2023
DOI: 10.1186/s12885-023-11547-1
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Anti-proliferative activity of RIHMS-Qi-23 against MCF-7 breast cancer cell line is through inhibition of cell proliferation and senescence but not inhibition of targeted kinases

Randa El-Gamal,
Sara Elfarrash,
Mohammad EL-Nablaway
et al.

Abstract: Background Breast cancer is the most common malignancy globally, and is considered a major cause of cancer-related death. Tremendous effort is exerted to identify an optimal anticancer drug with limited side effects. The quinoline derivative RIMHS-Qi-23 had a wide-spectrum antiproliferative activity against various types of cancer cells. Methods In the current study, the effect of RIMHS-Qi-23 was tested on MCF-7 breast cancer cell line to evaluate … Show more

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Cited by 3 publications
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“…Moving into 2021-2022, the research landscape expanded to include topics related to anticancer therapies, such as cancer therapy, and specific treatments, such as radiotherapy. The inclusion of terms like “MCF-7" suggests a focus on specific cell lines commonly used in breast cancer research [ 79 ]. Furthermore, there is evidence of a cross-disciplinary exploration of prostate cancer, indicating a broader investigation of cancer types beyond breast cancer alone [ 80 ].…”
Section: Discussionmentioning
confidence: 99%
“…Moving into 2021-2022, the research landscape expanded to include topics related to anticancer therapies, such as cancer therapy, and specific treatments, such as radiotherapy. The inclusion of terms like “MCF-7" suggests a focus on specific cell lines commonly used in breast cancer research [ 79 ]. Furthermore, there is evidence of a cross-disciplinary exploration of prostate cancer, indicating a broader investigation of cancer types beyond breast cancer alone [ 80 ].…”
Section: Discussionmentioning
confidence: 99%