The purpose of this paper is to evaluate the stress concentration at the tip of a permeable interfacial crack near an eccentric elliptical hole in piezoelectric bi-materials under anti-plane shearing. Fracture analysis is performed by Green’s function method and the conformal mapping method, which are used to solve the boundary conditions problem. The mechanical model of the interfacial crack is constructed by interface-conjunction and crack-deviation techniques so that the crack problem is simplified as solving a series of the first kind of Fredholm’s integral equations, from which the dynamic stress intensity factors (DSIFs) at the inner and the outer crack-tips can be derived. The validity of the present method is verified by comparing with a crack emerging from the edge of a circular hole as a reference. Numerical cases reveal parametric dependence of DSIFs on the geometry of eccentric elliptical holes and interfacial cracks, the characteristics of the incident wave, the equivalent piezoelectric elastic modulus and piezoelectric parameters. The results illustrate that the eccentric distance has a great effect on the stress concentration at the crack tip, which may be harmful to the normal service of piezoelectric devices and materials. In addition, the method proposed in this paper can also deal with non-eccentric problems and has wider applicability.