Anti-proliferative activity of 6-<i>O</i>-acyl-<scp>d</scp>-allose against the human leukemia MOLT-4F cell line

Yanagita, Ryo C.; Kobashi, Katsuya; Ogawa, Chisa; Ashida, Yoshiki; Yamaashi, Haruka; Kawanami, Yasuhiro

doi:10.1080/09168451.2014.882747

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…The experiments carried out on both in vitro and in vivo cell models confirm that SFAE may inhibit the secretion of TNF-α and some proinflammatory cytokines such as IL-1B, IL-6 and IL-8 [17]. Moreover, their ability to inhibit in vitro excessive proliferation of bone marrow cells in the acute myelogenous leukemia model was also described [18]. It has also been shown that biological activity of SFAE may depend on the length of an aliphatic chain and their number in the whole ester molecule (mono-vs. di-vs. tri-/poly-esters).…”

Section: Introductionmentioning

confidence: 65%

In Search of Effective Anticancer Agents—Novel Sugar Esters Based on Polyhydroxyalkanoate Monomers

Snoch

Wnuk

Witko

et al. 2021

IJMS

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Cancer is one of the deadliest illness globally. Searching for new solutions in cancer treatments is essential because commonly used mixed, targeted and personalized therapies are sometimes not sufficient or are too expensive for common patients. Sugar fatty acid esters (SFAEs) are already well-known as promising candidates for an alternative medical tool. The manuscript brings the reader closer to methods of obtaining various SFAEs using combined biological, chemical and enzymatic methods. It presents how modification of SFAE’s hydrophobic chains can influence their cytotoxicity against human skin melanoma and prostate cancer cell lines. The compound’s cytotoxicity was determined by an MTT assay, which followed an assessment of SFAEs’ potential metastatic properties in concentrations below IC50 values. Despite relatively high IC50 values (63.3–1737.6 μM) of the newly synthesized SFAE, they can compete with other sugar esters already described in the literature. The chosen bioactives caused low polymerization of microtubules and the depolymerization of actin filaments in nontoxic levels, which suggest an apoptotic rather than metastatic process. Altogether, cancer cells showed no propensity for metastasis after treating them with SFAE. They confirmed that lactose-based compounds seem the most promising surfactants among tested sugar esters. This manuscript creates a benchmark for creation of novel anticancer agents based on 3-hydroxylated fatty acids of bacterial origin.

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Section: Introductionmentioning

confidence: 65%