCL Ab are implicated in the pathogenesis of MS. However, others did not confirm that patients with MS and antiphospholipid antibodies constitute a subgroup of patients, which suggests that aCL Ab may be a non-specific marker of central nervous system injury.…”

mentioning

confidence: 99%

Anticardiolipin antibodies in patients with multiple sclerosis do not represent a subgroup of patients according to clinical, familial, and biological characteristics

Heinzlef

Weill²,

Johanet³

et al. 2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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mentioning

confidence: 99%

Anticardiolipin antibodies in patients with multiple sclerosis do not represent a subgroup of patients according to clinical, familial, and biological characteristics

Heinzlef

Weill²,

Johanet³

et al. 2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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“…Involvement of the CNS is often reported in patients with primary antiphospholipid antibody syndrome (APLAS)14; focal infarcts are the commonest MRI abnormalities described in this disease, although brain atrophy and diffuse white matter hyperintense lesions can also be found in a high percentage of cases 815 16 Moreover, recent reports found that up to 20% of patients with MS with brain MRI findings highly suggestive for this disease16 17 can be consistently positive for antiphospholipid antibodies, thus suggesting a concomitant diagnosis of MS and APLAS.…”

mentioning

confidence: 99%

Brain involvement in systemic immune mediated diseases: magnetic resonance and magnetisation transfer imaging study

Rovaris¹

2000

Journal of Neurology, Neurosurgery &Amp; Psychiatry

113

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Objective-Magnetisation transfer imaging (MTI) provides information about brain damage with increased pathological specificity over conventional MRI and detects subtle abnormalities in the normal appearing brain tissue, which go undetected with conventional scanning. Brain MRI and MTI findings were compared in patients with multiple sclerosis (MS) and systemic immune mediated diseases (SIDs) aVecting the CNS to investigate their roles in understanding the nature of brain damage in these diseases. Methods-Brain dual echo, T1 weighted and MTI scans were obtained in patients aVected by systemic lupus erithematosus (SLE) with (NSLE, n=9) and without clinical CNS involvement (n=15), Behçet's disease (BD) (n=5), Wegener's granulomatosis (WG) (n=9), and antiphospholipid antibody syndrome (APLAS) (n=6).Ten patients with clinically definite MS and 15 healthy controls also underwent the same scanning protocol. Brain MRI and MT ratio (MTR) images of the same subject were coregistered and postprocessed to obtain MTR histograms of the whole brain and of the NABT. Results-Brain hyperintense lesions were found in all patients with MS and with NSLE and in 5/15 patients with SLE, 5/9 with WG, 1/5 with BD, and 3/6 with APLAS. The lesion burden in the brain was significantly higher in patients with MS compared with all the other disease groups. All MTR histogram parameters were significantly diVerent among patient subgroups. Patients with MS had significantly lower average MTR than all except patients with NSLE and significantly lower peak height and location than patients with SLE. patients with NSLE had significantly lower average MTR than patients with SLE. Conclusions-Microscopic brain tissue damage is relevant in patients with MS, but, apart from patients with NSLE, it seems to be absent in systemic immune mediated diseases, even in the presence of macroscopic MRI lesions or clinical evidence of CNS involvement.

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“…In contrast to Cuadrado's report, these patients frequently had antinuclear antibodies and low serum complement levels. Brain MRI studies could not distinguish one group from the other [71]. Tourbah and colleagues found no difference between patients with an aPL-associated MS-like illness and MS regarding age of onset, presenting symptoms and signs, neurological exam findings, or disease course.…”

Section: Transverse Myelopathy Optic Neuropathy and Multiple Sclerosismentioning

confidence: 94%

Differential Diagnosis of Central Nervous System Manifestations of the Antiphospholipid Antibody Syndrome

Brey

2000

Journal of Autoimmunity

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Anti-phospholipid antibodies in patients with multiple sclerosis and MS-like illnesses: MS or APS?

Cited by 83 publications

References 34 publications

Anticardiolipin antibodies in patients with multiple sclerosis do not represent a subgroup of patients according to clinical, familial, and biological characteristics

Anticardiolipin antibodies in patients with multiple sclerosis do not represent a subgroup of patients according to clinical, familial, and biological characteristics

Brain involvement in systemic immune mediated diseases: magnetic resonance and magnetisation transfer imaging study

Differential Diagnosis of Central Nervous System Manifestations of the Antiphospholipid Antibody Syndrome

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