Anti-proliferation and anti-migration effects of an aqueous extract of Cinnamomi ramulus on MH7A rheumatoid arthritis-derived fibroblast-like synoviocytes through induction of apoptosis, cell arrest and suppression of matrix metalloproteinase

Abstract

Pu (2020) Anti-proliferation and anti-migration effects of an aqueous extract of Cinnamomiramulus on MH7A rheumatoid arthritis-derived fibroblast-like synoviocytes through induction of apoptosis, cell arrest and suppression of matrix metalloproteinase,

Polygonum cuspidatum Extract Exerts Antihyperlipidemic Effects by Regulation of PI3K/AKT/FOXO3 Signaling Pathway

“…For qualitative analysis, a Thermo Scientific Q Exactive Orbitrap HRMS (Thermo Fisher Scientific, Massachusetts, USA) was connected to a Thermo Scientific Vanquish UPLC (Thermo Fisher Scientific, Massachusetts, USA). Chromatographic separation was achieved on a Thermo ScientificTM AccucoreTM C 18 (3 × 100 mm, 2.6 μ m) in a thermostatically controlled column compartment (30°C) [ 11 ].…”

“…According to reported literature data, 12 major compounds were finally identified and inferred based on their mass spectrometry behavior and fragment ion characteristics. Finally, by comparing these components with standard reference compounds, the 12 main compounds were identified as ellagic acid (1), polydatin (2), epicatechin gallate (3), resveratrol (4), cynaroside (5), glycitein (6), isokaempferide (7), luteolin (8), genistein (9), formonontin (10), emodin (11), and marmesin (12). The gene expression profile dataset "GSE1010" downloaded from the GEO database was analyzed and processed, and a volcano map of gene expression was obtained (Figure 4(a)).…”

Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis

“…Activated and abundant intracellular ROS can regulate cell cycle progression, proliferation efficiency, and naive-to-memory conversion ( 114 ). Anti-proliferative measures that induce cell cycle arrest may represent therapeutic approaches against RA ( 118 ). ROS-deficient RA T cells are unable to maintain their naive phenotype and bypass the G2/M cell cycle checkpoint to overproliferate (due to surplus reducing equivalents that do not adequately activate the redox-sensitive kinase ATM) ( 114 ).…”

Role of Plant-Derived Natural Compounds in Experimental Autoimmune Encephalomyelitis: A Review of the Treatment Potential and Development Strategy

“…Molecular docking is a drug design method based on the characteristics of receptors and the interaction mode between receptors and drug molecules. It is mainly a theoretical simulation method used to study the interaction between molecules (ligand and receptor), predict their binding ability and affinity, and verify the experimental results by assay ( Liu J. et al, 2020 ).…”

“…There have been many studies of the treatment of EAE by TCM monomers containing flavonoids, phenol, and glycosides, among others ( Ciumărnean et al, 2020 ; Ikram et al, 2020 ; Yang L. et al, 2020 ). Moreover, many researchers have studied the effect of chemical monomers by molecular docking, high-throughput screening, and network pharmacology ( Chen et al, 2020 ; Liu J. et al, 2020 ; Xu et al, 2020a ). Over the past 8 years, glycosides have been the most commonly studied compounds, and have been examined and developed with the intent of using them as a potential treatment for EAE ( Giacoppo et al, 2013 ; Yin et al, 2014 ; Haghmorad et al, 2017 ; Madhu et al, 2019 ; Yang L. et al, 2020 ).…”