Anti-Pituitary Antibodies in Children With Newly Diagnosed Celiac Disease: A Novel Finding Contributing to Linear-Growth Impairment

Delvecchio, Maurizio; Bellis, Annamaria De; Francavilla, Ruggiero; Rutigliano, Vincenzo; Predieri, Barbara; Indrio, Flavia; Venuto, D. De; Sinisi, Antonio Agostino; Bizzarro, Antonio; Bellastella, Antonio; Iughetti, Lorenzo; Cavallo, Luciano

doi:10.1038/ajg.2009.642

Cited by 38 publications

(29 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anti-pituitary antibodies are observed in conjunction with type-2 diabetes [159], [160] and GH1 is one of the autoantigens [161]. GH1 codes for human growth hormone, and growth impairment is observed in celiac disease in conjunction with anti-pituitary antibodies [162].…”

Section: Discussionmentioning

confidence: 99%

Coherent Somatic Mutation in Autoimmune Disease

Ross

2014

PLoS ONE

View full text Add to dashboard Cite

BackgroundMany aspects of autoimmune disease are not well understood, including the specificities of autoimmune targets, and patterns of co-morbidity and cross-heritability across diseases. Prior work has provided evidence that somatic mutation caused by gene conversion and deletion at segmentally duplicated loci is relevant to several diseases. Simple tandem repeat (STR) sequence is highly mutable, both somatically and in the germ-line, and somatic STR mutations are observed under inflammation.ResultsProtein-coding genes spanning STRs having markers of mutability, including germ-line variability, high total length, repeat count and/or repeat similarity, are evaluated in the context of autoimmunity. For the initiation of autoimmune disease, antigens whose autoantibodies are the first observed in a disease, termed primary autoantigens, are informative. Three primary autoantigens, thyroid peroxidase (TPO), phogrin (PTPRN2) and filaggrin (FLG), include STRs that are among the eleven longest STRs spanned by protein-coding genes. This association of primary autoantigens with long STR sequence is highly significant (). Long STRs occur within twenty genes that are associated with sixteen common autoimmune diseases and atherosclerosis. The repeat within the TTC34 gene is an outlier in terms of length and a link with systemic lupus erythematosus is proposed.ConclusionsThe results support the hypothesis that many autoimmune diseases are triggered by immune responses to proteins whose DNA sequence mutates somatically in a coherent, consistent fashion. Other autoimmune diseases may be caused by coherent somatic mutations in immune cells. The coherent somatic mutation hypothesis has the potential to be a comprehensive explanation for the initiation of many autoimmune diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Coherent Somatic Mutation in Autoimmune Disease

Ross

2014

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Antibodies to testis-specific antigen 10 were found in patients with autoimmune polyendocrine syndrome 1 [22]. APA titers were found in 42% of patients with newly diagnosed celiac disease [26]. APA and antihypothalamus antibodies (AHA) were assessed in patients with selective central deficiencies compared with controls [18 & ].…”

Section: Experimental Models and Autoimmunitymentioning

confidence: 99%

Update on the diagnosis and management of hypophysitis

Carmichael

2012

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

View full text Add to dashboard Cite

Hypophysitis is a rare disease with multiple subtypes. The description of hypophysitis related to cytotoxic T-lymphocyte antigen-4 antibody treatment is one of the first descriptions of hypophysitis triggered by medication. As the use of this novel treatment for cancer increases, so must our awareness of immune-related adverse effects and their treatment. Pituitary autoimmunity is a challenging field with multiple discoveries reported to help further our understanding of the disease and assist in diagnosis. Insufficient sensitivity and specificity of the currently reported methods prevents recommending measurement of antipituitary antibodies as standard of care in the diagnosis of hypophysitis. The treatment of hypophysitis remains controversial with recommendations ranging from hormonal replacement to newly described therapies such as azathioprine and radiation.

show abstract

“…The target organs include endocrine system [20–22], kidney [23, 24], skin [25], nervous system [26], and reproductive systems [27]. A number of hepatobiliary tract and pancreatic disorders have also been documented in patients with CD [28].…”

Section: Introductionmentioning

confidence: 99%

Hepatobiliary Disorders in Celiac Disease: An Update

Prasad

Debi

Sinha

et al. 2011

International Journal of Hepatology

View full text Add to dashboard Cite

This communication reviews recent literature and summarizes hepatobiliary abnormalities that may complicate the clinical course of celiac disease. A wide spectrum of hepatobiliary diseases has been described, including asymptomatic elevations of liver enzyme levels, nonspecific hepatitis, nonalcoholic fatty liver disease, and autoimmune and cholestatic liver disease. Moreover, in the majority of patients, liver enzyme levels will normalize on a gluten-free diet. In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma. Because many celiac patients do not have overt gastrointestinal symptoms, a high index of suspicion is required. Simple methods of detecting celiac disease such as serum antibody tests help in the early identification of the disease, thus preventing serious complications of the disorder. The IgG DGP antibody test and IgA tTG antibody test used in combination are an excellent screening test for suspected cases of celiac disease.

show abstract

Anti-Pituitary Antibodies in Children With Newly Diagnosed Celiac Disease: A Novel Finding Contributing to Linear-Growth Impairment

Abstract: In this paper we have shown a remarkable prevalence of positive APA in newly diagnosed CD patients. High APA titers are associated with height impairment, likely mediated by a reduction of IGF-1, thus suggesting that autoimmune pituitary process could induce a linear-growth impairment.

Cited by 38 publications

References 26 publications

Coherent Somatic Mutation in Autoimmune Disease

Coherent Somatic Mutation in Autoimmune Disease

Update on the diagnosis and management of hypophysitis

Hepatobiliary Disorders in Celiac Disease: An Update

Contact Info

Product

Resources

About