Anti-proliferative activity of Thai Noni (Morinda citrifolia linn.) leaf extract

Thani, W.; Luanratana, O.; Siripong, Pongpun; Ruangwises, Nongluck

doi:10.1055/s-0028-1084124

Cited by 24 publications

(27 citation statements)

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“…Helianthus cell proliferation seem in agreement with previous data obtained with animal and human cell lines which confirmed the antiproliferative activity and the significant but non-selective cytotoxicity of Morinda extracts (Ashidi et al 2010;Thani et al 2010).…”

Section: Effects Of Noni Juice On H Tuberosus Explants 895supporting

confidence: 90%

Evaluation of noni (Morinda citrifoliaL.) juice antiproliferative activity using theHelianthus tuberosusclassicalin vitrogrowth model system

Ferri

Palma

Franceschetti

et al. 2012

Plant Biosystems - An International Journal Dealing with all As

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Morinda citrifolia L. (noni) is a tropical plant that has been used for centuries in traditional medicine for numerous purposes and, nowadays, is largely commercialised on the worldwide market as a dietary supplement. Long-term in vitro cultures of Helianthus tuberosus dormant parenchyma explants constitute a classical growth model that can be used to evaluate the proliferative or antiproliferative and/or cytotoxic effects of different mixtures of chemicals present in food or with putative pharmacological applications. Explants of dormant tubers were cultured in vitro with 2%, 10% and 20% (v/v) of noni fruit juice. After four weeks of culture, explant cell growth was reduced 40.5%, 72.5% and 73.9%, respectively, by 2%, 10% and 20% (v/v) of noni juice in comparison to untreated controls. Our results demonstrated that noni fruit juice possesses strong antiproliferative capacity, low cytotoxicity and moderate antioxidant activity.

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Section: Effects Of Noni Juice On H Tuberosus Explants 895supporting

confidence: 90%

Evaluation of noni (Morinda citrifoliaL.) juice antiproliferative activity using theHelianthus tuberosusclassicalin vitrogrowth model system

Ferri

Palma

Franceschetti

et al. 2012

Plant Biosystems - An International Journal Dealing with all As

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show abstract

“…In another study, Thani et al (2010) found the cytotoxic activity of noni leaves against the KB cell line while Lv et al (2011) found the anticancer potential in the root extracts. Gupta & Patel (2013) also demonstrated that combination of Noni and cisplatin were able to induced the anticancerous activity through the p53 and Bax proteins (pro-apoptotic) up regulating pathways and Bcl-2 (anti-apoptotic gene), survivin and Bcl-XL proteins down regulating mechanisms.…”

Section: Anticancer Activitymentioning

confidence: 99%

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Sunder¹,

Sujatha²,

Kundu³

2016

JEBAS

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KEYWORDS Morinda citrifolia Livestock Poultry Growth Production Immunomodulatory Properties ABSTRACTMorinda citrifolia L. is commonly known as Noni and has been found to have wide range of medicinal properties. It is usually found in the coastal region in many countries including Andaman and Nicobar Islands and belongs to the family Rubiaceae. This small evergreen tree is widely grown and well adapted to the tropics and can grow in fertile, acidic, alkaline and saline affected soils. It tolerates high soil salinity and brackish water stagnation. All the components of this plant have high demand in case of alternative medicines and herbal medicines. Due to its high demand and as a source of revenue generation the detail study on its nutritional benefits and therapeutic values are essential for its commercial exploitation. More than 200 nutraceutical compounds have been identified from the plant. Morinda citrifolia is reported to have broad spectrum biological activities such as antimicrobial, immunomodualtory, antioxidant wound healing etc. Apart from the in-vitro scientific validation of the activities and in-vivo trial in some lab animal model, the plant has been used for livestock and poultry health and production. A lot of reviews have been written on the different uses of Noni, however, scientific review on the use of this plant on the growth, production, immunomodulator and other pharmacological activities of M. citrifolia in livestock and poultry has not been compiled. Therefore this review discusses the compilation of the work done on the use of M. citrifolia in livestock and poultry.

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“…M. citrifolia leaves also have beneficial properties in the treatment of cancer. Thani, Vallisuta, Siripong, and Ruangwises () compared the anticancer effect of damnacanthal, rutin, and scopoletin components isolated from the crude extract of M. citrifolia leaves against several human cancer cell lines: KB (human epidermoid carcinoma), HeLa (human cervical carcinoma), MCF‐7 (human breast carcinoma), and HepG2 (human hepatocellular carcinoma). The assay was performed using the MTT colorimetric method.…”

Section: Phytotherapic Propertiesmentioning

confidence: 99%

Properties and Applications of Morinda citrifolia (Noni): A Review

Almeida

Oliveira

Hotza

2019

Comp Rev Food Sci Food Safe

114

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Morinda citrifolia commonly known as noni is a perennial plant originating in Southeast Asia, consumed over 2000 years. Due to its versatility of adaptation and use of the structures of the plant for different therapeutic purposes, noni attracted the attention of researchers from the pharmaceutical and food industry. Chemical and nutritional analyzes already performed in M. citrifolia reveal the existence of more than 200 phytochemical substances with bioactive properties such as acids, alcohols, phenols, saccharides, anthraquinones, carotenoids, esters, triterpenoids, flavonoids, glycosides, lactones, iridoids, ketones, lactones, lignans, nucleosides, triterpenides, sterols, and aromatic compounds. The high nutritional value of M. citrifolia may induce therapeutic effects, including antimicrobial and antioxidant properties. The main industrial products from this plant are beverages (juice drinks), powders (from dried fruits), oil (from seeds), and leaf powders. Biological and phytotherapeutic applications of M. citrifolia are promising, but more extensive studies are still required. Thus, this review aims to gather updated and comprehensive information on Morinda citrifolia, discussing its traditional use, biochemical, phytotherapics, and toxicological properties, as well as the recent advances in the processing and standardization of products derived from noni fruit.

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Anti-proliferative activity of Thai Noni (Morinda citrifolia linn.) leaf extract

Cited by 24 publications

References 0 publications

Evaluation of noni (Morinda citrifoliaL.) juice antiproliferative activity using theHelianthus tuberosusclassicalin vitrogrowth model system

Evaluation of noni (Morinda citrifoliaL.) juice antiproliferative activity using theHelianthus tuberosusclassicalin vitrogrowth model system

Effect of Morinda citrifolia in growth, production and immunomodulatory properties in livestock and poultry: a review

Properties and Applications of Morinda citrifolia (Noni): A Review

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