Anti-proliferative and anti-tumour effect of active components in donkey milk on A549 human lung cancer cells

Mao, Xueying; Gu, Jun; Sun, Yanan; Xu, Shi-Ping; Zhang, Xiaoying; Yang, Haiying; Ren, Fazheng

doi:10.1016/j.idairyj.2009.05.007

Cited by 105 publications

(73 citation statements)

References 22 publications

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“…In particular, studies have shown that lysozyme inhibits angiogenesis and has antitumor activity. Recent in vitro studies have noted an anti-proliferative and antitumor activity of donkey milk against the adenocarcinoma human alveolar basal epithelial cells (A549) through the stimulation of IL-2, IFN-g, IL-6, TNF-a, and IL-1b cytokines production, the modification of the cell cycle, and the induction of the apoptosis process [59]. Furthermore, it has been shown that equine lysozyme, which, as discussed before, is structurally homologous to α-lactalbumin, can form complexes with oleic acid called ELOA (equine lysozyme and oleic acid).…”

Section: Lysozymementioning

confidence: 99%

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

et al. 2017

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Donkey milk could be considered a good and safer alternative, compared to other types of milk, for infants affected by cow's milk protein allergy, when breastfeeding is not possible. Interestingly, donkey milk has low allergenicity, mainly due to the low total casein amount, and the content of some whey proteins that act as bioactive peptides. The amount of lysozyme, an antibacterial agent, is 1.0 g/L, similar to human milk. Lactoferrin content is 0.08 g/L, with this protein being involved in the regulation of iron homoeostasis, anti-microbial and anti-viral functions, and protection against cancer development. Lactoperoxidase, another protein with antibacterial function, is present in donkey milk, but in very low quantities (0.11 mg/L). β-lactoglobulin content in donkey milk is 3.75 g/L-this protein is able to bind and transport several hydrophobic molecules. Donkey milk's α-lactalbumin concentration is 1.8 g/L, very close to that of human milk. α-lactalbumin shows antiviral, antitumor, and anti-stress properties. Therefore, donkey milk can be considered as a set of nutraceuticals properties and a beverage suitable, not only for the growing infants, but for all ages, especially for convalescents and for the elderly.

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Section: Lysozymementioning

confidence: 99%

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

et al. 2017

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“…Research performed by Yvon et al (2018) in mice indicate that consumption of donkey milk has anti-inflammatory effect, leading to a reduction of microbiota imbalance in the studied mice [49]. Also, research conducted by Mao et al (2009) indicated the potential anti-tumor and anti-proliferative role of donkey milk active components [50].…”

Section: Literature Reviewmentioning

confidence: 92%

Analysis of Environmental Factors’ Impact on Donkeys’ Colostrum Quality

et al. 2018

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Abstract:Colostrum is a natural product, issued by both mammals and humans in the first week of lactation. Among different species, donkey colostrum is considered to have, in addition to a valuable composition in nutrients and immune factors, an outstanding similitude with human colostrum. In this context, and taking into account the scarcity of available data concerning the interaction between climate factors and colostrum quality, a trial was conducted aiming to identify the possible influence of environmental factors on donkey colostrum nutritional traits. A stock of 175 jennies from 7 farms located in Cluj and Sălaj Counties was analyzed over a 7-day postpartum period. During the experimental period, the daily temperature, humidity, and wind velocity data were collected. Strong positive correlations are reported between the studied colostrum nutritional traits (fat, protein and lactose). Testing the impact of some environmental parameters upon nutritional content of donkey colostrum indicated three factors that have an influence on the nutritional quality of donkey milk colostrum, labelled as: colostrum nutritional traits, environmental air traits and some colostrum nutritional traits, and climatic traits and some colostrum nutritional traits.

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“…Moreover, donkey milk whey proteins showed in vitro antiproliferative and anti-tumor activity (Mao et al, 2009). These properties have allowed its diffusion as fresh milk, milk powder and even in cosmetic products.…”

Section: Introductionmentioning

confidence: 99%

Donkey cheese made through pure camel chymosin

Iannella¹

2015

Afr. J. Food Sci.

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Cheese from donkey milk was never produced by traditional way. Research suggests that asinine milk by bovine chymosin form a very weak gel compared to the gel formed from bovine milk and with out curd formation. Encyclopedia of Dairy Sciences 2nd edition reported that no cheese is made from donkey milk, due to its particular caseinic composition that makes inefficient the traditional rennet coagulation. However, the author has recently discovered that pure camel chymosin is able to clot effectively the casein micelles of donkey milk. This investigation is aimed at experimental manufacturing of donkey cheese through pure camel chymosin. A total of five experiments were included in the present investigation. Before making cheese, the raw donkey milk samples were analyzed for their physico-chemical composition in order to better evaluate the successive properties of fresh donkey cheese. Cheese making using pure camel chymosin gave a yield of about 3.32% of fresh donkey cheese, however relative to the content of protein and fat of donkey milk. The fresh cheese after 12 h in molds, had a good content in total solids (35.65%). The low pH in cheese, after 30 min from the production (pH at 30 min 5.34), shows the efficient activity of starter cultures in asses' milk, and allows a good protection against pathogens agents. This application represents an informative step for further trials and could be useful for industrial scale cheese processing of donkey milk. More research is needed to study the mechanism of enzymatic coagulation in equid species and if donkey cheese can be addressed, such donkey milk, as alternative food for people suffering from food allergies.

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Anti-proliferative and anti-tumour effect of active components in donkey milk on A549 human lung cancer cells

Cited by 105 publications

References 22 publications

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

Role of Proteins and of Some Bioactive Peptides on the Nutritional Quality of Donkey Milk and Their Impact on Human Health

Analysis of Environmental Factors’ Impact on Donkeys’ Colostrum Quality

Donkey cheese made through pure camel chymosin

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